Pyrithione zinc
Pharmstandard-Tomsk
783 Items
2019-09-19
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Clinical Pharmacology
Cinocap has anti-inflammatory, antibacterial and antifungal activity. Antibacterial activity of zinc pyrithione is manifested against a number of gram-positive and gram-negative bacteria: Streptococcus spp, Staphylococcus spp, Escherichia coli, Pseudomonas aeruginosa, Proteus spp.
Pyrithione zinc reduces the intracellular level of ATP, contributes to the depolarization of cell membranes, causing the death of fungi and bacteria. Antifungal activity is particularly pronounced with the action on Pityrosporum ovale and Pityrosporum orbiculare, causing inflammation and excessive flaking with dandruff, seborrheic dermatitis, psoriasis, and other skin diseases. The mechanism of anti-inflammatory action has not been studied.
Indications
- Psoriasis.
- Atopic dermatitis (eczema, neurodermatitis).
- Seborrheic dermatitis.
- Dry skin.
Composition
100 g of cream contains: pyrithione zinc (in terms of 100% substance) - 0.2 g (0.2%).
Excipients: macrogol cetostearate, cetostearyl alcohol
Pyrithione zinc is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Cinocap | Pharmstandard-Tomsk | Russia | cream |
| Skin cap | Recife Parets S.L | Spain | spray can |
| Cinocap | Pharmstandard | Russia | spray can |
| Skin cap | B. Braun Medical SA | Spain | cream |
| Skin cap shower gel | Heminova Internationale SA | Spain | gel |
| Skin cap (B. Braun Medical SA | B. Braun Medical SA | Spain | shampoo |
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Dosage and Administration
The drug is intended for external use. Adults and children from 1 year old: apply a thin layer of the cream on the affected areas 2-3 times a day.
Psoriasis: 1-1.5 months, repeated courses - when signs of exacerbation appear.
Atopic dermatitis: 3-4 weeks.
Seborrheic dermatitis: 2 weeks.
Adverse reactions
The drug is usually well tolerated. Sometimes there are allergic reactions.
Contraindications
- Hypersensitivity.
- Children's age up to 1 year.
- Brand name: Cinocap
- Active ingredient: Pyrithione zinc
- Dosage form: Cream.
- Manufacturer: Pharmstandard-Tomsk
- Country of Origin: Russia
Studies and clinical trials of Pyrithione zinc (Click to expand)
- Determination of Zinc Pyrithione in Hair Care Products on Metal Oxides Modified Carbon Electrodes
- Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis)
- Evaluation of the genotoxic potential of zinc pyrithione in the Salmonella mutagenicity (Ames) assay, CHO/HGPRT gene mutation assay and mouse micronucleus assay
- Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry
- Aqueous phototransformation of zinc pyrithione: Degradation kinetics and byproduct identification by liquid chromatography–atmospheric pressure chemical ionisation mass spectrometry
- Design and synthesis of novel perfluoroalkyl-containing zinc pyrithione biocide
- Analysis of zinc pyrithione in shampoos by reversed-phase high-performance liquid chromatography
- Determination of zinc pyrithione in cosmetic products by high-performance liquid chromatography with pre-labelling
- High-performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation
- Detection of clobetasol propionate as an undeclared steroid in zinc pyrithione formulations by high-performance liquid chromatography with rapid-scanning ultraviolet spectroscopy and mass spectrometry
- Determination of the antifouling agent zinc pyrithione in water samples by copper chelate formation and high-performance liquid chromatography–atmospheric pressure chemical ionisation mass spectrometry
- The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial
- The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo
- Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations
- Electrospray ionization mass spectrometric observation of ligand exchange of zinc pyrithione with amino acids
- Effect of zinc pyrithione on mitotic activity in normal human skin
- Pseudomonas aeruginosaPAO1 Resistance to Zinc Pyrithione: Phenotypic Changes Suggest the Involvement of Efflux Pumps
- Increased scalp skin lipids in response to antidandruff treatment containing zinc pyrithione
- Zinc pyrithione induces apoptosis and increases expression of Bim
- Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes
- Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis
- In vitroantifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole againstMalassezia globosaandMalassezia restrictareference strains
- The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells
- Pustular psoriasis and the Köbner phenomenon caused by allergic contact dermatitis from zinc pyrithione-containing shampoo
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