Solcoseryl is a calf blood dialysate, that is used as a topical cream to promote wound healing
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SOLCOSERYL®, a hemodialysate of calf blood that contains low-molecular-weight blood components such as amino acids, oligopeptides, nucleosides, and glycolipids, was shown to offer a significant cytoprotection in cerebral hypoxic episodes. Specifically, the agent was shown to increase cerebral blood flow, inhibit the development of cytotoxic (6-aminonicotinamid-induced) brain edema, and antagonize the decrement of glucose utilization in limbic areas (cingulate cortex, amygdala, and septal nuclei), the basal ganglia, and the thalamus following stroke in stroke-prone spontaneously hypertensive rats.
Further, S appeared to reduce the formation of free radicals. It had a significant inhibitory effect on the activity of the archidonic cascade and the production of lipid peroxides. A similar preparation, Actovegin®, was reported to increase cerebral metabolism depressed by alcohol and barbiturates and reduce the detrimental effects of an ischemic episode to cortical neurons. Actually, in the hippocampus the ischemia-related reduction of adenosine triphosphate (ATP) and CrP is counterbalanced by Actovegin.
Solcoseryl also used in gel form as a topical wound-healing promoting agent.
Solcoseryl® is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Solcoseryl||Meda Pharma GmbH & Co. KG||Switzerland||ointment|
|Solcoseryl||Meda Pharma GmbH & Co. KG||Switzerland||gel|
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Dosage and Administration
Solcoseryl ointment is applied with a thin layer on the cleaned wound 1-2 times a day, can be applied under dressings. The course of treatment with Solcoseryl ointment continues until the wound is completely healed, its epithelialization and the formation of elastic scar tissue.
For the treatment of severe trophic lesions of the skin and soft tissues, the simultaneous use of parenteral forms of Solcoseryl is recommended.
In rare cases, allergic reactions may develop (urticaria, hyperemia and edema at the injection site, increased body temperature). In this case, it is necessary to discontinue the use of the drug and prescribe symptomatic treatment.
Hypersensitivity to one of the components of the drug.
Carefully - with a predisposition to allergic reactions.
Solcoseryl injections should not be mixed with the introduction of other drugs, especially with phytoextracts.
The pharmaceutical incompatibility of Solcoseryl in the form of a solution for injection with parenteral forms has been established:
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- Bentsiklana fumarata.
As solutions for dilution of Solcoseryl injection, only isotonic sodium chloride solution and 5% glucose solution should be used.
The interaction of Solcoseryl with other drugs of local action is not installed.
Pregnancy and Lactation
The use of Solcoseryl, like all other drugs, is undesirable during pregnancy and lactation and is possible only when absolutely necessary and under the supervision of a physician.
In the event of pain, redness of the skin near the site of application of Solcoseryl, the secretion of secretion from the wound, increase in body temperature, it is urgent to consult a doctor.
If during the application of Solcoseryl, the healing of the affected area is not observed within 2–3 weeks, it is necessary to consult a doctor.
- Brand name: Solcoseryl
- Active ingredient: Deproteinized dialysate from calf blood
- Dosage form: Ointment
- Manufacturer: Meda Pharma GmbH & Co. KG
- Country of Origin: Switzerland
Studies and clinical trials of Solcoseryl (Click to expand)
- Effect of solcoseryl on the survival of skin-grafts and the healing of donor sites in rats
- The effect of Solcoseryl on chosen parameters in patients intoxicated with heavy metals
- Solcoseryl, a tissue respiration stimulating agent, significantly enhances the effect of capacitively coupled electric field on the promotion of bone formation around dental implants
- Solcoseryl: Ulcerostatic effect and its possible mechanisms
- Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl
- Solcoseryl prevents inflammatory and hypoxic but not toxic liver damage in rodents
- Comparative Multiparametric Analysis of HeLa and RD Cell Culture Reactions to Solcoseryl
- Sensitization to solcoseryl and methylanisate (fragrance ingredient)
- Influence of “Solcoseryl” during culture on the sex-dependent repair of bovine demi-embryos
- The radioprotective effect of solcoseryl
- The Effect of He-Ne Laser (632.8 nm) and Solcoseryl™ In vitro
- Effect of nootropic Solcoseryl® on kainic acid-induced excitotoxic brain injury
- The Effectiveness of the Haemodialysate Solcoseryl® for Second-Intention Wound Healing in Horses and Ponies
- Effect of Solcoseryl® on the clinical course of experimental Escherichia coli-endotoxin mastitis
- Zur Bedeutung des Solcoseryl® bei Infertilität : 1. Mitteilung: Der Einfluß von Solcoseryl® auf die Spermatozoenmotilität in vitro
- Zur Bedeutung des Solcoseryl® bei Infertilität) — 2. Mitteilung: Die Wirkung von Solcoseryl® bei pathologischen Spermiogrammbefunden in vivo
- Histological Evaluation of Wound Healing in Horses Treated with the Protein-Free Hemodialysate Solcoseryl and its Hexosylceramide Fraction
- Effect of solcoseryl on cadaveric split-skin oxygen consumption during 4 °C storage and in frozen biopsies
- Effect of a hexosylceramide fraction of the hemodialysate solcoseryl on wound-healing angiogenesis
- A New Technique of Skin Transplantation and a Preliminary Evaluation of the Effects of Solcoseryl on Graft Acceptance
- Effect of solcoseryl on the atherosclerotic rabbit model in which the left carotid artery is cuffed
- Embryo viability and development after prostaglandin E2 (PGE2) addition to the semen and progesterone (P4), solcoseryl® and PGE2 to the transfer medium
- Solcoseryl treatment of day-7 bovine embryos invitro
- In vitro culture of nonmanipulated and gene-microinjected mouse zygotes in medium supplemented with solcoseryl®