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Pyridoxine, Thiamine, Cyanocobalamin

G.L.Farma GmbH
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Clinical Pharmacology

Pharmacological action is determined by the properties of vitamins that make up the drug. The drug contains vitamins B1 (thiamine), B6 ​​(pyridoxine) and B12 (cyanocobalamin), the deficiency of which can lead to neurological disorders, mainly from the peripheral nervous system.

Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and locomotor system. Contribute to increased blood flow and improve the functioning of the nervous system.

Thiamine is a cofactor of enzymes that transfer two-carbon groups in decarboxylation reactions, plays a key role in the metabolism of carbohydrates, as well as in the Krebs cycle with subsequent participation in the synthesis of TPF (thiamine pyrophosphate) and ATP (adenosine triphosphate).

Pyridoxine is a transaminase cofactor, is involved in protein metabolism, and partly in carbohydrate and fat metabolism.

The physiological function of both vitamins is the potentiation of the action of each other, manifested in a positive effect on the nervous, neuromuscular and cardiovascular systems.

The drug quickly makes up for the deficiency of these vitamins.

Cyanocobalamin is a cofactor in the transfer reactions of one-carbon groups, participates in the synthesis of the myelin sheath, stimulates hematopoiesis, reduces pain associated with damage to the peripheral nervous system, stimulates nucleic acid metabolism through activation of folic acid.


After intramuscular administration, thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml 15 minutes on the first day of a 50 mg dose) and is unevenly distributed in the body when it is 15% in leukocytes, 75% in erythrocytes and in plasma %

Thiamine penetrates the blood-brain and plancentric barriers and is found in breast milk. Thiamine is excreted in the urine in the alpha phase after 0.15 hours, in the beta phase after 1 hour and in the terminal phase for 2 days. The main metabolites are thiamincarboxylic acid, pyramine and some unknown metabolites. Of all the vitamins, thiamine is stored in the body in the smallest amounts. An adult human body contains about 30 mg of thiamine as 80% thiamine pyrophosphate, 10% thiamine triphosphate and the rest as thiamine monophosphate.

After intramuscular administration, pyridoxine is rapidly absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation of the CH2OH group in the 5th position, forms a metabolically active pyridoxal phosphate. About 80% of the vitamin is bound to plasma proteins.

Pyridoxine is distributed throughout the body and crosses the placenta and is found in human milk, deposited in the liver and oxidized to 4-pyridoxine acid, which is excreted in the urine, a maximum of 2 to 5 hours after absorption. The human body contains 40-150 mg of vitamin B6 and its daily elimination rate is about 1.7-3.6 mg with a replenishment rate of 2.2-2.4%.

After parenteral administration, cyanocobalamin forms complexes with the transport protein transcobalamin, which are rapidly absorbed by the liver, bone marrow and other organs. Cyanocobalamin is excreted in the bile and is involved in the enterohepatic circulation. Penetrates through the placenta.


In the treatment of the following neurological diseases, accompanied by a deficiency of B vitamins:

- polyneuropathy (diabetic, alcoholic);

- intercostal neuralgia;

- trigeminal neuralgia;

- neuritis of the facial nerve;

- radicular syndrome caused by degenerative changes of the spine;

- cervical syndrome;

- shoulder and shoulder syndrome;

- lumbar syndrome;

- lumboishalgia.


1 ampoule contains:

active ingredients:

thiamine hydrochloride 100.00 mg

pyridoxine hydrochloride 100.00 mg

cyanocobalamin 1.00 mg


diethanolamine 5.0 mg

water for injection up to 2.0 ml

Pyridoxine, Thiamine, Cyanocobalamin is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Neuromultivit G.L.Farma GmbH Austria solution
Neurobion® Merck KGaA Russia pills
Neurobion® Merck KGaA Russia solution

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Pyridoxine, Thiamine, Cyanocobalamin

Dosage and Administration

Dissolve the tablet in 15 ml of solvent.

Instill 1-2 drops of the resulting solution 3-5 times a day.

Adverse reactions

Maybe: marginal blepharitis, conjunctival injection, burning sensation, itching.

Hypersensitivity to Pirenoxinee.

Special instructions

When digging in, avoid contacting the pipette tip with the eye.

  • Brand name: Pyrazinamide
  • Active ingredient: Pyrazinamide
  • Dosage form: Pills.
  • Manufacturer: Ozone
  • Country of Origin: Russia

Studies and clinical trials of Pyridoxine, Thiamine, Cyanocobalamin (Click to expand)

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