Ornidazole
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2019-09-19
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Clinical Pharmacology
Quinisol pills - an antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of ornidazole with intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of ornidazole interacts with the DNA of microorganism cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Indications
Trichomoniasis (urinary infections in women and men caused by Trichomonas vaginalis), amebiasis (all intestinal infections caused by Entamoeba histolica, including amebic dysentery, and all intestinal forms of amebiasis, especially amebic liver abscess), giardiasis. Prevention of anaerobic infections during operations on the colon and gynecological interventions.
Composition
One tablet contains: Active ingredient: Ornidazole - 500.0 mg. Auxiliary substances (core): microcrystalline cellulose 35.0 mg, starch 45.0 mg, croscarmellose sodium 10.0 mg, talc 6.0 mg, magnesium stearate 3.0 mg.
Excipients (shell): hypromellose 10.12 mg, macrogol 1.0125 mg. talc 8.0 mg, titanium dioscid 2.0 mg.
Ornidazole is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| pills | |||
| Ornidazole | Obolensky OP | Russia | pills |
| Ornidazole | Veropharm | Russia | pills |
| Gayro | Panacea Biotek | India | pills |
| Dazolic | Sun Pharmaceutical Industries Ltd | India | pills |
| Tiberal | Deva Holding A.Sh | Turkey | pills |
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Dosage and Administration
Ornidazole is prescribed orally after meals.
With trichomoniasis: inward 1.5 g once or 1 g in combination with intravaginal administration of 500 mg (vaginal pills) at night. You can carry out the treatment for 5 days, prescribing 1 tablet (500 mg) orally 2 times a day (morning and evening), also with the appointment of 1 vaginal tablet of 500 mg per night.
In amebic dysentery: adults and children with a body weight of more than 35 kg - 1.5 g once a day, with a body weight of more than 60 kg - 2 g / day. Children weighing 12-35 kg - 40 mg / kg / day. Course - 3 days.
For the treatment of other forms of amebiasis: adults and children over 12 years old - 0.5 g by mouth in the morning and evening for 5-10 days.
In Giardiasis: adults and children weighing more than 35 kg - 1.5 g 1 time per day; children weighing 12-35 kg - 40 mg / kg / day. Duration of treatment is 1-2 days.
Prevention of infections caused by anaerobic bacteria: 0.5-1 g before surgery, after surgery - 0.5 g 2 times a day for 3-5 days.
Adverse reactions
Drowsiness, headache, gastrointestinal dysfunction (including nausea), dizziness, tremor, muscle stiffness, poor coordination of movement, convulsions, fatigue, temporary loss of consciousness, sensory or mixed peripheral neuropathy, taste perversion, changes in liver function. "enzymes, allergic reactions.
Contraindications
Carefully: CNS diseases (including epilepsy, multiple sclerosis), liver diseases, alcoholism, pregnancy, lactation.
Drug interactions
Enhances the effect of coumarin anticoagulants, prolongs the muscle relaxant effect of vecuronium bromide. Unlike other imidazole derivatives (metronidazole), it is compatible with alcohol (does not inhibit acetaldehyde dehydrogenase).
Pregnancy and Lactation
Contraindicated in pregnancy (I term) and during lactation.
Special instructions
In the treatment of trichomoniasis should be the simultaneous treatment of both partners.
Overdosage
Symptoms: epileptiform convulsions, depression, peripheral neuritis.
Treatment: symptomatic.
- Brand name: Orgametril
- Active ingredient: Lynestrenol
- Dosage form: pills
- Manufacturer: Schering-Plough
- Country of Origin: USA
Studies and clinical trials of Ornidazole (Click to expand)
- Preparation of a multistructural film with CM-chitosan and PVA, and in vitro ornidazole release from the carrier
- Simultaneous determination of ofloxacin and ornidazole in pharmaceutical preparations by capillary zone electrophoresis
- Chiral separation of rac-Ornidazole and detection of the impurity of (R)-Ornidazole in (S)-Ornidazole injection and raw material
- Stereoselective pharmacokinetics of ornidazole after intravenous administration of individual enantiomers and the racemate
- Lipase-Catalyzed Resolutions of both Enantiomers of Ornidazole and Secnidazole
- Characterization and ornidazole release in vitro of a novel composite film prepared with chitosan/poly(vinyl alcohol)/alginate
- On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole
- Heterogeneity in the sensitivity of stocks and clones of Giardia to metronidazole and ornidazole
- The radiosensitizing effect of ornidazole in hypoxic mammalian tissue: An in vivo study
- Simple liquid chromatographic method for the determination of ornidazole and metronidazole in human serum
- Kinetics and reactivities of ruthenium(III)- and osmium(VIII)-catalyzed oxidation of ornidazole with chloramine-T in acid and alkaline media: A mechanistic approach
- Effect of surfactant on voltammetric behaviour of ornidazole
- In vivo and real time determination of ornidazole and tinidazole and pharmacokinetic study by capillary electrophoresis with microdialysis
- Heat capacity and thermodynamic properties of crystalline ornidazole (C7H10ClN3O3)
- Single oral dose of ornidazole in women with vaginal trichomoniasis: Fugere P, Verschelden G, Caron M Obstet Gynecol 62:502–505 Oct 1983
- Measurement of ornidazole by high-performance liquid chromatography
- Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode
- The ICH guidance in practice: stress degradation studies on ornidazole and development of a validated stability-indicating assay
- Lipase-catalyzed resolution of both enantiomers of Ornidazole and some analogues
- Detecting inflammation with 131I-labeled ornidazole
- Ornidazole-induced liver damage: report of three cases and review of the literature
- Effect of ornidazole and clarithromycin resistance on eradication of Helicobacter pylori in peptic ulcer disease
- Toxicity of ornidazole and its analogues to rat spermatozoa as reflected in motility parameters
- In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, α-chlorohydrin and 1-chloro-3-hydroxypropanone
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