Buy Piperazine pills 500 mg, 10 pcs
  • Buy Piperazine pills 500 mg, 10 pcs

Piperazine

Pharmstandard
1311 Items
2019-09-19
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Clinical Pharmacology

Piperazine is an anthelmintic drug, effective for ascariasis and enterobiasis. It has a paralyzing effect on nematodes: disrupting the function of their neuromuscular system, causing muscle paralysis.

The severity of deworming drug is at the level of 90-95%, and with repeated use may be about 100%. Due to the fact that piperazine does not destroy ascaris, there is no danger of absorption of biological toxic products of their decay. Low toxicity.

Indications

Invasion by ascarids (ascariasis) and pinworms (enterobiasis).

Composition

1 tablet contains:

Active substance: piperazine adipat (piperazine adipate) - 500 mg;

Auxiliary substances: talc, calcium stearate, corn starch, carboxymethyl starch sodium (sodium starch glycolate).

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Piperazine

Dosage and Administration

With ascariasis in adults and children over 15 years appoint 1.5 - 2 g daily dose of 3-4 g

For children. Single and daily dose, respectively:from 3 years old - 0.3 and 0.6 g;4-5 years - 0.5 and 1 g;6-8 years - 0.75 and 1.5 g;9-12 years old - 1 and 2 g;13-15 years old - 1.5 and 3 g

In the treatment of ascariasis appoint 2 times a day for 1 hour or 0.5-1 hours after meals for 2 days in a row.

According to another scheme - once (0.4-4 g, depending on age) or 2 times 0.2-2 g. Forenterbiosis treatment prescribed in the same doses as with ascariasis, for 5 consecutive days with 7-day intervals between courses. Conduct 1-3 courses of therapy.

To remove pinworms from the rectum between courses of treatment at night put an enema of 1-3 glasses of water, with the addition of 1/2 teaspoon of sodium bicarbonate to 1 cup (baking soda).

Adverse reactions

Nausea, abdominal pain of spastic nature, headache.

In patients with renal failure - neurotoxic complications (muscle weakness, tremor, euphoria, hallucinations, blurred vision, impaired coordination of movements).

Contraindications

Children under the age of 3 years (for this dosage form).

Hypersensitivity, organic diseases of the central nervous system, chronic renal failure.

Drug interactions

Enhances the severity of extrapyramidal disorders caused by chlorpromazine.

Special instructions

Treatment of piperazine adipate does not require a special diet or patient preparation. Laxatives are prescribed only with a tendency to constipation.

During the treatment of enterobiosis follow a strict hygienic regime.

Treatment can be carried out on an outpatient basis.

Overdosage

Symptoms: tremor, muscle weakness.

Treatment: gastric lavage, taking activated charcoal or other enterosorbents, the appointment of saline laxatives. If necessary, oxygen and transfusion therapy. With neurological symptoms, thiamine is administered.

Studies and clinical trials of Piperazine (Click to expand)
  1. Curing of Epoxy Resins with Citric Acid-Piperazine Salt
  2. Raman Bandwidths of In-Phase ν1 Mode in Pinacol Hexahydrate and Piperazine Hexahydrate
  3. Vibrational spectra of the solid solution of (piperazine–pinacol) hexahydrate and polarons
  4. Piperazine-based homo- and copolymers containing trivalent and quaternary nitrogen functionalities
  5. Effect of acid acceptor on synthesis of new copolyamide with piperazine moiety
  6. In vitro and in vivo characterization of newly developed iodinated 1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}piperazine derivatives in rats: Limited value as dopamine transporter SPECT ligands
  7. Synthesis of a dopamine uptake inhibitor for PET studies: 1-[1-(2-benzo(b)thiophenyl)cyclohexyl]-4-(2-[18F]fluoroethyl) piperazine
  8. Preparation, properties and application of modified fibers with piperazine rings
  9. Enantioselective separation of 1,4-disubstituted piperazine derivatives on two cellulose Chiralcel OD and OJ and one amylose Chiralpak AD chiral selectors
  10. Liquid-Crystalline Properties of Unsaturated Piperazine-2,5-dione Derivatives
  11. Piperazine analog of vesamicol: In vitro and in vivo characterization for vesicular acetylcholine transporter
  12. Cyclic Trimers and Tetramers with Piperazine and 2-Butyne as Building Blocks
  13. Cyclic Trimers and Tetramers with Piperazine and 2-Butyne as Building Blocks
  14. Synthesis, Conformation and Equilibrium Study of New Piperazine and Azamacrocyclic Ligands with N-(Tetrahydro-2-oxofuran-3-yl) and N-[(Carboxy)(2-hydroxyethyl)methyl] Pendant Arms
  15. Ion exchange resins for gold cyanide extraction containing a piperazine functionality, 1. Synthesis and physico-chemical properties
  16. Ion Exchange Resins for Gold Cyanide Extraction Containing a Piperazine Functionality, 2. Study of the Gold Extraction Reaction
  17. Chelating properties of poly(N-acryloyl piperazine) by liquid-phase polymer-based retention (LPR) technique
  18. Hyperbranched Copolymers Made from A2, B2 and BB′2 Type Monomers, 3. Comparison of Copoly(sulfone-amine)s Containing Piperazine and 4,4′-Trimethylenedipiperidine Units
  19. Electrochemical Processes of Cadmium, Copper, Lead, and Zinc in the Presence of N-(2-Hydroxyethyl)piperazine-N ′-3-Propanesulfonic Acid (HEPPS): Possible Implications in Speciation Studies
  20. Determination of 1-(2-methoxyphenyl)-piperazine derivatives of airborne diisocyanates by packed capillary liquid chromatography with pre-column large-volume enrichment
  21. Solubility of carbon dioxide in aqueous piperazine solutions
  22. Absorber intercooling in CO2 absorption by piperazine-promoted potassium carbonate
  23. Absorption of carbon dioxide in aqueous piperazine/methyldiethanolamine
  24. Solubility of CO2 in (H2O+piperazine) and in (H2O+MDEA+piperazine)

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