Paracetamol, Ascorbic Acid

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Paracetamol, Ascorbic Acid

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Adults and children over 12 years old (with a body weight of more than 50 kg) should be ingested 1 tablet 3-4 times a day with an interval between doses of 4-8 hours. Children from 6 to 12 years old - 1/2 tablet, the maximum daily dose - 2 pills.

The maximum duration of treatment for children is 3 days.

The maximum duration of treatment for adults is no more than 5 days when administered as an anesthetic and no more than 3 days as an antipyretic.

Adverse reactions

Paracetamol

On the part of the digestive system: rarely - nausea, very rarely - vomiting, diarrhea, pain in the epigastric region, jaundice, pancreatitis and increased activity of liver enzymes.

Allergic reactions: rarely - skin rash, pruritus, urticaria, angioedema.

From the hematopoietic system and the lymphatic system: very rarely - anemia, leukopenia.

Other: weakness.

Vitamin C

Allergic reactions: skin rash, skin flushing.

Contraindications

Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glycosuria.

- Severe kidney disease;

- severe liver disease;

- renal and / or liver failure;

- deficiency of glucose-6-phosphate dehydrogenase;

- erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;

- gastrointestinal bleeding;

- children's age up to 6 years;

- pregnancy;

- lactation period (breastfeeding).

With care: erosive and ulcerative lesions of the gastrointestinal tract (in history), congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes); blood diseases (thrombocytopenia, leukopenia, agranulocytosis), sideroblastic anemia, thalassemia; hemochromatosis, hyperoxaluria, urolithiasis; bronchial asthma; alcoholism.

Drug interactions

While taking other medicines with Paracetamol EXTRATAB, you should consult with your doctor.

Paracetamol reduces the effectiveness of uricosuric drugs.

With prolonged and regular use, paracetamol potentiates the action of warfarin and other coumarin derivatives and increases the risk of bleeding.

Simultaneous use of Kolestiramine reduces the absorption of paracetamol (and weakens the effects of paracetamol).

Metoclopramide and domperidone increase the absorption of paracetamol.

The simultaneous use of paracetamol and NSAIDs (including metamizole sodium, acetylsalicylic acid, ibuprofen) increases the risk of "analgesic" nephropathy and renal papillary necrosis, end-stage renal failure.

The simultaneous use of paracetamol and chloramphenicol may be accompanied by an increase in T_1/2 chloramphenicol up to 5 times.

Inductors of liver microsomal enzymes (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with small overdose.

Salicylamide increases T_1/2 paracetamol, which leads to the accumulation of paracetamol and, accordingly, increased formation of its toxic metabolites.

The simultaneous use of paracetamol and ethanol can enhance the hepatotoxicity of paracetamol, as well as contribute to the development of acute pancreatitis.

Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity.

Do not use simultaneously other drugs containing paracetamol, as well as other non-narcotic analgesics. The simultaneous use of other medicines must be agreed with the doctor.

Ascorbic acid increases the concentration in the blood of benzylpenicillin and tetracyclines; at a dose of 1 g / day increases the bioavailability of ethinyl estradiol (includingincluded in oral contraceptives); improves the absorption of iron preparations in the intestine (converts ferric iron to ferrous iron); may increase the excretion of iron while using with deferoxamine; reduces the effectiveness of heparin and indirect anticoagulants.

Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drinks reduce the absorption and absorption of ascorbic acid. With simultaneous use with acetylsalicylic acid increases the excretion of urine ascorbic acid and decreases the excretion of acetylsalicylic acid.

Acetylsalicylic acid reduces the absorption of ascorbic acid by approximately 30%.

Ascorbic acid increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows the kidneys excretion of acids, increases the excretion of drugs having an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.

Drugs quinoline series, calcium chloride, salicylates, corticosteroids with long-term use deplete ascorbic acid reserves.

With simultaneous use of ascorbic acid reduces the chronotropic effect of isoprenaline.

With prolonged use or use in high doses, ascorbic acid may interfere with the interaction of disulfiram and ethanol; in high doses increases the excretion of meksiletin kidneys.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

Ascorbic acid reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Pregnancy and Lactation

Special instructions

Overdosage