Sennoside A and B
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2019-09-19
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Clinical Pharmacology
Today, a disturbance in the work of the digestive system is often accompanied by a delayed bowel movement, which is one of the most common problems of mankind. Sitting work, sedentary lifestyle, stress, unhealthy diet, increased fatigue and excessive nervous tension often provoke a delay in stool.
Senna is a widely used plant as a laxative, which causes increased motility of the large intestine.
Sennaplant-based senna-based natural laxative helps regulate stools.
How do the ingredients work?
Senna (cassia) has an antitoxic and laxative effect, due to the presence of antraglikozidov, which manifests itself after 6-8 hours after administration. Unlike other laxatives, cassia in therapeutic doses usually does not cause pain in the abdomen. Senna does not contain bitter and tannins, in consequence of which it does not increase the appetite and does not cause a delay in bowel movements after a laxative effect.
Composition
senna dry extract, pregelatinized starch (filler); microcrystalline cellulose and croscaramellose (carriers); talc, amorphous silicon dioxide, magnesium stearate of vegetable origin (anti-caking agents), peppermint oil.
Sennoside A and B is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Sennaplant | pills | ||
| Senade | Cipla Ltd | India | pills |
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Dosage and Administration
It is taken orally usually 1 time a day in the evening before bedtime, washed down with water or any drink.Adults and children over 12 years old: 1 tablet per dose. If there is no effect, the dose can be increased to 2-3 tablets.
Children 6-12 years old: 1/2 tablet and, if necessary, increase the dose to 1-2 tablets.
In the selection process, the same dose should be taken over several days and gradually increased by 1/2 tablet.
If, after reaching the maximum dose, there is no bowel movement within 3 days, a doctor should be consulted.
Adverse effects
From the digestive system:colicky abdominal pains, flatulence are possible; with prolonged use, especially in high doses, deposition of melanin in the intestinal mucosa, nausea, vomiting, diarrhea are possible.
From the side of metabolism:
with prolonged use, especially in high doses, violations of water-electrolyte metabolism, deposition of melanin in the intestinal mucosa are possible.
From the urinary system:
with prolonged use, especially in high doses, albuminuria, hematuria, discoloration of urine are possible.
From the side of the central nervous system:
with prolonged use, especially in high doses, convulsions, fatigue, confusion are possible.
Dermatological reactions:
with prolonged use, especially in high doses, skin rash is possible.
On the part of the cardiovascular system:
with prolonged use, especially in high doses, vascular collapse is possible.
- Brand name: Sennaplant
- Active ingredient: Sennoside A and B
- Manufacturer: Cipla Ltd
Studies and clinical trials of Sennoside A and B (Click to expand)
- An Efficient Total Synthesis of Chrysophanol and the Sennoside C Aglycon.
- Determination of sennoside A and B in the pharmaceutical preparation Otsuji-to using ion-pair high-performance liquid chromatography with column switching
- An efficient total synthesis of chrysophanol and the sennoside C aglycon
- Rapid and simple determination of sennoside A and B in rhei rhizoma by ion-pair high-performance liquid chromatography
- Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use?
- Development of eastern blotting technique for sennoside A and sennoside B using anti-sennoside A and anti-sennoside B monoclonal antibodies
- Effect of different soil types on plant growth, leaf pigments and sennoside content in Cassia species
- Seasonal variation in the content of sennoside in Senna leaves
- Voorschrift ter bereiding van sennoside laxeerdrank
- Bowel preparation for the total colonoscopy by 2,000 ml of balanced lavage solution (Golytely) and sennoside
- Simple and rapid analysis of sennoside A and sennoside B contained in crude drugs and crude drug products by solid-phase extraction and high-performance liquid chromatography
- Paper chromatographic separation of sennoside A and sennoside B
- A case of interstitial granulomatous drug reaction due to sennoside
- Erythema multiforme-like drug eruption caused by sennoside
- Acute generalized exanthematous pustulosis caused by sennoside in a patient with multiple myeloma
- Regionally Differential Effects of Sennoside A on Spontaneous Contractions of Colon in Mice
- Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1
- Usefulness of sennoside as an agent for mechanical bowel preparation prior to elective colon cancer surgery
- Enzyme-linked immunosorbent assay for total sennosides using anti-sennside A and anti-sennoside B monoclonal antibodies
- Laxative Effect of Sennoside A and Placebo in a Double-blind Cross-over Test
- The Effect of Different Storage Conditions on the Chemical Stability, Laxative Effect and Acute Toxicity of Sennoside Solutions
- Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells
- Sennoside content and yield attributes of Cassia angustifolia Vahl. as affected by NaCl and CaCl2
- Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract
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