Suprastin® [Chloropyramine]

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Available since: 2019-09-19

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Clinical Pharmacology

Suprastin is a blocker of histamine H1 receptors, a derivative of ethylene diamine. Prevents the development and facilitates the course of allergic reactions. It has a moderate sedative and pronounced antipruritic effect. It has peripheral anticholinergic activity, moderate antispasmodic properties.

Suggested use

Adults appoint 25 mg (1 tab.) 3-4 times a day (75-100 mg / day). Children aged 1-12 months appoint 1/4 tab. (6.25 mg) 2-3 times a day (in the form of pounded to powder, together with baby food); 2-6 years - 1/3 tab. (8.3 mg) 2-3 times a day; 7-14 years- 1/2 tab. (12.5 mg) 3 times a day. pills should be taken after meals.

Indications

Allergic diseases (including urticaria, serum sickness, pollinosis, or hay fever, rhinitis, conjunctivitis); anaphylactic shock and angioedema; skin diseases (including contact dermatitis, acute and chronic eczema, neurodermatitis, toxicoderma); prevention and treatment of allergic and pseudo-allergic reactions to the use of drugs and diagnostic products; itching and insect bites; SARS.

Composition

1 tablet contains chloropyramine hydrochloride 25 mg; excipients: lactose, starch, talc, sodium amylopectin, gelatin, stearic acid.

Chloropyramine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Suprastin	Egis	Hungary	pills
Chloropyramine	Sotex	Russia	ampoules
Suprastin	Egis	Hungary	solution

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Adverse reactions

From the side of the central nervous system: possible lethargy, drowsiness, weakness, mild tremor, dizziness. Children may have some stimulating effect on the central nervous system, manifested by anxiety, increased irritability, insomnia. On the part of the digestive system: possible dry mouth, nausea, vomiting, diarrhea or constipation. Since the cardiovascular system: rarely - lowering blood pressure (more often in elderly patients), tachycardia, arrhythmia. Allergic reactions: possible skin rash, itching. Other: rarely - difficult urination.

Contraindications

hypersensitivity to the drug; acute attack of bronchial asthma; children's age up to 3 years (for this dosage form); lactase deficiency, lactose intolerance, glucose / galactose malabsorption (because the tablet contains 116 mg of lactose monohydrate); pregnancy; lactation period. With care: angle-closure glaucoma; urinary retention; prostatic hyperplasia; abnormal liver and / or kidney function; cardiovascular diseases; elderly patients.

Drug interactions

With simultaneous use Suprastin enhances the effects of anesthetics, hypnotics, tranquilizers, analgesics, MAO inhibitors, tricyclic antidepressants, atropine and sympatholytics. With simultaneous use of Suprastin and caffeine or phenamine, a decrease or elimination of the suppressive action of Suprastin on the CNS is noted.

Special instructions

The drug should be used with caution in elderly patients, with a lack of liver function and / or heart disease. With extreme caution should be prescribed the drug inside with angle-closure glaucoma, in patients with urinary retention and prostatic hypertrophy. When taken at night, the drug may increase the symptoms of reflux esophagitis. With caution, suprastin should be prescribed simultaneously with sedatives, tranquilizers, analgesics, MAO inhibitors, tricyclic antidepressants, atropine and / or sympatholytics. During treatment, you should exclude the use of alcoholic beverages. Influence on ability to drive motor transport and control mechanisms In the initial, individually determined period of Suprastin use, driving of vehicles and engaging in other potentially hazardous activities requiring psychomotor speed is not allowed. In the course of further treatment, the degree of restriction is determined depending on the individual tolerance of the drug.

Overdosage

Symptoms similar to the symptoms of atropine intoxication may appear. Treatment: There are no specific antidotes, therefore symptomatic treatment is carried out. In the period up to 12 hours after taking the drug Suprastin, gastric lavage is necessary (it should be noted that the anticholinergic effect of the drug prevents gastric emptying). The use of Activated charcoal is also shown. Monitoring of blood pressure and respiration is required.