Sulfacetamide
1993 Items
2019-09-19
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Clinical Pharmacology
Antibacterial agent for local use in ophthalmology, sulfanilamide derivative. Possesses a wide range of antimicrobial action. It has a bacteriostatic effect. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.
Sulphacetamide is active against gram-positive and gram-negative bacteria (including pathogenic cocci, Escherichia coli), Chlamydia spp., Actinomyces spp.
Indications
Purulent corneal ulcers, conjunctivitis, blepharitis, gonorrheal eye diseases in newborns and adults, prevention of necrosis in newborns.
Composition
1 ml contains:
Active ingredient sulfacetamide 200 mg.
Auxiliary substances: sodium thiosulfate; hydrochloric acid solution 1 M; water for injections
Sulfacetamide is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Sodium sulfacyl | eye drops | ||
| sodium-SOLOpharm | Grotex Ltd | Russia | Other |
| sodium-SOLOpharm | Grotex Ltd | Russia | bottle |
| Sodium sulfacyl | PFK Obnovlenie | Russia | eye drops |
| Sulfacyl Sodium Belmedpreparaty | Belmedpreparaty | Belarus | eye drops |
| Sulfacyl sodium-DIA | Diapharm | Russia | eye drops |
| Sodium sulfacyl | Diapharm | Russia | eye drops |
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Dosage and Administration
The drug is instilled into the conjunctival sac, 1-2 drops of a solution (10-20 mg of sulfacetamide) 5-6 times a day, and a drop of a solution (10 mg of sulfacetamide) 3-6 times a day is instilled in children. To prevent blistering in newborns, 1 drop of solution (10 mg of sulfacetamide) is instilled into each eye three times with an interval of 10 minutes.
Adverse reactions
The use of the drug may cause local tissue irritation (short-term burning, redness, swelling, allergic reactions).
Contraindications
Increased individual sensitivity to sulfa drugs.
Drug interactions
Combined use with procaine and tetracaine reduces the bacteriostatic effect of sodium sulfacyl. There is an incompatibility of sodium sulfacyl in its combined use with silver salts.
Special instructions
Caution is prescribed to patients with allergic anamnesis.
Overdosage
Symptoms: tissue irritation (burning, redness, swelling, stinging, tearing).
Treatment: you should reduce the dose of the drug, increase the interval between the use of eye drops or cancel the drug.
- Brand name: Striks
- Active ingredient: Strontium ranelate
- Manufacturer: K.O.Romparm Company S.R.L.
- Country of Origin: Romania
Studies and clinical trials of Sulfacetamide (Click to expand)
- Pharmacokinetic study on the mechanism of interaction of sulfacetamide sodium with bovine serum albumin: a spectroscopic method
- Quantitative analysis of sodium sulfacetamide solutions in the presence of hydrolysis products, sulfanilamide and sodium acetate
- A column chromatographic method for the determination of sulfanilamide in pharmaceutical preparations containing sulfacetamide or its sodium salt
- Assay of sulfacetamide sodium ophthalmic solutions by high-pressure liquid chromatography
- Effects of preservatives, steroids, and ethylenediaminetetraacetate on the antimicrobial activity of sulfacetamide
- Solid-solid reaction between sulfacetamide and phthalic anhydride
- A phosphorimetric investigation of several sulfonamide drugs: a rapid direct procedure for the determination of drug levels in pooled human serum with specific application to sulfadiazine, sulfamethazine, sulfamerazine and sulfacetamide
- Quantitative determination of sulfanilamide in sodium sulfacetamide raw material and ophthalmic solutions by high-performance liquid chromatography
- Synthesis and spectroscopy studies of copper(II) nitrate of sulfacetamide drug. Crystal structure of [Cu(sulfacetamide)2(NO3)2]. Antibacterial studies
- Cobalt(II), Nickel(II), and Copper(II) complexes of sulfanilamide derivatives: Synthesis, spectroscopic studies, and antibacterial activity. Crystal structure of [Co(sulfacetamide)2(NCS)2]
- Evaluation of limiting molar conductance, Walden product, association constant and thermodynamic properties of sulfacetamide sodium in water + EtOH mixtures
- Investigation of radiosterilization and dosimetric features of sulfacetamide sodium
- Determination of prednisolone acetate, sulfacetamide and phenylefrine in local pharmaceutical preparations by micellar electrokinetic chromatography
- Crystal and molecular structure ofp-aminobenzene sulfonacetamide sodium [sulfacetamide sodium] monohydrate
- Depolymerization of hyaluronate by the phototoxic drugs phenothiazines and sulfacetamide
- SUCCESSFUL TREATMENT OF ACNE VULGARIS IN WOMEN WITH A NEW TOPICAL SODIUM SULFACETAMIDE/SULFUR LOTION
- Structure of sodium N-(p-aminobenzenesulfonyl)acetamide monohydrate (sodium sulfacetamide monohydrate)
- Structure of the silver salt of N-(p-aminophenylsulfonyl)acetamide (silver sulfacetamide)
- Structure cristalline du complexe 1:1 sulfacétamide–caféine
- Bioadhesive sulfacetamide sodium microspheres: Evaluation of their effectiveness in the treatment of bacterial keratitis caused by Staphylococcus aureus and Pseudomonas aeruginosa in a rabbit model
- A double-blind, comparative facial tolerance study of a new 10% sodium sulfacetamide & 5% sulfur aqueous gel (in a 10% urea vehicle) vs. a 10% sodium sulfacetamide & 5% sulfur topical suspension in rosacea & acne subjects with sensitive skin
- Patient acceptability of a new fragrance-free sulfacetamide/sulfur cleanser
- Dermal tolerability and safety of a fragrance-free sulfacetamide/sulfur cleanser
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