Buy Mezaton ampoules 1%, 1 ml, 10 pcs
  • Buy Mezaton ampoules 1%, 1 ml, 10 pcs

Phenylephrine

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2019-09-19
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Clinical Pharmacology

MESATON - alpha-adrenomimetic, vasoconstrictor, vasoconstrictor. Stimulates postsynaptic alpha adrenoreceptors.
Biotransformation in the liver and digestive tract (without catechol-O-methyltransferase). Excreted by the kidneys as metabolites. The action begins immediately after administration and lasts for 20 (after intravenous administration) - 50 minutes (with a s / c injection) - 1-2 hours (after a / m injection).
The heart rate decreases, the shock output increases, the SBP and DBP increase, the pulse reflexively decreases. OPSS is growing. Stimulates the brain and spinal cord. Reduces blood flow - renal, dermal, in the abdominal organs and limbs, increases - the coronary. It constricts the pulmonary vessels and increases the pressure in the pulmonary artery. As a vasoconstrictor, it has an anti-congestive effect: it reduces swelling and hyperemia of the nasal mucosa, the severity of exudative manifestations, restores free breathing; lowers pressure in the paranasal cavities and in the middle ear. It causes dilated pupils, normalizes intraocular pressure in open-angle glaucoma.

Indications

Subdural and inhalation anesthesia (to maintain adequate levels of blood pressure and prolongation of subdural anesthesia), local anesthesia (as a vasoconstrictor), acute circulatory failure, anaphylaxis, neurogenic shock, hypotension, including orthostatic, paroxysmal supraventricular tachycardia, reperfusion arrhythmias (Berzold-Jarish reflex), priapism, secretory prerenal anuria, iritis, iridocyclitis.

Composition

Phenylephrine 10 mg / ml.

Phenylephrine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
ampoules
Phenylephrine-Optic eye drops
solution
Nasol Bayer Pharma AG Germany spray
Nasol Bayer Pharma AG Germany drops
Irifrin Sentiss Pharma India eye drops
Relief Bayer Pharma AG Germany ointment
Relief Bayer Pharma AG Germany rectal suppositories

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Phenylephrine

Dosage and Administration

Nasol Baby is used intranasally, the bottle is slightly squeezed, holding it upside down. For children under 1 year old: single dose - 1 drop no more often than every 6 hours. For children aged 1 to 6 years old: single dose - 1- 2 drops. For children over the age of 6 years and adults: a single dose - 3-4 drops. After use, wipe the pipette dry on the bottle. The duration of treatment is no more than 3 days.

Adverse reactions

Local reactions: sometimes burning, tingling or tingling in the nose. Systemic effects: headache, dizziness, palpitations, arrhythmia, increased blood pressure, sweating, pallor, tremor, sleep disturbance.

Contraindications

increased individual sensitivity to the ingredients Nasol Beby; diseases of the cardiovascular system (including coronarosclerosis, angina); hypertensive crisis; thyrotoxicosis; diabetes mellitus. With caution: children up to 6 years old; pregnancy; lactation.

Special instructions

Children under 1 year old Nasol Baby should be used strictly as prescribed by a doctor and no more often than every 6 hours. In children, systemic absorption of phenylephrine and the associated risk of side effects is higher than in adults.

  • Brand name: Mezaton
  • Active ingredient: Phenylephrine
  • Dosage form: Injection.
  • Manufacturer: Cosmo

Studies and clinical trials of Phenylephrine (Click to expand)

  1. Enantiomer separations of phenylephrine and synephrine by capillary electrochromatography on bare silica stationary phase using hydroxypropyl-β-cyclodextrin as a mobile phase additive
  2. Novel site-specific chemical delivery system as a potential mydriatic agent: Formation of phenylephrine in the iris-ciliary body from phenylephrone chemical delivery systems
  3. Improving the ocular absorption of phenylephrine
  4. Ocular absorption and disposition of phenylephrine and phenylephrine oxazolidine
  5. Cellular localization of integrin isoforms in phenylephrine-induced hypertrophic cardiac myocytes
  6. The Transcriptional Coactivator p300 Plays a Critical Role in the Hypertrophic and Protective Pathways Induced by Phenylephrine in Cardiac Cells but Is Specific to the Hypertrophic Effect of Urocortin
  7. ChemInform Abstract: A Practical Synthesis of (R)-(-)-Phenylephrine Hydrochloride.
  8. Fos expression by glutamatergic neurons of the solitary tract nucleus after phenylephrine-induced hypertension in rats
  9. Age- and pathology-dependent alterations in the efficacy of phenylephrine- and 5-hydroxytryptamine-induced contractions in isolated rat aorta
  10. Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis
  11. Alteration of hepatic tissue spaces by platelet-activating factor and phenylephrine
  12. Intracellular calcium–mediated activation of hepatic Na+/H+ exchange by arginine vasopressin and phenylephrine
  13. Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid
  14. Enantiomeric separation of amphetamine and phenylephrine by capillary zone electrophoresis with hydroxypropyl-β-cyclodextrin as chiral additive
  15. Synthesis of tritium labeled phenylephrine
  16. Synthesis of [11C](−)-α,α-dideutero-phenylephrine for in vivo kinetic isotope studies
  17. Colorimetric determination of phenylephrine using 4-aminoantipyrine
  18. Ion exchange separation and colorimetric determination of phenylephrine in pharmaceutical products
  19. New route to phenylephrine
  20. Colorimetric determination of phenylephrine using 4-aminoantipyrine
  21. Degradation of phenylephrine hydrochloride in tablet formulations containing aspirin
  22. Gastric ulcers induced by phenylephrine in certain pharmaceutical compositions

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