Povidone-iodine
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Clinical Pharmacology
Farm group: antiseptic.
Pharmaceutical action: Iodine in the form of a complex polyvinylpyrrolidone iodine. The concentration of active iodine is 0.1-1%.
It has antiseptic, disinfectant, antifungal and antiprotozoal effects. Blocks the amino group of cellular proteins. Possesses a wide range of antimicrobial action.
Active against bacteria (including E. coli, Staphylococcus aureus), fungi, viruses, protozoa.
Polyvinylpyrrolidone iodine refers to the iodophore that bind iodine. Upon contact with skin and mucous membranes, iodine is gradually and evenly released, exerting a bactericidal effect on microorganisms. At the site of application, a thin colored layer remains, which persists until the entire amount of iodine is released.
Indications
Povidone-iodine solution for external use 10%:
- treatment and prevention of wound infections in surgery, traumatology, combustiology, dentistry;
- treatment of bacterial, fungal and viral infections of the skin, prevention of superinfection in dermatological practice;
- treatment of bedsores, trophic ulcers, diabetic foot;
- disinfection of the skin and mucous patients in preparation for surgical interventions, invasive examinations (puncture, biopsy, injection, etc.);
- disinfection of the skin around the catheters, drains, probes;
- disinfection of the oral cavity during dental operations;
- disinfection of the birth canal during the "minor" gynecological operations (artificial abortion, the introduction of the intrauterine device, the coagulation of erosion or polyp, etc.).
Composition
100 ml:
Povidone-iodine 10 g
Excipients: nonoxynol, glycerol, disodium hydrogen phosphate 12-hydrate, citric acid, sodium hydroxide, demineralized water.
Povidone-iodine is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Povidone-iodine | Hemofarm | Serbia | vials |
Braunadine | ointment | ||
Braunadine | solution | ||
Betadine | Egis | Hungary | suppositories |
Betadine | Egis | Hungary | solution |
Betadine | Egis | Hungary | ointment |
Iodoxide | Nizhpharm | Russia | suppositories |
Aquazan | Iodine technology and marketing | Russia | solution |
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Dosage and Administration
After the preliminary hygienic treatment, the suppositories are inserted deep into the vagina.
For acute vaginitis, 1 vaginal suppository is prescribed 2 times / day for 7 days.
For subacute and chronic vaginitis, 1 suppository is prescribed 1 time / day before bedtime for 14 days. If necessary, treatment can be extended.
Adverse reactions
Possible: local manifestation of an allergic reaction to iodine (itching, flushing), which requires discontinuation of the drug.
Contraindications
- hyperthyroidism;
- thyroid adenoma;
- Herpetiform dermatitis Dühring;
- simultaneous use of radioactive iodine;
- children's age up to 8 years;
- hypersensitivity to iodine and other components of the drug.
The drug should be used with caution during pregnancy and lactation (breastfeeding).
Drug interactions
Betadine is incompatible with other disinfectants and antiseptics, especially those containing alkalis, enzymes and mercury.
Pregnancy and Lactation
Betadine is not recommended for use since 3 months of pregnancy and during lactation. If it is necessary to conduct therapy, the doctor decides on the prescription of the drug individually.
It is necessary to control the function of the thyroid gland in newborns and infants whose mothers used Betadine.
Special instructions
During the use of suppositories, you can recommend the use of sanitary pads.
Use in Pediatrics
Perhaps the use of girls aged 8 years and older, being careful with the introduction of virgins.
- Brand name: Povidone-iodine
- Active ingredient: Povidone-iodine
- Manufacturer: Hemofarm
- Country of Origin: Serbia
Studies and clinical trials of Povidone-iodine (Click to expand)
- Protective effect of povidone iodine ointment against skin lesions induced by chemical and thermal stimuli
- Prophylactic interparietal povidone-iodine in abdominal surgery
- The bacteriology of primary wound sepsis in potentially contaminated abdominal operations: The effect of irrigation, povidone-iodine and cephaloridine on the sepsis rate assessed in a clinical trial
- A comparison of noxythiolin and povidone-iodine in experimentally induced peritoneal infection in mice
- Prevention of intraperitoneal adhesions: A comparison of noxythiolin and a new povidone-iodine/PVP solution
- Short term metronidazole therapy contrasted with povidone-iodine spray in the prevention of wound infection after appendicectomy
- The effect of topical povidone-iodine on the incidence of infection in surgical wounds
- The effect of topical povidone iodine on wound infection following abdominal surgery
- Combined topical povidone–iodine and systemic antibiotics in postappendicectomy wound sepsis
- Povidone-iodine in experimental peritoneal hydatidosis
- Meta-analysis of intraoperative povidone–iodine application to prevent surgical-site infection
- Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone–iodine in clean-contaminated surgery
- Letter 1: Systematic review and meta-analysis of preoperative anti- sepsis with chlorhexidine versus povidone–iodine in clean-contaminated surgery (Br J Surg 2010; 97: 1614–1620)
- Letter 2: Systematic review and meta-analysis of preoperative anti- sepsis with chlorhexidine versus povidone–iodine in clean-contaminated surgery (Br J Surg 2010; 97: 1614–1620)
- Letter 3: Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone–iodine in clean-contaminated surgery (Br J Surg 2010; 97: 1614–1620)
- Authors' reply: Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone–iodine in clean- contaminated surgery (Br J Surg 2010; 97: 1614–1620)
- Meta-analysis of intraoperative povidone–iodine application to prevent surgical-site infection (Br J Surg 2010; 97: 97 1603–1613)
- Authors' reply: Meta-analysis of intraoperative povidone–iodine application to prevent surgical-site infection (Br J Surg 2010; 97: 1603–1613)
- Sequential flow-injection potentiometric determination of iodide and iodine in povidone iodine pharmaceuticals
- Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus
- Genetic effects of povidone-iodine
- Absence of povidone-iodine-induced mutagenicity in mice and hamsters
- Structure of polyvinylpyrrolidone-iodine (povidone-iodine)
- Effects of betadine on vaginal flora : Monif G, Thompson J, Stephens H, Baer H: Quantitative and qualitative effects of povidone iodine liquid and gel on the aerobic and anaerobic flora of the female genital tract. Am J Obstet Gynecol 137:432, 1980.