Sulfadimethoxine
Biosynthesis
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Clinical Pharmacology
Antibacterial agent, sulfonamide derivative. Sulfadimethoxin has a long lasting effect when taken orally. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.
Indications
Infectious and inflammatory diseases caused by microorganisms susceptible to sulfadimethoxine, incl. angina, sinusitis, otitis media, bronchitis, dysentery, inflammatory diseases of the biliary and urinary tract, erysipelas, wound infections, trachoma.
Composition
1 tablet contains sulfadimetoksina 200 mg.
Sulfadimethoxine is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Sulfadimethoxine | Biosynthesis | Russia | pills |
| Sulfadimethoxine | Pharmstandard | Russia | pills |
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Dosage and Administration
Sulfadimethoxine Administered orally. Accept every 24 h: in the 1st day - 1-2 g, in the subsequent - 0.5-1 g / day; children - 25 mg / kg / day on the first day and 12.5 mg / kg / day - in the next.
Adverse reactions
From the side of the central nervous system: possible headache.
From the digestive system: dyspeptic symptoms, nausea, vomiting, cholestatic hepatitis.
Allergic reactions: skin rash, drug fever.
From the hemopoietic system: rarely - leukopenia, agranulocytosis.
Contraindications
Hypersensitivity to sulfonamides, inhibition of bone marrow hematopoiesis, renal and / or liver failure, chronic heart failure, congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy.
Drug interactions
Sulfadimethoxine reduces the effectiveness of bactericidal antibiotics that act only on fissile microorganisms (including penicillins, cephalosporins).
Pregnancy and Lactation
Sulfadimethoxine is contraindicated for use in pregnancy.
Special instructions
During treatment it is recommended to drink plenty of alkaline drinks, monitor blood and urine parameters.
It is used externally as part of combined preparations.
- Brand name: Sulfadimethoxine
- Active ingredient: Sulfadimethoxine
- Dosage form: Pills.
- Manufacturer: Biosynthesis
- Country of Origin: Russia
Studies and clinical trials of Sulfadimethoxine (Click to expand)
- Crystal and Molecular Structure of Sulfadimethoxine, Polymorph III
- Biological implications of molecular and crystal structures of sulfadimethoxine, sulfadoxine, and sulfisoxazole
- Kinetics of drug-drug interactions in sheep: Tolbutamide and sulfadimethoxine
- Effect of sulfadimethoxine on thiopental distribution and elimination in rats
- Disposition of sulfadimethoxine in cattle: Inclusion of protein binding factors in a pharmacokinetic model
- Binding of sulfadimethoxine to isolated human blood protein fractions
- A New Polymeric pH Sensor Based on Photophysical Property of Gold Nanoparticle and pH Sensitivity of Poly(sulfadimethoxine methacrylate)
- pH-Sensitivity and pH-dependent structural change in polymeric nanoparticles of poly(vinyl sulfadimethoxine)–deoxycholic acid conjugate
- Restricted-access media liquid chromatography for determination of sulfamonomethoxine, sulfadimethoxine, and their N4-acetyl metabolites in eggs
- Role of a novel multifunctional excipient poly(ethylene glycol)-block-oligo(vinyl sulfadimethoxine) in controlled release of lysozyme from PLGA microspheres
- Determination of sulfadimethoxine, sulfamethoxazole, trimethoprim and their main metabolites in porcine plasma by column switching HPLC
- Application of shielded column liquid chromatography for determination of sulfamonomethoxine, sulfadimethoxine, and their N4-acetyl metabolites in milk
- Organic solvents-free technique for determining sulfadimethoxine and its metabolites in chicken meat
- Determination of sulfadimethoxine and 4N-acetylsulfadimethoxine in bovine plasma, urine, oral fluid, and kidney and liver biopsy samples obtained surgically from standing animals by LC/MS/MS
- Simultaneous determination of sulfamethoxypyridazine, sulfamethoxazole, sulfadimethoxine and their associated compounds by liquid chromatography
- Rapid high-performance liquid chromatographic determining technique of sulfamonomethoxine, sulfadimethoxine, and sulfaquinoxaline in eggs without use of organic solvents
- Characterization of a Cu(II) complex of sulfadimethoxine
- Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops × Morone saxitalis)
- The biotransformation of sulfadimethoxine, sulfadimidine, sulfamethoxazole, trimethoprim and aditoprim by primary cultures of pig hepatocytes
- Fatal necrotizing angiitis after sulfadimethoxine therapy presenting as anaphylactoid purpura
- Pharmacokinetics, N1-glucuronidation and N4-acetylation of sulfadimethoxine in man
- pH- and temperature-sensitive bifunctional hydrogels ofN-isopropylacrylamide and sulfadimethoxine monomer
- Involvement of PTEN/Akt signaling in capsular invasive carcinomas developed in a rat two-stage thyroid carcinogenesis model after promotion with sulfadimethoxine
- Submerged Arc Breakdown of Sulfadimethoxine (SDM) in Aqueous Solutions
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