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Panavir - purified extract of the shoots of the plant Solanum tuberosum; The main active ingredient is hexose glycoside, consisting of glucose, rhamnose, arabinose, mannose, xylose, galactose, and uronic acids.
Panavir is an antiviral and immunomodulatory agent. Increases the body’s non-specific resistance to various infections and contributes to the induction of interferon alpha and gamma leukocytes in the blood.
At therapeutic doses, the drug is well tolerated.
Tests have shown the absence of mutagenic, teratogenic, carcinogenic, allergenic and embryotoxic action. In preclinical studies on laboratory animals, negative effects on reproductive function and fetal development have not been established.
It has anti-inflammatory properties in experimental models of exudative edema, chronic proliferative inflammation and in the pseudo-allergic inflammatory test for concanavalin A.
An analgesic effect was shown on models of neurogenic pain and pain caused by inflammation and thermal irritation.
It has antipyretic effect.
On the model of parkinsonian syndrome caused by systemic administration of neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, neuroprotective properties are shown.
It has the ability to improve the function of the retina and optic nerve.
It has wound healing properties in terms of the model of gastric ulcer.
In the complex treatment of tick-borne encephalitis (reduction of viral load and removal of neurological symptoms, including anisoreflexia, reduced reflexes, painful exit points of the cranial nerves, nystagmus)
As part of complex therapy: herpes virus infections of various localization (including recurrent genital herpes, Herpes zoster and ophthalmic herpes).
Reduced immunity in combination with infectious diseases.
Cytomegalovirus infection in combination with habitual miscarriage.
In the complex therapy: human papillomavirus infection (anogenital warts).
Vaginal suppositories1 supp. active ingredient: Panavir (Solanum tuberosum shoots polysaccharides) 200 mcg
Excipients: polyethylene oxide 1500 (macrogol 1500) - 1.2599 g; polyethylene oxide 400 (macrogol 400) - 0.1399 g
Panavir is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Panavir||National Research Company||Russia||suppositories|
|Panavir||National Research Company||Russia||gel|
|Panavir||National Research Company||Russia||rectal suppositories|
|Panavir||National Research Company||Russia||ampoules|
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Dosage and Administration
Panavir in solution is used for intravenous administration of a therapeutic dose of 200 μg (the contents of one ampoule or vial) of the active substance twice with an interval of 48 or 24 hours. If necessary, a month later the course of treatment can be repeated.
Panavir solution to introduce a jet slowly.
For herpes - 5 ml IV per 48 hours, repeat the treatment after 1 month or at the time of exacerbation.
For papillomavirus infection - 5 ml i.v. in 48 hours, then 5 ml i.v. in 1 time in 7 days. Only 5 injections.
With tick-borne encephalitis - 5 ml i / v with an interval of 48 hours, only 3 injections.
The drug is well tolerated, possible complications may be associated with individual intolerance and hypersensitivity to the drug. Overdose may be a reversible violation of the functions of the kidneys and spleen. However, if any undesirable side effects appear, it is necessary to stop administering the drug and consult a doctor.
- individual intolerance;
- patients with severe pathology of the kidneys, spleen;
- pregnancy, lactation;
Panavir should not be used in patients who are allergic to the compound components of the drug: glucose, mannose, rhamnose, arabinose, xylose.
Panavir solution for intravenous administration: when used at the stage of preparation for pregnancy, it helps to reduce the frequency of reproductive losses in cytomegalovirus and herpes virus infections.
When the solution becomes cloudy, the drug is considered unsuitable for use.
Gel Panavir for external and local application: it is recommended to start treatment at the earliest possible stage of the disease, at the first signs (itching, tingling, redness, feeling of tension), in this case the development of the bubbly stage of the disease can be completely prevented.
Panavir® gel is not intended for use in ophthalmology. When applying the gel on the face should avoid contact with his eyes.
Panavir vaginal suppositories: simultaneous treatment of sexual partners is necessary to prevent urogenital reinfection. If there is no effect, the diagnosis should be confirmed.
Influence on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. Data on the possibility of a negative effect of the drug on the ability to drive vehicles and the implementation of potentially hazardous activities that require special attention and speed of psychomotor reactions are not available.
Cases of overdose are not registered. The results of preclinical studies indicate a low toxicity of the drug.
- Brand name: Panavir
- Active ingredient: Panavir
- Dosage form: Vaginal suppositories: cylindrical or cone-shaped, grayish-white, translucent.
- Manufacturer: National Research Company
- Country of Origin: Russia
- Study of Antiparkinsonic Activity of Panavir on a Model of Parkinson Syndrome Induced by Systemic Administration of MPTP to Outbred Rats and C57Bl/6 Mice
- Effects of Physicochemical Forms of Phenazepam and Panavir on Their Action at Ultra-Low Doses
- The physicochemical basis of the biological activity and pharmacological properties of the antiviral agent Panavir