Midantan [Amantadine]
Merz
967 Items
2019-09-19
- done All payments are SSL encrypted
- done Full Refund if you haven't received your order
- done International shipping to the USA, UK and Europe
Clinical Pharmacology
Midantan - anti-parkinsonian.
Amantadine has an indirect agonistic effect on striaty dopamine receptors.
Increases the extracellular concentration of dopamine through both the intensification of its production and the blockade of dopamine reuptake by presynaptic neurons.
At therapeutic concentrations, amantadine slows down the production of acetylcholine and, thus, has an anticholinergic effect.
Indications
- It is used in Parkinson’s disease and parkinsonism of various etiologies. The drug is effective against the triad of symptoms observed in parkinsonism (mainly in rigid and akinetic forms, less effect on hyperkinetic syndrome — tremor)
- Residual symptoms and pain after stereotactic operations
- In combination therapy with PC-Mertz and levodopa preparations, side effects occurring during levodopa monotherapy may be prevented.
Composition
1 tablet, film coated, contains: Amantadine sulfate 100 mg
Excipients: Microcrystalline cellulose, potato starch, gelatin, lactose monohydrate, povidone, talc, magnesium stearate, colloidal silicon dioxide, croscarmellose sodium, titanium dioxide, butyl methacrylate copolymer, orange yellow dye
Amantadine is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| PK-Merz | Merz | Germany | pills |
| Midantan | BPMP | Belarus | pills |
No customer reviews for the moment.
Dosage and Administration
Orally, after eating with a small amount of liquid, preferably in the first half of the day.
The first 3 days - 1 tablet per day, then increase the dose to 2 pills per day, with a further dose increase of 1 tablet per week.
The usual effective dose is 1 to 3 pills twice a day.
The maximum daily dose is 600 mg.
In the case of combined treatment, it is necessary to determine the dose individually.
The last dose is recommended to be taken in the afternoon, no later than 16-00.
Use in elderly patients, in particular, in patients suffering from a state of excitement and confusion, predlaring and delirium. Lower dosage required.
Adverse reactions
Mental disorders accompanied by visual hallucinations. Rarely - motor and mental excitement. Retention of urine in patients with prostate adenoma. Heart failure. Arrhythmia, tachycardia, nausea, dry mouth, dizziness, sleep disturbance. Very rarely - the appearance of bluish color of the skin of the upper and lower extremities, a decrease in visual acuity.
Contraindications
Hypersensitivity to the drug.
Glaucoma, prostate adenoma. Psychomotor agitation. State preddeliry and delirium, psychosis in history. Epilepsy, thyrotoxicosis, acute and chronic diseases of the liver and kidneys. Pregnancy (1 trimester) and the period of breastfeeding.
Drug interactions
Simultaneous use of diuretics, which is a combination of triamterene / hydrochlorothizide, can lead to a change in the concentration of amantadine in plasma. In combination therapy with other anti-parkinsonian drugs, it may be necessary to change the doses of other drugs or the combination as a whole, otherwise side effects may increase.
Pregnancy and Lactation
Contraindicated in pregnancy and lactation.
Special instructions
Treatment of PC-Mertz should not be stopped suddenly, as this can lead to worsening of symptoms.
Patients suffering from cardiovascular diseases should be under constant medical supervision when prescribing PK Mertz.
Alcohol is contraindicated during treatment.
Influence on ability to drive motor transport and work with mechanisms. Be careful when using vehicle drivers and people whose profession is related to increased concentration of attention.
Overdosage
Symptoms: nausea, vomiting, tremor, ataxia, decreased visual acuity, lethargic condition, dysarthria, seizures, arrhythmia.
Treatment: gastric lavage, Activated charcoal intake, symptomatic therapy.
- Brand name: PK-Merz
- Active ingredient: Amantadine
- Dosage form: Coated pills.
- Manufacturer: Merz
- Country of Origin: Germany
Studies and clinical trials of Amantadine (Click to expand)
- Amantadine increases aromatic 1L-amino acid decarboxylase mRNA in PC12 cells
- Investigation of far red dyes for use in peroxyoxalate chemiluminescence detection and analysis of the CY5 derivative of amantadine hydrochloride in human plasma
- Combined antiinfluenza virus activity of Flos verbasci infusion and amantadine derivatives
- Transient benefit of amantadine in Parkinson's disease: The facts about the myth
- Amantadine is beneficial in restless legs syndrome
- Beneficial effects of amantadine on L-dopa-induced dyskinesias in Parkinson's disease
- Pathological gambling in Parkinson disease is reduced by amantadine
- Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study
- Is pathological gambling in Parkinson's disease reduced by amantadine?
- Four-year treatment of patients with parkinsonism using amantadine alone or with levodopa
- Review of 38 cases of subacute sclerosing panencephalitis: Effect of amantadine on the natural course of the disease
- Amantadine in essential tremor
- Amantadine in essential tremor
- Amantadine may be useful in essential tremor
- Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies
- Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent
- A revision of the metabolic disposition of amantadine
- Heterodimers of Histidine and Amantadine as Inhibitors for Wild Type and Mutant M2 Channels of Influenza A
- Determination of Amantadine Residue in Honey by Solid-phase Extraction and High-performance Liquid Chromatography with Pre-column Derivatization and Fluorometric Detection
- Amantadine increases striatal dopamine turnover in MPTP-treated mice
- Sequential Injection Lab-on-Valve Procedure for the Determination of Amantadine Using Potentiometric Methods
- Simultaneous determination of memantine and amantadine in human plasma as fluorescein derivatives by micellar electrokinetic chromatography with laser-induced fluorescence detection and its clinical application
- Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus
- Placebo-controlled trial of 400 mg amantadine combined with peginterferon alfa-2a and ribavirin for 48 weeks in chronic hepatitis C virus-1 infection
Customers who bought this product also bought:
7 other products in the same category:
arrow_upward