Sulfadiazine

Brand Tallinn Pharmaceutical Plant

In stock 734 Items

Available since: 2019-09-19

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Clinical Pharmacology

Sulfargin® is a broad-spectrum antimicrobial bactericidal agent belonging to the group of sulfonamides. The drug is active against gram-positive and gram-negative bacteria Escherichia coli, Proteus spp., Staphylococcus spp., Klebsiella spp.

The bactericidal properties of Sulfargin ointment are due to the activity of silver ions, which are released in the wound as a result of the dissociation of the silver sulfadiazine salt; the release of silver ions occurs gradually (moderate dissociation), ensuring the constancy of the antimicrobial effect. The bactericidal activity of silver ions is complemented by the bacteriostatic effect of sulfadiazine (also released during the dissociation of the silver salt of sulfadiazine).

Sulfargin is characterized by moderate osmotic activity and does not possess necrolytic properties.

When applied to the wound surface, about 10% sulfadiazine and 1% silver are absorbed into the peripheral and systemic circulation. Application to the extensive wound surface is accompanied by an increase in the concentration of sulfadiazine in the blood to 10-20 μg / ml.

Indications

Treatment of infected burn wounds, pressure sores, abrasions, skin ulcers, transplanted skin; and the prevention of their infection.

Wounds (including nonhealing), trophic ulcers, bedsores, burns with mild exudation.

Composition

1 g ointment contains:
active substance: silver sulfadiazine 10 mg;
Excipients: vaseline oil, propylene glycol, cetyl stearyl alcohol, glycerol monostearate 40-55, polysorbate 80, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water.

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Dosage and Administration

Outwardly. After surgical treatment of the wound and removal of necrotic tissue, a thin layer (2-4 mm) of ointment (under a bandage or open method) is applied to the damaged surface 1-2 times a day.
The maximum single dose is 300 g. The treatment period is individual and depends on the nature of the disease and the effectiveness of the treatment used, in general cases lasts up to 3 weeks.
Application of the ointment to the skin is painless, the ointment does not stain clothes and linen.
If you forget to use the drug, use it as soon as possible and continue using as usual Do not use a double dose if the previous time of drug administration was missed.
If you feel that the effect of the drug is too strong or weak, inform your doctor about it.

Adverse reactions

Burning and itching at the site of application, violation of skin pigmentation, skin allergic reactions, skin necrosis, erythema multiforme, interstitial nephritis, leukopenia, which is mainly characterized by a decrease in the number of neutrophils.
With prolonged use on large wound surfaces: systemic side effects characteristic of sulfonamide drugs, including impaired hematopoiesis (agranulocytosis, aplastic and hemolytic anemia, thrombocytopenia, leukopenia), skin and allergic reactions, including Stevens-Johnson syndrome and exfoliative dermatitis ; dyspepsia, hepatitis, hepatocellular necrosis, dysfunction of the central nervous system and toxic nephrosis.
The degree of absorption of the drug depends on the size of the burn surface and the degree of tissue damage.