Stimol® [Citrulline Malate]
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PHARMACOLOGICAL EFFECTS: anti-asthenia effect, and also contributes to liver detoxification.
Citrulline is an amino acid that participates in the ammonia neutralization cycle occurring in the liver, which is formed as a result of the breakdown of nitrogen-containing compounds. Urea is formed in the liver from ammonia. Citrulline is built into the urea cycle, increases the excretion of ammonium ions.
Malate is involved in the Krebs cycle and gluconeogenesis, reduces the concentration of lactate in the blood, helps to normalize the metabolism, activates non-specific protective factors of the body.
PHARMACOKINETICS: the drug is rapidly absorbed from the gastrointestinal tract, the peak plasma concentration is reached on average after 50 minutes. Quickly derived from plasma. After 6 hours, the plasma concentration is close to physiological. Since the active ingredient is involved in the processes of cellular metabolism, only small amounts of it are found in the urine.
used in the symptomatic treatment of functional asthenia: asthenic syndrome, fatigue, increased fatigue, during the period of recovery from illness.
1 sachet contains:
Citrulline malate 1.00 g
Natural orange flavoring sangria 0.10 g
Sodium hydroxide solution 30% 0.1886 g
Purified water to 10.00 ml
DESCRIPTION: colorless or yellowish liquid with an orange smell.
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Dosage and Administration
adults and elderly: 3.0 g (contents of 3 bags) per day. Children from 5 years: 2.0 g (contents of 2 bags) per day.
STIMOL® should be taken with meals, mixing the contents of the bag with about 100 ml of water, normal or sweetened. The course of taking the drug 10-12 days. Repeated courses are possible after a break (1-3 months) or on the recommendation of a doctor.
In some cases, at the beginning of treatment, transient pain in the stomach, allergic reactions may occur.
peptic ulcer in the acute stage, increased individual sensitivity to the drug, children less than 5 years old.
data on any drug interactions are missing.
Pregnancy and Lactation
use of STIMOL® during pregnancy or lactation is justified if the expected benefit outweighs the potential risk.
each bag contains about 30 mg of sodium. This should be taken into account for patients on a salt-free diet.
Since the drug contains no sugar, it can be taken by patients with diabetes.
Symptoms: gastrointestinal disturbances, nausea, vomiting, dizziness, and drowsiness; depression of consciousness of varying severity (in severe forms).
Treatment: gastric lavage and symptomatic therapy. Dialysis is ineffective.
Experience to date indicates that even extremely high doses (single intake of 375 mg) do not necessarily cause severe symptoms.
- Brand name: Stimol
- Active ingredient: Citrulline Malate
Studies and clinical trials of Citrulline Malate (Click to expand)
- Use of a microbial model for the determination of drug effects on cell metabolism and energetics: Study of citrulline-malate
- l-Citrulline-malate influence over branched chain amino acid utilization during exercise
- Effects of a first exposure to ethanol on the compositions of neutral and polar lipids in Euglena gracilis Z, taken as a hepatic cell model: Equilibration by citrulline-malate
- Citrulline-malate effect on microsome phospholipids and cytochrome P450 in Euglena grown with ethanol
- Beneficial effects of citrulline malate on skeletal muscle function in endotoxemic rat
- Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle
- Analyse par RMN du P-31 des effets du malate de citrulline sur le métabolisme énergétique musculaire chez l'homme
- Euglena, as a cellular model used in pharmacology for studying the effects of citrulline malate on lactate metabolization
- Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: A clinical trial
- Effect of citrulline-malate supplementation on plasma amino acids and glycemic and insulinemic responses in horses
- Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins
- Citrulline/malate promotes aerobic energy production in human exercising muscle
- Effects of Supplemental Citrulline-Malate Ingestion on Blood Lactate, Cardiovascular Dynamics, and Resistance Exercise Performance in Trained Males
- Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females
- Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players
- Effects of Supplemental Citrulline Malate Ingestion During Repeated Bouts of Lower-Body Exercise in Advanced Weightlifters
- Acute Citrulline-Malate supplementation and high-intensity cycling performance
- Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness
- Scientific Opinion on the substantiation of a health claim related to citrulline malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006
- Scientific Opinion on the substantiation of a health claim related to citrulline-malate and faster recovery from muscle fatigue after exercise pursuant to Article 13(5) of Regulation (EC) No 1924/2006
- The Effect of Citrulline/Malate on Blood Lactate Levels in Intensive Exercise
- Effect Of Acute Citrulline-malate Supplementation On Muscular Power
- The Effect of Citrulline Malate on Wingate Anaerobic Power Test Performance
- The Effect of Citrulline Malate Supplementation On Muscle Fatigue Among Healthy Participants