Piroxicam
Akrikhin
1045 Items
2019-09-19
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Clinical Pharmacology
Piroxicam is a nonsteroidal anti-inflammatory and antirheumatic agent. It has anti-inflammatory, analgesic and antipyretic effects. It is used for rheumatic diseases, pain syndrome and articular syndrome.
Indications
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid and gouty arthritis, rheumatism, ankylosing spondylitis (Bechterew's disease), osteoarthritis. Pain syndrome: sciatica, tendovaginitis, bursitis, arthralgia, neuralgia, myalgia, sciatica, post-traumatic and postoperative pain syndrome, accompanied by inflammation, algomenorrhea. Feverish syndrome with colds and infectious diseases.
Composition
1 capsule contains: piroxicam 20 mg.
Excipients: powdered cellulose, sodium carboxymethyl starch (sodium starch glycolate), potato starch, sodium lauryl sulfate, magnesium stearate, gelatin, titanium dioxide or gelatin, titanium dioxide, blue patented dye.
Piroxicam is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Piroxicam acre | Akrikhin | Russia | capsules |
| Piroxicam | Drug Production | Russia | capsules |
| Finalgel | Boehringer Ingelheim | Austria | gel |
| Piroxicam | Vertex | Russia | gel |
| Piroxicam-verte | Vertex | Russia | gel |
| Piroxicam | Sopharma | Bulgaria | capsules |
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Dosage and Administration
Adults and children over 14 years old apply the gel to the skin over the affected area at a dose of 1 g (approximately the size of a hazelnut) 3-4 times / day.
The duration of treatment depends on the severity of symptoms and averages 2-3 weeks for tendinitis, tendovaginitis, and hip and shoulder syndrome, and 1-2 weeks for sports injuries.
Adverse reactions
Local reactions: irritation of the skin at the site of application of the drug (inflammation, redness, peeling).
Allergic reactions: urticaria, pruritus.
Contraindications
- renal failure;
- children's age up to 14 years;
- III trimester of pregnancy;
- hypersensitivity to acetylsalicylic acid or other NSAIDs;
- Hypersensitivity to piroxicam or other components of the drug.
Precautions should be prescribed to patients with asthma, allergic rhinitis, recurrent nasal polyposis and paranasal sinuses, chronic obstructive pulmonary diseases or chronic respiratory infections.
Pregnancy and Lactation
The drug is contraindicated for use in the third trimester of pregnancy. In the first and second trimesters, the drug should be used with caution.
Piroxicam in small quantities into breast milk. Therefore, it is not recommended to use Finalgel during breastfeeding.
Special instructions
Avoid getting the drug on damaged skin and eyes.
- Brand name: Piroxicam acre
- Active ingredient: Piroxicam
- Dosage form: Capsules
- Manufacturer: Akrikhin
- Country of Origin: Russia
Studies and clinical trials of Piroxicam (Click to expand)
- Raman and solid state 13C-NMR investigation of the structure of the 1 : 1 amorphous piroxicam : β-cyclodextrin inclusion compound
- Influence of environment on piroxicam polymorphism: Vibrational spectroscopic study
- Build-up of Polypeptide Multilayer Coatings with Anti-Inflammatory Properties Based on the Embedding of Piroxicam–Cyclodextrin Complexes
- Pharmacokinetics of Atenolol and Metoprolol Administered together with Piroxicam
- Piroxicam (Feldene) predisposes to chemotherapy-induced acute uric acid nephropathy
- Effect of piroxicam on gait in patients with osteoarthritis of the knee
- Rheumatoid arthritis treated with tenidap and piroxicam clinical associations with cytokine modulation by tenidap
- Tenidap in rheumatoid arthritis a 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone
- Effects of dose and sex on the pharmacokinetics of piroxicam in the rat
- Chemiluminescence method for the determination of piroxicam by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)–cerium(IV) system and its application
- Inhibitory and enhancing effects of piroxicam on whole blood chemiluminescence
- Recurrent small bowel obstruction associated with piroxicam
- Recurrent small bowel obstruction associated with piroxicam
- ChemInform Abstract: Synthesis and Structure Analysis of Cyclodehydration Product (II) of Piroxicam (I): A Metabolite Detected in Dogs and Monkeys.
- Influence of vehicles on the in vitro percutaneous absorption of piroxicam to optimise the formulation of patch tests in dermatology
- The effect of piroxicam on locomotor activity in rats with adjuvant-induced arthritis
- Voltammetric determination of piroxicam after incorporation within carbon pastes
- Contribution to the electrochemical behavior study of piroxicam in different aqueous-orgarnic media and electrodes by using polarographic and voltammetric techniques
- Determination of Piroxicam in Pharmaceutical Formulations Combining Amperometry and Multicommutation
- Microscopic Protonation/Deprotonation Equilibria of the Anti-Inflammatory Agent Piroxicam
- Transfer Mechanism of Ionic Drugs: Piroxicam as an agent facilitating proton transfer
- Piroxicam selectively inhibits the growth of premalignant and malignant human oral cell lines by limiting their progression through the S phase and reducing the levels of cyclins and AP-1
- Three-month, zero-order piroxicam release from monodispersed double-walled microspheres of controlled shell thickness
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