Relief Ultra®
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Clinical Pharmacology
Regenerating, glucocorticoid, anti-inflammatory local.
Indications
- external and internal hemorrhoids;
- cracks and erosion of the anus;
- proctitis;
- anal itching, eczema and dermatitis of the perianal area.
Composition
In 1 candle: hydrocortisone 10 mg., Zinc sulfate 10 mg.
Excipients: methyl parahydroxybenzoate 0.4 mg (0.02%); propyl parahydroxybenzoate - 0.4 mg (0.02%); cocoa bean butter - 1974.2 mg (98.71%); anhydrous calcium phosphate - 2 mg (0.1%); magnesium stearate - 2 mg (0.1%)
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Dosage and Administration
The drug should be used after hygiene. Introduce into the rectum 1 suppository up to 4 times / day.
Adverse reactions
Possible: local allergic reactions (hyperemia, itching).
Contraindications
- bacterial, fungal and viral infections in the area of drug administration;
- neoplasms of the anorectal zone;
- tuberculosis;
- Itsenko-Cushing syndrome;
- severe forms of diabetes;
- hypernatremia;
- pregnancy;
- lactation period (breastfeeding);
- Hypersensitivity to the drug.
Pregnancy and Lactation
The drug is contraindicated during pregnancy and lactation (breastfeeding).
Special instructions
In severe hypertension, heart rhythm disturbances, immunodeficiency states, osteoporosis, diabetes mellitus and other endocrine pathologies, the use of the drug is permissible only according to strict medical indicators, if the expected therapeutic effect exceeds the potential risk of side effects or complications of the underlying disease.
Overdosage
Symptoms: hyperglycemia, hypernatremia, Itsenko-Cushing syndrome, immunosuppression, erosion and ulcers of the gastrointestinal tract, osteoporosis.
Treatment: drug withdrawal, conventional detoxification and symptomatic therapy.
- Brand name: Relief Ultra
- Active ingredient: Hydrocortisone Acetate, Zinc Sulphate Monohydrate
- Dosage form: Rectal suppositories from pale yellow to light yellow in color, opaque, in the form of a torpedo.
- Manufacturer: Bayer Pharma AG
- Country of Origin: Germany
Studies and clinical trials of Relief Ultra (Click to expand)
- Synthesis and Antiinfluenza Evaluation of Orally Active Bicyclic Ether Derivatives Related to Zanamivir.
- ChemInform Abstract: Synthetic Approaches to the Neuraminidase Inhibitors Zanamivir (Relenza) and Oseltamivir Phosphate (Tamiflu) for the Treatment of Influenza
- Electrochemical Studies of the Neuraminidase Inhibitor Zanamivir and its Voltammetric Determination in Spiked Urine
- Attaching zanamivir to a polymer markedly enhances its activity against drug-resistant strains of influenza a virus
- Development of a Sensitive Chemiluminescent Neuraminidase Assay for the Determination of Influenza Virus Susceptibility to Zanamivir
- Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo
- Interaction of zanamivir with DNA and RNA: Models for drug–DNA and drug–RNA bindings
- Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses
- Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir