Pancreatin
Biosynthesis
1626 Items
2019-09-19
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Clinical Pharmacology
Pancreatin- digestive enzyme agent. Compensates for the failure of the exocrine pancreatic function.
The enzymes amylase, lipase and protease, which are part of pancreatin, facilitate the digestion of carbohydrates, fats and proteins, which contributes to their more complete absorption in the small intestine.
Indications
Insufficiency of the exocrine function of the pancreas (chronic pancreatitis, cystic fibrosis, etc.).
Chronic inflammatory-dystrophic diseases of the stomach, intestines, liver, gallbladder; conditions after resection or irradiation of these organs, accompanied by impaired food digestion, flatulence, diarrhea (as part of combination therapy).
To improve the digestion of food in patients with normal function of the gastrointestinal tract in cases of errors in nutrition.
Preparation for X-ray and ultrasound examination of the abdominal cavity organs.
Composition
active substance: Pancreatin 250 mg
Pancreatin is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Pancreatin | Biosynthesis | Russia | pills |
| Creon | Abbott | USA | capsules |
| Pancreatin | Anzhero-Sudzhensky HFZ | Russia | pills |
| Micrazim® | AVVA RUS | Russia | capsules |
| Penzital | Shreya | India | pills |
| Mezim | Berlin-Chemie AG | Germany | pills |
| Pancreatin | Pharmstandard | Russia | pills |
| Pangrol | Berlin-Chemie/Menarini | Germany | capsules |
| Mezim forte | Berlin-Chemie/Menarini | Germany | pills |
| Hermital | Nordmark Artsnaymittel | Germany | capsules |
| Enzistal-P | Torrent | India | pills |
| Panzinorm | Krka dd Novo mesto AO | Slovenia | capsules |
| Panzinorm Forte | Krka dd Novo mesto AO | Slovenia | pills |
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Dosage and Administration
The dose (in terms of lipase) depends on the age and degree of insufficiency of the pancreas function. The average dose for adults - 150 000 IU / day. With complete insufficiency of the excretory function of the pancreas - 400 000 IU / day, which corresponds to the daily needs of an adult in lipase.
Maximum Daily Dose is 15 000 U / kg.
Children under the age of 1.5 years - 50 000 IU / day; over 1.5 years old - 100,000 U / day.
The duration of treatment can vary from several days (in case of a violation of the digestive process due to errors in the diet) to several months or even years (if necessary, constant replacement therapy).
Adverse reactions
From the digestive system: in some cases - diarrhea, constipation, a feeling of discomfort in the stomach, nausea. The causal relationship between the development of these reactions and the action of pancreatin has not been established, since These phenomena are symptoms of exocrine pancreatic insufficiency.
Allergic reactions: in some cases - skin manifestations.
Metabolism: with prolonged use in high doses, hyperuricuricuria may develop, in excessively high doses, an increase in plasma uric acid levels.
Other: with the use of high doses of pancreatin in children, perianal irritation may occur.
Contraindications
Hypersensitivity, acute pancreatitis, exacerbation of chronic pancreatitis.
Drug interactions
When used simultaneously with antacids containing calcium carbonate and / or magnesium hydroxide, it is possible to reduce the effectiveness of pancreatin.
With simultaneous use, it is theoretically possible to reduce the clinical efficacy of acarbose.
With the simultaneous use of iron preparations may decrease the absorption of iron.
Special instructions
The safety of using pancreatin during pregnancy is not well understood.
Application is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
When cystic fibrosis is not recommended the use of pancreatin in high doses due to the increased risk of stricture (fibrous colonopathy). The dose should be adequate to the amount of enzymes that is necessary for the absorption of fat, taking into account the quality and quantity of food consumed.
- Brand name: Pancreatine
- Active ingredient: Digestive enzymes
Studies and clinical trials of Pancreatin (Click to expand)
- Effect of retrogradation, pancreatin digestion and amylose/amylopectin ratio on the fermentation of starch by Clostridium butyricum (NCIMB 7423)
- Pancreatin.
- Pancreatin
- Studies on the Direct Compression of Pharmaceuticals, XXIII. Pancreatin, 1) Effect of Lubricants on Enzyme Activity after Storage.
- High-gradient magnetic affinity separation of trypsin from porcine pancreatin
- Comparative effects of enteric-coated pancreatin microsphere therapy after conventional and pylorus-preserving pancreatoduodenectomy
- Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial
- Reassemblable quasi-chip free-flow electrophoresis with simple heating dispersion for rapid micropreparation of trypsin in crude porcine pancreatin
- Quantitative comparison of casein and rapeseed proteolysis by pancreatin
- Enzymes in organic synthesis, 4. Investigation of the pancreatin-catalyzed acylation of cis-cyclopent-2-ene-1,4-diol with various trichloroethyl and vinyl Alkanoates
- The lipolytic activity of pancreatin U. S. P
- A critical investigation of the amylolytic activity of pancreatin and extract of malt
- A study of the tryptic activity of pancreatin U. S. P
- The carboxypeptidase activity of pancreatin U. S. P
- Pancreatin with high enzymatic activity
- The effect of paraformaldehyde, phenol and creosote on the digestive action of pepsin, pancreatin and diastase
- What is the quality of the pancreatin on the market?
- Critical remarks on the U. S. P. pancreatin assay
- The assay of pancreatin
- Pancreatin and its assay
- Chicken pancreatic enzymes for clinical use: 2. Preparation and storage stability of lipase-rich pancreatin
- Diabetes in pancreatectomized baboons: A model for pancreatin transplantation studies
- Release of peptides and amino acids from dietary proteins during sequential enzymatic digestion in vitro with pepsin, pancreatin + trypsin and erepsin
- An efficient process for the resolution of cis-4-O-protected-2-cyclopenten-1,4-diol using pancreatin lipase in [C8mim][PF6] as a reusable system
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