Buy Pentalgin pills 24 pcs
  • Buy Pentalgin pills 24 pcs


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Clinical Pharmacology

The combined drug has analgesic, antipyretic and anti-inflammatory effect.

Drotaverine - has myotropic antispasmodic effect due to inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, urinary and vascular systems.

Pheniramine is a blocker of H1-histamine receptors. It has an antispasmodic and mild sedative effect, reduces the phenomenon of exudation, and also enhances the analgesic effect of paracetamol and naproxen.

Paracetamol is a non-narcotic analgesic that has antipyretic and analgesic effects due to the blockade of cyclooxygenase in the central nervous system and the effect on pain and thermoregulation centers.

Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of cyclooxygenase, which regulates the synthesis of prostaglandins.

Caffeine - causes dilation of the blood vessels of skeletal muscles, heart, kidneys; increases mental and physical performance, helps eliminate fatigue and drowsiness; increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the brain vessels.


  • mild and moderate pain syndrome of various genesis (including pain in the joints, muscles, sciatica, algomenorrhea, neuralgia, headache, migraine, toothache);
  • feverish conditions, catarrhal and other diseases accompanied by pain and inflammation.


1 tablet contains: paracetamol 325 mg, naproxen 100 mg, caffeine 50 mg, drotaverine hydrochloride - 40 mg, pheniramine maleate - 10 mg;
Excipients:microcrystalline cellulose, potato starch, croscarmellose sodium, giproloza (hydroxypropylcellulose (Klucel EF)), citric acid monohydrate, butylhydroxytoluene (E 321), magnesium stearate, talc, quinoline yellow (E 104), indigocarmine (E 104), indigocarmine yellow (E 104), indigo carmine, talc, talc, talc;

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Dosage and Administration

Pentalgin take orally 1 tablet 1-3 times a day.

The maximum daily dose - 4 pills.

The duration of treatment is not more than 3 days as an antipyretic and no more than 5 days as an anesthetic.

Continuation of drug treatment is possible only after consulting a doctor.

Adverse reactions

Allergic reactions:skin rash, pruritus, urticaria, angioedema;

From the side of blood-forming organs:thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;

From the nervous system: excitement, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, decreased concentration of attention;

Since the cardiovascular system:heartbeat, arrhythmias, high blood pressure;

From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, abnormal liver function;

From the urinary system: impaired renal function;

From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma;

Other: dermatitis, tachypnea (increased breathing).


Carefullythe drug should be used in case of mild to moderate arterial hypertension, gastric ulcer and / or duodenal ulcer in remission, as well as in elderly patients.

Drug interactions

With the simultaneous use of funds that have a depressant effect on the central nervous system (including sedatives and tranquilizers), it is likely that the intensity of the sedative effect and the inhibitory effect on the respiratory center will increase. Enhances the effect of ethanol on the psychomotor response.

Metamizole sodium reduces the concentration of cyclosporine. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from the connection with the protein, increases their activity.

Tricyclic antidepressants, oral contraceptives, allopurinol violate the metabolism of metamizol in the liver and increase its toxicity.

The simultaneous use of the drug with other non-narcotic analgesics can lead to increased toxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizol.

Pregnancy and Lactation

The drug is contraindicated during pregnancy and lactation (breastfeeding).

Special instructions

Concurrent use should be avoided. Pentalgin with other agents containing paracetamol and / or other nonsteroidal anti-inflammatory drugs, as well as with agents to alleviate the symptoms of cold, flu and nasal congestion.

When using the drug for more than 5-7 days, you should monitor the indicators of peripheral blood and liver functional status.

Paracetamol distorts the results of laboratory studies of glucose and uric acid in plasma.

If necessary, determine the 17-ketosteroids drug should be canceled 48 hours before the study. Note that naproxen increases bleeding time.

The effect of caffeine on the central nervous system depends on the type of the nervous system and can manifest itself as excitation and inhibition of higher nervous activity.

During the period of treatment should not consume alcoholic beverages.

In some cases, the concentration of attention and speed of psychomotor reactions may decrease, therefore, during the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require high concentration of attention and psychomotor speed.


Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disturbances, delirium, weakness, respiratory depression.

Treatment: induction of vomiting, gastric lavage through a tube, administration of adsorbents (Activated charcoal), symptomatic therapy aimed at maintaining vital functions.

  • Brand name: Pentalgin
  • Active ingredient: Paracetamol, Naproxen, Caffeine, Drotaverine, Pheniramine
  • Dosage form: Coated pills
  • Manufacturer: Pharmstandard
  • Country of Origin: Russia

Studies and clinical trials of Pentalgin (Click to expand)

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