Buy Protamine Sulfate suspension 10 mg/ml ampoules 5 ml 5 pcs
  • Buy Protamine Sulfate suspension 10 mg/ml ampoules 5 ml 5 pcs

Protamine Sulfate

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Clinical Pharmacology

Protamine sulfate is a specific heparin antagonist. 1 mg protamine sulfate neutralizes 80-120 IU of heparin in the blood. Complexation is due to the abundance of cationic groups (due to arginine), which bind to the anionic centers of heparin. The effect of the drug after intravenous administration occurs instantly ("on the needle") and lasts for 2 hours. After intravenous administration, a protamine-heparin complex is formed, which can be destroyed with the release of heparin. In case of an overdose, it can reduce blood clotting, since protamine sulfate itself exhibits anticoagulant activity.

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Protamine Sulfate

Dosage and Administration

A solution of protamine sulfate is injected slowly intravenously by jet or drip. The rate of administration should not exceed 5 mg per minute (for example, 50 mg of the drug should be administered within 10 minutes), since a faster administration may cause an anaphylactoid reaction. The dose of the drug depends on the route of administration of heparin. The calculated dose is dissolved in 300-500 ml of 0.9% sodium chloride solution. Do not administer more than 150 mg protamine sulfate in 1 hour.

1. With bolus injections of heparin, the dose of protamine sulfate decreases depending on the time elapsed from the administration of heparin, since the latter is continuously removed from the body.

Time elapsed after heparin injection Dose of protamine sulfate per 100 IU of heparin

15-30 minutes 1-1.5 mg

30-60 minutes 0.5-0.75 mg

Over 2 hours 0.25-0.375 mg

2. If heparin was injected intravenously, it is necessary to stop its infusion and inject 25-30 mg of protamine sulfate.

3. For subcutaneous injections of heparin, the dose of protamine sulfate is 1 - 1.5 mg for every 100 IU of heparin. The first 25-50 mg of protamine sulfate should be administered intravenously slowly, and the remaining dose should be administered intravenously over 8-16 hours. Perhaps fractional introduction of protamine sulfate, which requires control of activated partial thromboplastin time (APTT). For example, if 20,000 IU of heparin is injected subcutaneously, after 2 hours, heparin is resorbed from complexes with protamine at 3333 IU of heparin, therefore the next dose of protamine sulfate is 33 mg.

4. In the case of using extracorporeal circulation during surgery, the dose of protamine sulfate is 1.5 mg for every 100 IU of heparin. When determining the dose of protamine, it is necessary to take into account the route of administration of heparin.

Studies and clinical trials of Protamine Sulfate (Click to expand)
  1. A demonstration of androgen and estrogen receptors in a human breast cancer using a new protamine sulfate assay
  2. Vacuolation in normal mast cells and in mast cells treated with protamine sulfate
  3. The safety of protamine sulfate in diabetics undergoing cardiac catheterization
  4. Protamine sulfate and nph insulin
  5. Complement activation from protamine sulfate administration after coronary angiography
  6. Ferumoxides–protamine sulfate is more effective than ferucarbotran for cell labeling: implications for clinically applicable cell tracking using MRI
  7. Protamine sulfate inhibits mitogenic activities of the extracellular matrix and fibroblast growth factor, but potentiates that of epidermal growth factor
  8. Light-scattering investigation of protamine sulfate
  9. Comparative neutralization of lung-and mucosal-derived heparin by protamine sulfate using in vitro and in vivo methods
  10. Expression of transferrin receptor and ferritin following ferumoxides–protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging
  11. Labeling of cells with ferumoxides–protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells
  12. Protamine sulfate precipitation: A new assay for the Ah receptor
  13. Protamine sulfate/poly(l-aspartic acid) polyionic complexes self-assembled via electrostatic attractions for combined delivery of drug and gene
  14. Concentrations of Amino Acids in Extracellular Fluid After Opening of the Blood-Brain Barrier by Intracarotid Infusion of Protamine Sulfate
  15. Hydrogen/deuterium exchange on protein solutions containing nucleic acids: utility of protamine sulfate
  16. Effect of protamine sulfate on the permeability properties of the mammalian urinary bladder
  17. Leakage of blood-retinal barrier due to damaging effect of protamine sulfate on the endothelium
  18. Experimental potentiation of the hyperglycemic action of diabetogenic factor by protamine sulfate
  19. Protamine sulfate-induced enzyme secretion from rabbit neutrophils
  20. Potentiating action of protamine sulfate on nucleic acid induced, non-specific resistance
  21. Histamine release from rat mast cells induced by protamine sulfate and polyethylene imine
  22. Thrombocytopenia accompanying a reaction to protamine sulfate
  23. Protamine sulfate causes endothelium-indepen-dent vasorelaxation via inducible nitric oxide syn-thase pathway

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