Pharmatex® [Benzalkonium chloride]
Nizhpharm
826 Items
2019-09-19
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Clinical Pharmacology
Contraceptive local (spermicidal) agent, also has an antiseptic, antifungal, antiprotozoal effect; inactivates the Herpes simplex virus. It shows bactericidal activity against staphylococci, streptococci, gram-negative bacteria (intestinal and pseudomonas bacilli, gonococci, Proteus, Klebsiella and others), anaerobic bacteria, fungi and molds. It acts on bacteria strains resistant to antibiotics and other chemotherapeutic drugs; suppresses plasma coagulase and staphylococcal hyaluronidase. The spermicidal effect is due to the ability to damage the sperm membranes (at the beginning of the flagella, then the head), which makes it impossible to fertilize the damaged spermatozoon. The effect develops 5 minutes after the introduction of the vaginal suppository. It is active in the prevention of sexually transmitted diseases (gonorrhea, chlamydia, trichomoniasis). It does not affect the normal microflora of the vagina (including the Doderlein wand) and the hormonal cycle.
Indications
Local contraception for women of reproductive age (the presence of contraindications to oral contraceptives or intrauterine contraception; the postpartum period, the lactation period; the period after the termination of pregnancy; the premenopausal period; the need for episodic protection from pregnancy; skipping or late intake of constantly used oral contraceptives).
Composition
Active ingredient: myristinium chloride (benzalkonium chloride C14) - 18.9 mg.
Benzalkonium chloride is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Benatex | Nizhpharm | Russia | suppositories |
| Pharmatex® | Innotech International | France | vaginal capsules |
| Pharmatex® | Innotech International | France | cream |
| Pharmatex® | Innotech International | France | suppositories |
| Pharmatex® | Innotech International | France | pills |
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Dosage and Administration
Pre-freeing the suppository from the contour packaging, it is inserted deep into the vagina in a supine position 5 minutes before sexual intercourse; duration of action - 4 hours. Single dose: 1 suppository is designed for 1 sexual intercourse. Be sure to introduce a new vaginal suppository in the case of repeated sexual acts. Frequency of use is limited by the individual tolerance of the active substance and the frequency of sexual acts.
Adverse reactions
Allergic reactions, contact dermatitis, itching and burning in the vagina and / or the penis of the partner, painful urination.
Contraindications
Hypersensitivity to the components of the drug, colpitis, ulceration and irritation of the mucous membrane of the vagina and uterus.
Special instructions
To increase the effectiveness, it is necessary to carefully observe the method of use of the drug. May be used in conjunction with the vaginal diaphragm or intrauterine contraception. After intercourse, intravaginal use of hygienic products is not recommended (douching with soapy water, since soap destroys the active substance of the drug) in order to avoid loss of the contraceptive effect; possible external toilet genitals. Influence on ability to drive vehicles and work with mechanisms There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.
- Brand name: Benatex
- Active ingredient: Benzalkonium chloride
- Dosage form: Vaginal suppositories
- Manufacturer: Nizhpharm
- Country of Origin: Russia
Studies and clinical trials of Benzalkonium chloride (Click to expand)
- Percutaneous absorption and skin erythema: Quantification of capsaicin and its synthetic derivatives from gels incorporated with benzalkonium chloride by using non-invasive bioengineering methods
- Determination of benzalkonium chloride in drug formulations by capillary electrophoresis (CE)
- Salting-out solvent extraction for the off-line preconcentration of benzalkonium chloride in capillary electrophoresis
- Use of Chemotaxonomy To Study the Influence of Benzalkonium Chloride on Bacterial Populations in Biodegradation Testing
- Fate of Benzalkonium Chloride in a Sewage Sludge Low Temperature Conversion Process Investigated by LC-LC/ESI-MS/MS
- Regeneration of myenteric plexus in the mouse colon after experimental denervation with benzalkonium chloride
- Analysis of benzalkonium chloride by capillary electrophoresis-tandem mass spectrometry
- Embryotoxicity of benzalkonium chloride in vaginally treated rats
- Antithrombogenic effect of a graphite, benzalkonium chloride, and heparin coating on a flexible polyvinyl chloride plastic implant in the rabbit
- Efflux mediated adaptive and cross resistance to ciprofloxacin and benzalkonium chloride in Pseudomonas aeruginosa of dairy origin
- Adaptive response of single and binary Pseudomonas aeruginosa and Escherichia coli biofilms to benzalkonium chloride
- Development of Calcitonin Salmon Nasal Spray: Similarity of peptide formulated in chlorobutanol compared to benzalkonium chloride as preservative
- Modified Hofmann degradation for the analysis of n-alkylbenzyldimethylammonium chlorides by gas chromatography II. Benzalkonium chloride
- Urea as a tableting agent for benzalkonium chloride
- Sorption of benzalkonium chloride by an insoluble polyamide
- Coacervate formation by sodium salicylate with benzalkonium chloride
- Coacervate formation by inorganic salts with benzalkonium chloride
- Effect of hydroxy group on coacervate formation by sodium hydroxybenzoates with benzalkonium chloride
- Enhancement of benzalkonium chloride and chlorhexidine acetate activity against pseudomonas aeruginosa by aromatic alcohols
- Reduced binding of sulfaethidole to bovine serum albumin in presence of benzalkonium chloride
- Electron microscope study of effect of benzalkonium chloride and edetate disodium on cell envelope of Pseudomonas aeruginosa
- Differences in antibacterial activity of benzalkonium chloride
- Determination of benzalkonium chloride by reversed-phase high-pressure liquid chromatography
- Influence of benzalkonium chloride on the dissolution rate behavior of several solid-phase preparations of cholesterol in bile acid solutions
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