Buy Histafin pills 50 mg, 20 pcs
  • Buy Histafin pills 50 mg, 20 pcs


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Clinical Pharmacology

Histamine N blocker1receptors with antiserotinin activity. Moderately blocks serotonin 5HT1-receptors, weakening the effect of mediators of histamine and serotonin allergy. Histamine causes clinical manifestations of allergic inflammation: edema (increased capillary permeability), skin flushing (dilation of blood vessels), itching and pain.

The specific feature of Sequifenadine is that it has an antihistamine effect not only by blocking histamine H1receptors, but also reducing the content of histamine in the tissues by accelerating its destruction by diamine oxidase.

Allergic diseases also increase the level of serotonin in the blood. Serotonin increases blood pressure, causes bronchospasm, increases capillary permeability, enhances the effect of inflammatory mediators - histamine, bradykinin, prostaglandins. Sequifenadine prevents or weakens the spasmogenic effect of histamine and serotonin on the smooth muscles of the bronchi, intestines, blood vessels; violation of capillary permeability and the development of edema.

Sequifenadine has a pronounced antipruritic and antiexudative effect of a prolonged nature.

Affects the immunological reactivity of the organism, reducing the number of B-lymphocytes in the spleen, bone marrow, lymph nodes, and also reduces the increased concentration of immunoglobulins of classes A and G.

Slightly penetrates through the BBB, which explains the absence of a pronounced inhibitory effect on the central nervous system, but in some cases, with individual hypersensitivity, a slight sedation is observed.

While taking Sequifenadine, no changes in the biochemical parameters of blood and urine are observed, the drug does not affect blood pressure, ECG indicators, glucose and cholesterol levels in the blood, does not affect the EEG indicators.


- allergic rhinitis;

- allergic conjunctivitis;

- pollinosis;

- urticaria;

- Quincke swelling;

- allergic pruritic dermatosis (including atopic dermatitis);

- prevention of diseases of an allergic nature to the period of their seasonal exacerbation and supportive therapy.


Excipients: lactose monohydrate - 302 mg, microcrystalline cellulose - 20 mg, corn starch - 20 mg, silicon dioxide - 2 mg, magnesium stearate - 6 mg.

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Dosage and Administration

The drug should be taken orally after a meal, drinking water.

Adults with acute and chronic allergic diseases prescribed 50-100 mg 2-3 times / day. Usually, the therapeutic effect occurs 3 days after the start of treatment. Duration of treatment is 5-15 days.

In order to prevent diseases of an allergic nature before the period of their seasonal exacerbation and for maintenance therapy, 50 mg is prescribed 2 times / day. The drug is recommended to start 2 weeks before the expected impact of the seasonal allergen.

Adverse reactions

On the part of the digestive system: dry mouth, pain in the epigastrium, dyspepsia, increased appetite.

From the side of the central nervous system: headache, drowsiness; when used in high doses, possible excitement, insomnia.

Other: rarely - leukopenia, menstrual irregularities, increased urination.


- bronchial asthma;

- pregnancy;

- lactation period (breastfeeding);

- children's and teenage age up to 18 years;

- simultaneous use of MAO inhibitors;

- hypersensitivity to the drug;

- the tablet contains lactose, so the drug should not be used with a deficiency of lactase, rare hereditary lactose intolerance or glucose-galactose malabsorption.

With caution should use the drug for violations of the kidneys, severe diseases of the cardiovascular system, gastrointestinal tract, liver.

Drug interactions

Sehifenadine does not enhance the inhibitory effect of hypnotic drugs and alcohol on the central nervous system, but during treatment it is necessary to refrain from drinking alcohol.

Pregnancy and Lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Special instructions

There are no clinical studies on the use of the drug in children and patients of senile (over 70 years) age.

Sehifenadine tablets can be combined with topical preparations (ointment, eye drops, nasal drops).

In most cases, drowsiness decreases or disappears after 2-5 days from the start of treatment.

Influence on ability to drive motor transport and control mechanisms

Patients whose work requires quick psychomotor reactions (including transport drivers) must refrain from driving and from engaging in potentially hazardous activities during the treatment period.


Symptoms: dry mucous membranes, headache, vomiting, abdominal pain.

Treatment: symptomatic therapy. The antidote is unknown.

  • Brand name: Histafin
  • Active ingredient: Sequifenadine
  • Dosage form: pills of white or almost white color, round, flat-cylindrical, with a facet and risky.
  • Manufacturer: Olainfarm
  • Country of Origin: Latvia

Studies and clinical trials of Sequifenadine (Click to expand)

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