Sulfaguanidine
Irbit HFZ
1507 Items
2019-09-19
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Clinical Pharmacology
Sulgin - broad-spectrum antibacterial agent, sulfanilamide derivative. Sulfaguanidine is active against gram-positive and gram-negative microorganisms (including causative agents of intestinal infections). Poorly absorbed from the gastrointestinal tract.
Acts predominantly in the intestinal lumen. The mechanism of action of Sulgin is due to competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.
Indications
- Bacterial dysentery.
- Colitis and enterocolitis with diarrhea.
- Carriage of dysenteric sticks, typhoid sticks.
- Preparation for operations on the small and large intestine.
Composition
1 tablet contains sulfaguanidine 500 mg.
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Dosage and Administration
In acute dysentery, 2 treatments are performed.
The first course: 1 and 2 days - 1 g every 4 hours (only 6 g / day), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours ( 3 g / day).
If necessary, a second course is carried out in 5-6 days: 1 and 2 days - 1 g every 4 hours, at night - 8 hours (5 g / day in total), 3 and 4 days - 1 g after 4 hours (4 g / day), do not give at night, 5 day - 3 g / day. Children over 3 years old - 0.5 g 4 times a day for 7 days.
In the treatment of other infections: adults - inside, 1-2 g every 4-6 hours; in the next 2-3 days - half the dose. Children over 3 years old - on the first day at 0.1 g / kg / day in equal doses every 4 hours, on the following days - at 0.25-0.5 g every 6-8 hours.
For the prevention of postoperative intestinal complications - by 0.05 g / kg every 8 hours, within 5 days before and 7 days after surgery.
Higher doses for adults: single - 2 g, daily - 7 g.
Adverse reactions
From the digestive system: nausea, vomiting.
From the urinary system: crystalluria.
Allergic reactions: urticaria, exfoliative dermatitis.
Other: hypovitaminosis B, leukopenia, neuritis.
Contraindications
- Hypersensitivity to the drug or other sulfonamides;
- deficiency of glucose-6-phosphate dehydrogenase;
- nephrourolithiasis;
- porphyria;
- AT12deficiency anemia;
- pregnancy and lactation;
- children up to 3 years;
- hyperbilirubinemia (in children).
Drug interactions
Reduces the reliability of oral contraception.
Benzocaine, procaine reduce antimicrobial activity (PABA is released during hydrolysis).
Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and indirect anticoagulants increase the severity of side effects of the drug.
Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria.
Myelotoxic drugs increase the hematotoxicity of the drug.
Pregnancy and Lactation
Contraindicated in pregnancy and lactation.
Special instructions
In order to prevent crystalluria during the treatment period, patients should receive abundant drinking (2-3 l / day). Early cessation of treatment or insufficient doses can lead to the emergence of resistant strains of pathogens. During treatment, it is recommended to take vitamins of group B.
Overdosage
No information on overdose is available.
- Brand name: Sulgin
- Active ingredient: Sulfaguanidine
- Dosage form: Pills.
- Manufacturer: Irbit HFZ
- Country of Origin: Russia
Studies and clinical trials of Sulfaguanidine (Click to expand)
- Physical stability of sulfaguanidine suspensions
- Etude des transformations polymorphiques de la sulfaguanidine au cours de la compression
- Preparation, characterization and biological activity of Fe(III), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and UO2(II) complexes of new cyclodiphosph(V)azane of sulfaguanidine
- Erythema multiforme from sulfaguanidine
- Crystal structures of inclusion compounds of 4-aminobenzenesulfamidine (sulfaguanidine) with two dicyclohexano-18-crown-6 isomers
- Use of domestic membrane filters for the determination of microbial contamination of noninjection drugs such as sulfaguanidine
- Kinetics and mechanism of oxidation of sulfaguanidine by peroxydisulfate ion
- Influence of sulfaguanidine on certain symptoms of vitamin E deficiency in rats
- The use of sulfaguanidine in non-specific ulcerative colitis and other infections of the bowel
- The use of sulfaguanidine for ulcerative colitis
- Sulfadimethoxine and sulfaguanidine: Their sorption potential on natural soils
- Synthesis and performance of flame retardant additives based on cyclodiphosph(V)azane of sulfaguanidine,1,3-di-[N/-2-pyrimidinylsulfanilamide]-2, 2, 2.4, 4, 4-hexachlorocyclodiphosph(V)azane and 1,3-di-[N/-2-pyrimidinylsulfanilamide]-2, 4-di[aminoacetic acid]-2, 4-dichlorocyclodiphosph(V)azane incorporated into polyurethane varnish
- Comparison of the dimensions and conformation of the sulfaguanidine moiety in sulfaguanidine monohydrate and trans-dichlorobis(sulfaguanidine)palladium(II)
- Conformational characteristics of anhydrous sulfaguanidine: computer retrieval and analysis of N-substituted arylsulfonamides
- Absorption, Excretion, Acetylation and Distribution of Sulfaguanidine in Man
- SULFAGUANIDINE, SUCCINYLSULFATHIAZOLE, AND DEFICIENCY DISEASE
- Quality control of the powder pharmaceutical samples of sulfaguanidine by using NIR reflectance spectrometry and temperature-constrained cascade correlation networks
- Specific inhibition of cholesterol absorption by sulfaguanidine
- The structure of the solid crystalline palladium sulfaguanidine complex
- The use of sulfaguanidine as an intestinal antiseptic
- The chemotherapy of infantile diarrhea: A comparison of sulfathiazole and sulfaguanidine
- Shigella paradysenteriae infection in mice: Treatment with sulfaguanidine and sulfacetimide (sulamyd)
- The use of sulfaguanidine in enteric infections
- Susceptibility of Shigella paradysenteriae tosodium sulfathiazole and sulfaguanidine in vitro: With some information regarding eberthella typhosa,salmonella paratyphosa, escherichia coli, salmonella morgani and proteus
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