Pipemidic acid
Sandoz
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Clinical Pharmacology
Palin - antibacterial drug from the group of quinolones. Bactericidal effect.
A drugactive against gram-negative bacteria: Escherichia coli, Klebsiella pneumoniae, Enterobacter spp., Proteus mirabilis, Proteus vulgaris, Neisseria spp., Pseudomonas aeruginosa;Gram-positive bacteria: Staphylococcus aureus.
A drugnot active against anaerobic microorganisms.
Indications
Acute and chronic infectious and inflammatory diseases of the urinary tract caused by susceptible microorganisms:
- pyelonephritis;
- urethritis;
- cystitis;
- prostatitis.
Prevention of infections with instrumental interventions in urological and gynecological practice.
Composition
1 capsule contains 200 mg pipemidovoy acid (in the form of the trihydrate);
Excipients: magnesium stearate, colloidal silicon dioxide, corn starch
Pipemidic acid is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Palin | Sandoz | Switzerland | capsules |
| capsules |
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Dosage and Administration
When ingestion - 400 mg 2 times / day for 10 days. In some cases, a single dose may be increased to 600 mg.
With frequent acute urinary tract infections in women, intravaginally is administered simultaneously with oral treatment.
Adverse reactions
On the part of the digestive system: nausea, vomiting, diarrhea.
Allergic reactions: skin rash, itching.
Contraindications
Severe renal dysfunction (CK <10 ml="" min="" pronounced="" hepatic="" dysfunction="" i="" and="" iii="" trimesters="" of="" pregnancy="" childhood="" hypersensitivity="" to="" pipemidic="" acid="" p="">
Drug interactions
At simultaneous use with the preparations alkalizing urine, activity of Pipemidic acid amplifies.
Pregnancy and Lactation
Pipemidic acid is contraindicated for use in the I and III trimesters of pregnancy. Use in the second trimester of pregnancy and lactation (breastfeeding) should be carried out with caution, only in cases where the expected therapeutic effect for the mother outweighs the potential risk of side effects in the fetus or child.
Special instructions
In the course of treatment, ultraviolet irradiation should be avoided due to the high risk of photosensitization; increase the amount of fluid consumed (under the control of diuresis).
- Active ingredient: Pipemidic acid
Studies and clinical trials of Pipemidic acid (Click to expand)
- A new method of quantification of pipemidic acid by capillary zone electrophoresis with end-column amperometric detection
- Simultaneous determination of proline and pipemidic acid in human urine by capillary electrophoresis with electrochemiluminescence detection
- Simple method for the determination of pipemidic acid in biological fluids by high-performance liquid chromatography
- Electrochemiluminescence determination of pipemidic acid using sulfite as energy transfer mediator
- Multicommuted optosensor for the determination of pipemidic acid in biological fluids
- Study of the first antibacterial agent pipemidic acid modifying Keggin polyoxometalate
- Synthesis and spectroscopic studies of iron (III) complex with a quinolone family member (pipemidic acid)
- Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity
- Ligation of the quinolone antibacterial agent pipemidic acid to Keggin polyoxotungstates
- Synthesis and spectroscopic study of copper(II) and manganese(II) complexes with pipemidic acid
- Liver initiation activity of norfloxacin but not nalidixic acid, pipemidic acid, and ciprofloxacin on in vivo short-term liver initiation assay in rats
- Chemiluminescence flow-through sensor for pipemidic acid using solid sodium bismuthate as an oxidant
- Estimation of pipemidic acid and N-nitrosopipemidicacid by high-performance liquid chromatography
- Determination by high-performance liquid chromatography of pipemidic acid in human serum and urine
- The enhancement of pipemidic acid permeation into the pig urinary bladder wall
- Pipemidic acid hydrochloride
- A general practitioner multicenter study: Fosfomycin trometamol single dose versus pipemidic acid multiple dose
- In vitro activity of norfloxacin in urine compared to that of cinnoxacin, nalidixic acid and pipemidic acid
- Determination of pipemidic acid based on flow-injection chemiluminescence due to energy transfer from peroxynitrous acid synthesized on-line
- Flow Injection Chemiluminescence Determination of Pipemidic Acid Using On-Line Electrogenerated Cobalt(III) as Oxidant
- Complexation Study and Spectrofluorimetric Determination of Pipemidic Acid withγ-Cyclodextrin
- Microfluidic-enzymatic biosensor with immobilized tyrosinase for electrochemical detection of pipemidic acid in pharmaceutical samples
- Combination of pipemidic acid, colistin sodium methanesulfonate and nystatin may be less effective than nystatin alone for prevention of infection during chemotherapy-induced granulocytopenia in acute leukemia
- Comparative pharmacokinetic profiles of Cinoxacin and pipemidic acid in humans
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