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Pylobact has an anti-ulcer, anti-helicobacter action.
Omeprazole inhibits the secretion of gastric acid due to the specific inhibition of H + K + -ATPase - an enzyme located in the membranes of the parenteral cells of the gastric mucosa. Reduces basal and stimulated secretion regardless of the nature of the stimulus. After a single dose of the drug inside omeprazole occurs within the first hour and lasts for 24 hours, the maximum effect is achieved after 2 hours. After cessation of the drug, secretory activity is fully restored in 3-5 days.
Clarithromycin - semisynthetic antibiotic from the group of macrolides of a broad spectrum of activity. It has an antimicrobial effect, which is associated with the suppression of protein synthesis by interacting with the 50S ribosomal subunit of the microbial cell. Effective against a large number of gram-positive, gram-negative aerobic and anaerobic microorganisms, including Helicobacter pylori. The metabolite 14-hydroxylarithromycin formed in the body also has a pronounced antimicrobial activity.
Tinidazole inhibits synthesis and damages the DNA structure of bacteria. It is active against anaerobic bacteria, protozoa and Helicobacter pylori.
Eradication therapy of Helicobacter pylori in duodenal ulcer.
Combined set (daily dose)
1 capsule contains:
Active substance: omeprazole 20 mg;
1 tablet contains:
Active substance: clarithromycin 250 mg;
1 tablet contains:
Active substance:tinidazole 500 mg.
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Dosage and Administration
Each strip of Pylobact contains two capsules of omeprazole (20 mg each), two pills of clarithromycin (250 mg each) and two pills of tinidazole (500 mg each), and is intended for 1 day of treatment.
Take orally one capsule of omeprazole, one tablet of clarithromycin and one tablet of tinidazole 2 times a day during or after meals in the morning and evening. pills and capsules can not be broken and chewed, they should be swallowed whole.
Duration of treatment is 7 days.
On the part of the digestive system: dysbacteriosis, diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbance, metallic taste in mouth, loss of appetite, stomatitis, transient increase in liver enzymes in plasma, impaired liver function, hepatitis (a. t. including jaundice), in patients with previous liver disease - encephalopathy; rarely pseudomembranous enterocolitis.
From the side of the central nervous system: headache, dizziness, agitation, fatigue, weakness, drowsiness, insomnia, ataxia, paresthesias, depression, confusion, hallucinations, epileptic reactions, peripheral neuropathy, convulsions, fear, nightmares, disorientation, psycho, depersonalization, noise in the ears.
From the musculoskeletal system: muscle weakness, myalgia, arthralgia.
From the hemopoietic system: leukopenia, neutropenia, thrombocytopenia, thrombocytopenic purpura, anemia.
On the part of the skin: itching; rarely - skin rash; in some cases - photosensitization, erythema multiforme exudative, alopecia.
Allergic reactions: urticaria, angioedema, bronchospasm and anaphylactic shock.
Other: tachycardia, interstitial nephritis, visual impairment, peripheral edema, increased sweating, fever, gynecomastia.
- hypersensitivity to omeprazole, clarithromycin or tinidazole, as well as to macrolide antibiotics;
- combined use with cisapride, pimozide, astemizole, terfenadine, ethanol is prohibited;
- lactation period;
- organic diseases of the central nervous system;
- oppression of bone marrow hematopoiesis;
- renal and / or liver failure.
Before starting therapy, it is necessary to exclude the presence of a malignant process, since treatment, masking the symptoms, may delay the correct diagnosis.
- Brand name: Pylobact®
- Active ingredient: Clarithromycin, Omeprazole, Tinidazole
- Dosage form: A set of pills and capsules
- Manufacturer: Ranbaxy Laboratories Ltd
- Country of Origin: India