Buy Pyrazidol pills 25 mg, 50 pcs
  • Buy Pyrazidol pills 25 mg, 50 pcs

Pyrazidol® [Pirlindole]

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Clinical Pharmacology

Pyrazidol - thymoleptic, antidepressant.

Selectively inhibits type A MAO, blocks deamination of serotonin and norepinephrine, and to a lesser extent, tyramine. Partially inhibits monoamine reuptake, potentiates the effects of norepinephrine precursor - dioxyphenylalanine (L-DOPA) and serotonin precursor - 5-hydroxytryptophan. Stimulates adreno-and serotoninergichesky structures. It activates the processes of synaptic transmission of nervous excitation in the central nervous system. It has a nootropic effect, improves cognitive function.


Thymoleptic effect is combined with a balanced effect on the central nervous system (activating effect in patients with apathetic, anergic depressions or a sedative effect in patients in the agitated state).


Depression, incl. senile, involutional, occurring predominantly with psychomotor retardation and asthenic disorders, anxiety-depressive or anxious-delusional components, alcohol withdrawal syndrome, Alzheimer's disease (as part of complex therapy).


Active substance: Pirlindole;

Excipients: milk sugar; potato starch; calcium stearate

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Pyrazidol® [Pirlindole]

Dosage and Administration

For oral use, at 0.05–0.075 g / day in 2 divided doses, gradually increasing the dose by 0.025–0.05 g to 0.15–0.30 g / day. The maximum daily dose is 0.4 g divided into 2–3 doses. After achieving a therapeutic effect, treatment is continued for 2-4 weeks, after which the dose is gradually reduced.

Adverse reactions

Dry mouth, nausea, sweating, hand tremor, tachycardia, dizziness, allergic reactions.


Hypersensitivity, acute hepatitis, blood diseases, simultaneous administration of MAO inhibitors.

Drug interactions

Increases the effectiveness of epinephrine (due to anti-monoamine oxidase activity). Compatible with antipsychotics, anxiolytics. Incompatible with antidepressants - MAO inhibitors, furazolidone, procarbazine, selegiline.

Pregnancy and Lactation

Adequate and strictly controlled studies on the safety and efficacy of the drug during pregnancy and lactation have not been conducted.

Special instructions

Pyrazidol is not prescribed simultaneously with MAO antidepressant inhibitors, furazolidone, procarbazine, selegiline.

Perhaps the use of pyrazidol in patients with glaucoma and benign prostatic hyperplasia.

Pirazidol is compatible with antipsychotics, anxiolytics.

  • Brand name: Pyrazidol
  • Active ingredient: Pirlindole
  • Dosage form: pills
  • Manufacturer: Pharmstandard
  • Country of Origin: Russia

Studies and clinical trials of Pirlindole (Click to expand)

  1. Double-Blind Randomized Controlled Pilot Study of the Efficacy and Tolerability of Pirlindole, a Reversible Inhibitor of Monoamine Oxidase A, and Mianserin, in the Treatment of Depression
  2. ChemInform Abstract: First Preparative Enantiomer Resolution of Pirlindole, a Potent Antidepressant Drug.
  3. ChemInform Abstract: Inhibition of Monoamine Oxidase by Pirlindole Analogues: 3D-QSAR and CoMFA Analysis.
  4. ChemInform Abstract: Domestic Antidepressants: Part 2. Pyrazidole (Pirlindole)
  5. Persistence of central effects of pirlindole, a short-acting monoamineoxidase inhibitor, in the presence of a monoamineoxidase inhibitor
  6. Determination of pirlindole in plasma and urine by high-performance liquid chromatography
  7. Automated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column
  8. Simultaneous determination of pirlindole enantiomers and dehydropirlindole by chiral liquid chromatography
  9. Enantiomeric separation of pirlindole by liquid chromatography using different types of chiral stationary phases
  10. Effects of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase-a and on GABAAreceptors
  11. Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition
  12. Domestic Antidepressants. 2. Pyrazidole (Pirlindole)
  13. Monoamine oxidase A inhibitory potency and flavin perturbation are influenced by different aspects of pirlindole inhibitor structure
  14. Pre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death
  15. Preparative resolution of racemic pirlindole: Chromatrographic methods and determination of the absolute configuration: P. de Tullio∗, A. Ceccato$, J.-F. Liégeois∗, B. Pirotte∗, A. Felikidis∗, M. Stachow∗, P. Hubert$, J. Crommen$, J. Géczy£, J. Delarge∗. ∗ Deparment of Medicinal Chemistry, University of Liège, 3 rue Fusch, B-4000 Liège, Belgium. $ Department of Drug Analysis, University of Liège, Avenue de l'Hôpital, B-4000 Liège-1, Belgium. £ Therabel Research, 110 rue Egide van Ophem, B-1180 Bruxelles, Belgium
  16. A double-blind randomized placebo-controlled study of the efficacy and safety of pirlindole, a reversible monoamine oxidase A inhibitor, in the treatment of depression
  17. Double-blind randomized controlled study of the efficacy and tolerability of two reversible monoamine oxidase A inhibitors, pirlindole and moclobemide, in the treatment of depression
  18. First Preparative Enantiomer Resolution of Pirlindole, a Potent Antidepressant Drug
  20. Pirlindole in the Treatment of Depression
  21. Pirlindole in the Treatment of Depression and Fibromyalgia Syndrome
  22. Inhibition of Monoamine Oxidase by Pirlindole Analogues: 3D-QSAR and CoMFA Analysis
  23. Efficacy of Pirlindole, a Highly Selective Reversible Inhibitor of Monoamine Oxidase Type A, in the Prevention of Experimentally Induced Epileptic Seizures

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