

Ftalazol is an antimicrobial agent from the group of sulfonamides. It has a wide spectrum of action, including pathogens of intestinal infections. Acts predominantly in the intestinal lumen. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, violates the formation of tetrahydrofolic acid necessary for the synthesis of purines and pyrimidines.
Dysentery, colitis, gastroenteritis, bowel surgery (for the prevention of purulent complications).
1 tablet contains 0.5 g of phthalylsulfathiazole.
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Inside, in acute dysentery for adults in 1-2 days - 1 g 6 times a day, in 3-4 days - 1 g 4 times a day, in 5-6 days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, the second course of treatment is carried out: 1-2 days - 1 g 5 times a day (in the afternoon - every 4 hours, at night - in 8 hours), 3-4 days - 1 g 4 times a day (do not give at night), 5 day - 1 g 3 times a day. The total dose in the second cycle - 21 g, with a light current - 18 g.
Higher doses for adults: single - 2 g, daily - 7 g.
Children up to 3 years old - at 0.2 g / kg in 3 doses for 7 days, over 3 years old - at 0.4-0.75 g 4 times a day.
For other infections, adults in the first 2-3 days are prescribed 1-2 g every 4-6 hours, in the next 2-3 days - half the dose; children - 0.1 g / kg / day in equal doses after 4 hours with a night break, on the following days - 0.2-0.5 g every 6-8 hours.
Ftalazol treatment, if necessary, combined with the appointment of antibiotics. It is advisable to simultaneously appoint well absorbed sulfonate with Ftalazol
Allergic reactions (rash, fever), vitamin B deficiency (due to inhibition of intestinal microflora), agranulocytosis, aplastic anemia.
Increased individual sensitivity to sulfa drugs, diseases of the blood system, diffuse toxic goiter, kidney disease, acute hepatitis, intestinal obstruction
When using Ftalazol in conjunction with other drugs, the following interactions may occur.
PAS and barbiturates: increased activity of sulfonamides.
Thioacetazone, chloramphenicol: increases the possibility of agranulocytosis.
Nitrofurans: increases the risk of anemia and methemoglobinemia.
Indirect anticoagulants: enhanced anticoagulant action.
Oxacillin: antibiotic activity is reduced.
The combined use of Ftalazol with acids and acid-reactive drugs, hexamethylenetetramine, adrenaline solution is impractical, because they are chemically incompatible.
With the combined use of Ftalazol with preparations containing PABA esters (novocaine, anestezin, dikain), the antibacterial activity of sulfanilamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well absorbed sulfonamides.
Studies and clinical trials of Phthalylsulfathiazole (Click to expand)