Phthalylsulfathiazole
Irbit HFZ
1294 Items
2019-09-19
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Clinical Pharmacology
Ftalazol is an antimicrobial agent from the group of sulfonamides. It has a wide spectrum of action, including pathogens of intestinal infections. Acts predominantly in the intestinal lumen. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, violates the formation of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.
Indications
Dysentery, colitis, gastroenteritis, bowel surgery (for the prevention of purulent complications).
Composition
1 tablet contains 0.5 g of phthalylsulfathiazole.
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Dosage and Administration
Inside, in acute dysentery for adults in 1-2 days - 1 g 6 times a day, in 3-4 days - 1 g 4 times a day, in 5-6 days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, the second course of treatment is carried out: 1-2 days - 1 g 5 times a day (in the afternoon - every 4 hours, at night - in 8 hours), 3-4 days - 1 g 4 times a day (do not give at night), 5 day - 1 g 3 times a day. The total dose in the second cycle - 21 g, with a light current - 18 g.
Higher doses for adults: single - 2 g, daily - 7 g.
Children up to 3 years old - at 0.2 g / kg in 3 doses for 7 days, over 3 years old - at 0.4-0.75 g 4 times a day.
For other infections, adults in the first 2-3 days are prescribed 1-2 g every 4-6 hours, in the next 2-3 days - half the dose; children - 0.1 g / kg / day in equal doses after 4 hours with a night break, on the following days - 0.2-0.5 g every 6-8 hours.
Ftalazol treatment, if necessary, combined with the appointment of antibiotics. It is advisable to simultaneously appoint well absorbed sulfonate with Ftalazol
Adverse reactions
Allergic reactions (rash, fever), vitamin B deficiency (due to inhibition of intestinal microflora), agranulocytosis, aplastic anemia.
Contraindications
Increased individual sensitivity to sulfa drugs, diseases of the blood system, diffuse toxic goiter, kidney disease, acute hepatitis, intestinal obstruction
Drug interactions
When using Ftalazol in conjunction with other drugs, the following interactions may occur.
PAS and barbiturates: increased activity of sulfonamides.
Thioacetazone, chloramphenicol: increases the possibility of agranulocytosis.
Nitrofurans: increases the risk of anemia and methemoglobinemia.
Indirect anticoagulants: enhanced anticoagulant action.
Oxacillin: antibiotic activity is reduced.
The combined use of Ftalazol with acids and acid-reactive drugs, hexamethylenetetramine, adrenaline solution is impractical, because they are chemically incompatible.
With the combined use of Ftalazol with preparations containing PABA esters (novocaine, anestezin, dikain), the antibacterial activity of sulfanilamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well absorbed sulfonamides.
- Brand name: Phthalazole
- Active ingredient: Phthalylsulfathiazole
- Dosage form: Pills.
- Manufacturer: Irbit HFZ
- Country of Origin: Russia
Studies and clinical trials of Phthalylsulfathiazole (Click to expand)
- Phthalylsulfathiazole-‘sulfathalidine’: A clinical evaluation in 122 patients with proctologic and related conditions
- Phthalylsulfathiazole (Sulfathalidine) in thetreatment of enterobiasis (Pinworm infection)
- A new quantitative approach to the study of anthelminthic drugs, with an evaluation of piperazine hexahydrate, phthalylsulfathiazole, and RO 2-5655/3 in the treatment of Enterobius infection
- [ACS Symposium Series] Macro- and Microemulsions Volume 272 (Theory and Applications) || Kinetics of Xylene Coagulation in Water Emulsion Stabilized by Phthalylsulfathiazole
- Effect of Phthalylsulfathiazole on Growth and Reproduction of Rats Fed a Soybean Protein Ration.
- EVALUATION OF NEOMYCIN-PHTHALYLSULFATHIAZOLE IN PREPARATION OF THE LARGE BOWEL FOR SURGERY
- INTRAPERITONEAL ADMINISTRATION OF SUCCINYLSULFATHIAZOLE AND PHTHALYLSULFATHIAZOLE
- PHTHALYLSULFATHIAZOLE ("SULFATHALIDINE")
- UV–visible light-activated Au@ pre-sulphated, monodisperse TiO2 aggregates for treatment of congo red and phthalylsulfathiazole
- The Use of Phthalylsulfathiazole (Sulfathalidine) in Colonic Surgery
- Treatment of urinary tract infections with sulfathalidine (phthalylsulfathiazole)
- In Vitro Action of Sulfamerazine, Phthalylsulfadiazine, Phthalylsulfamerazine and Phthalylsulfathiazole on Enteric Pathogens
- The Therapeutic Value of Two New Sulfonamide Compounds, Succinylsulfathiazole and Phthalylsulfathiazole, in Experimental Trichinosis
- Studies on Decomposition and Stabilization of Drugs in Solution. XVIII. The Hydrolysis of Phthalylsulfathiazole
- The Treatment of E. Coli Urinary Infections with Sulfathalidine (Phthalylsulfathiazole) 1 1Read at annual meeting, Mid-Atlantic Section, American Urological Association, Washington, D. C., March 21, 1947.
- Calcium Oxalate Excretion and Hematuria in Vitamin B6-Deficient Rats Fed Phthalylsulfathiazole
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