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The active ingredient of the drug Isentress - raltegravir, inhibits the catalytic activity of the enzyme involved in the replication (replication) of the HIV virus - HIV integrase. Inhibition of the latter prevents the covalent introduction or integration of the HIV genome into the host cell genome in the early stages of infection. HIV genomes not introduced into human DNA cannot produce new viral particles, thus, inhibition of the integration process blocks the further spread of viral infection in the body. With respect to human phosphotransferases, including DNA polymerases α, β and γ, the inhibitory activity of raltegravir is weak.
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