Piperazine
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Clinical Pharmacology
Piperazine is an anthelmintic drug, effective for ascariasis and enterobiasis. It has a paralyzing effect on nematodes: disrupting the function of their neuromuscular system, causing muscle paralysis.
The severity of deworming drug is at the level of 90-95%, and with repeated use may be about 100%. Due to the fact that piperazine does not destroy ascaris, there is no danger of absorption of biological toxic products of their decay. Low toxicity.
Indications
Invasion by ascarids (ascariasis) and pinworms (enterobiasis).
Composition
1 tablet contains:
Active substance: piperazine adipat (piperazine adipate) - 500 mg;
Auxiliary substances: talc, calcium stearate, corn starch, carboxymethyl starch sodium (sodium starch glycolate).
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Dosage and Administration
With ascariasis in adults and children over 15 years appoint 1.5 - 2 g daily dose of 3-4 g
For children. Single and daily dose, respectively:from 3 years old - 0.3 and 0.6 g;4-5 years - 0.5 and 1 g;6-8 years - 0.75 and 1.5 g;9-12 years old - 1 and 2 g;13-15 years old - 1.5 and 3 g
In the treatment of ascariasis appoint 2 times a day for 1 hour or 0.5-1 hours after meals for 2 days in a row.
According to another scheme - once (0.4-4 g, depending on age) or 2 times 0.2-2 g. Forenterbiosis treatment prescribed in the same doses as with ascariasis, for 5 consecutive days with 7-day intervals between courses. Conduct 1-3 courses of therapy.
To remove pinworms from the rectum between courses of treatment at night put an enema of 1-3 glasses of water, with the addition of 1/2 teaspoon of sodium bicarbonate to 1 cup (baking soda).
Adverse reactions
Nausea, abdominal pain of spastic nature, headache.
In patients with renal failure - neurotoxic complications (muscle weakness, tremor, euphoria, hallucinations, blurred vision, impaired coordination of movements).
Contraindications
Children under the age of 3 years (for this dosage form).
Hypersensitivity, organic diseases of the central nervous system, chronic renal failure.
Drug interactions
Enhances the severity of extrapyramidal disorders caused by chlorpromazine.
Special instructions
Treatment of piperazine adipate does not require a special diet or patient preparation. Laxatives are prescribed only with a tendency to constipation.
During the treatment of enterobiosis follow a strict hygienic regime.
Treatment can be carried out on an outpatient basis.
Overdosage
Symptoms: tremor, muscle weakness.
Treatment: gastric lavage, taking activated charcoal or other enterosorbents, the appointment of saline laxatives. If necessary, oxygen and transfusion therapy. With neurological symptoms, thiamine is administered.
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