

Pharmacodynamics
Longidaza® has hyaluronidase (enzymatic) activity of prolonged action, chelating, antioxidant, immunomodulatory and moderately pronounced anti-inflammatory properties.
The prolongation of the enzyme action is achieved by covalent binding of the enzyme with a physiologically active polymeric carrier (azoxymer). Longidaza® shows anti-fibrotic properties, weakens the acute phase of inflammation, regulates (increases or decreases depending on the initial level) synthesis of inflammatory mediators (interleukin-1 and tumor necrosis factor - alpha), increases the humoral immune response and resistance of the organism to infection.
The pronounced anti-fibrotic properties of Longidaza are provided by conjugation of hyaluronidase with a carrier, which significantly increases the resistance of the enzyme to denaturing effects and to the action of inhibitors: Longididase enzymatic activity is maintained when heated to 37 ° C for 20 days, while native hyaluronidase loses its activity under the same conditions during the day. In the preparation of Longidaza, the simultaneous local presence of the enzyme hyaluronidase and a carrier is provided that is capable of binding enzyme inhibitors and stimulators of collagen synthesis (iron, copper, heparin, etc.) released during hydrolysis of the matrix components. Due to these properties, Longidase® not only has the ability to depolymerize the matrix of connective tissue in fibrous granulomatous masses, but also to suppress the reverse regulatory response, aimed at the synthesis of components of the connective tissue.
The specific substrate of testicular hyaluronidase is glycosaminoglycans (hyaluronic acid, chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate), which form the basis of the connective tissue matrix. As a result of depolymerization (breaking the bond between C1 acetylglucosamine and C4 glucuronic or induronic acids), glycosaminoglycans change their basic properties: viscosity decreases, the ability to bind water decreases, metal ions temporarily increase the permeability of tissue barriers, facilitates the movement of fluid in the intercellular space, increases the elasticity of connective tissue , which is manifested in a decrease in swelling of the tissue, flattening of scars, an increase in the volume of movement of the joints, a decrease in contractures and ezhdenii their formation, reduction of adhesions. Biochemical, immunological, histological and electron microscopic studies have shown that Longidase® does not damage normal connective tissue, but causes destruction of the composition and structure of the connective tissue in the area of fibrosis.
Longidis® does not have mutagenic, embryotoxic, teratogenic and carcinogenic effects.
The drug is well tolerated by patients, there are no local and general allergic reactions.
The use of Longidaza in therapeutic doses during or after surgical treatment does not cause deterioration of the postoperative period or progression of the infectious process; does not slow down the recovery of bone tissue.
Pharmacokinetics
An experimental study of pharmacokinetics has made it possible to establish that when administered rectally, the drug Longidase® is characterized by a high rate of distribution in the body, is well absorbed into the systemic circulation and reaches its maximum concentration in the blood after 1 hour. The half-distribution period is about 0.5 hours, the half-elimination period is from 42 to 84 hours. Excreted mainly by the kidneys.
The drug penetrates into all organs and tissues, including it passes through the blood-brain and blood-brain barriers. Established the absence of tissue cumulation.
The bioavailability of the drug Longidase® with rectal administration is high: about 90%.
Adults and adolescents over 12 years of age in the form of monotherapy and as part of the complex therapy of diseases involving connective tissue hyperplasia, including against the background of the inflammatory process:
The composition of one suppository:
Active ingredient: Bovgialuronidazozoksimer (Longidaza®) - 3000 IU
Auxiliary substance: cocoa butter - to obtain a suppository weighing 1.3 g
Description: torpedo-shaped suppositories, light yellow in color with a slight specific smell of cocoa butter, marbling staining is allowed.
Polyoxidonium® is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Polyoxidonium® | NPO Petrovax Farm | Russia | suppositories |
Polyoxidonium® | NPO Petrovax Farm | Russia | pills |
Polyoxidonium® | NPO Petrovax Farm | Russia | lyophilisate |
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Use the drug only according to the indications, the method of application and in those doses that are specified in the instructions.
If there is no improvement after treatment, or symptoms become worse, or new symptoms appear, you should consult your doctor.
Orally and sublingually for 20-30 minutes before meals daily 2 times a day: for children over 10 years old and for adults - 1 tablet, for children from 3 to 10 years old - ½ tablet (6 mg).
If necessary, repeated courses of therapy are possible in 3-4 months. When you reappoint the drug its effectiveness is not reduced.
Recommended treatment regimens
Sublingual
For adult treatment:
For the treatment of children from 3 to 10 years:
For treatment of children older than 10 years:
For prophylaxis for adults:
For prevention for children from 3 to 10 years:
For prophylaxis to children over 10 years old:
Orally
For adult treatment:
For treatment of children older than 10 years:
No side effects reported.
Carefully
If you have the diseases listed in this section, consult your doctor before you start taking the medicine:
- chronic renal failure (not more often used 2 times a week).
Azoximer bromide does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, cytochrome P-450 isoenzymes, therefore the drug is compatible with antibiotics, antiviral, antifungal and antihistamines, glucocorticosteroids and cytostatics.
The use of the drug Polyoxidonium® is contraindicated in pregnant women and women during breastfeeding (there is no clinical experience).
In experimental use of the drug Polyoxidonium® in animals, no embryotoxic and teratogenic effects or effects on the development of the fetus were detected.
Before using Polyoxidonium®, if you are pregnant, or suggest that you might be pregnant, or are planning to become pregnant, you should consult with your doctor.
During the period of breastfeeding, before using the drug Polyoxidonium®, it is necessary to consult a doctor.
With the development of an allergic reaction, discontinue use of the drug Polyoxidonium® and consult a doctor.
Cases of overdose are not registered.
Studies and clinical trials of Polyoxidonium (Click to expand)