Tamsulosin, Finasteride set

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Tamsulosin, Finasteride set

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A drugSonirid Duo contains tamsulosin 400 mcg in modified release capsules and finasteride 5 mg in film-coated pills.

Preparations are intended for daily use.

Daily doseSonirid Duo includes 1 capsule with a modified release of tamsulosin 400 μg and 1 tablet, film-coated, finasteride 5 mg.

Tamsulosin 400 mcg, modified release capsules, must be taken at the same time of day, after meals. Capsules should be swallowed whole, do not crush or chew, because this can disrupt the sustained release of the active ingredient.

For a full therapeutic effect, long-term use of the drug is necessary.Sonirid Duo.

If adverse reactions occur, you can transfer the patient to monotherapy with finasteride; however, it is recommended to return to the combined mode with increased severity of symptoms of BPH.

Adverse reactions

Adverse reactions with tamsulosin monotherapy

From the nervous system: frequent - dizziness; infrequent - headache; rare - fainting.

Since the cardiovascular system: infrequent - postural hypotension, tachycardia.

On the part of the respiratory system: infrequent - rhinitis.

From the digestive system: infrequent - constipation, diarrhea, nausea, vomiting.

On the part of the skin and subcutaneous fat: infrequent - rash, pruritus, urticaria; rare - angioedema.

From the reproductive system: infrequent - retrograde ejaculation; rare - priapism.

Adverse Reactions Monotherapy with Finasteride

On the part of the immune system: infrequent - hypersensitivity.

On the part of the organ of vision: infrequent - clouding of the lens.

From the digestive system:frequent - pain in the abdomen.

On the part of the skin and subcutaneous fat:infrequent - rash.

From the reproductive system and mammary glands:frequent - erectile dysfunction, impaired ejaculation, decreased ejaculate volume, decreased libido; infrequent - breast tenderness, increase in mammary glands, pain in the testicles.

During post-marketing follow-up, the following additional undesirable reactions are described (data on the frequency of unwanted reactions are not): hypersensitivity reactions, including pruritus, urticaria, swelling of the lips and face.

Adverse reactions combined treatment

In patients receiving combined treatment (finasteride and α₁adrenergic blocker) describes the same undesirable reactions that occur with the same frequency as with monotherapy with finasteride and α₁-blocker. However, the following exceptions were identified: erectile dysfunction and impaired ejaculation were more common with combined treatment, while disease progression (including increased symptoms of BPH or the need for surgical treatment) were more common with monotherapy.

Contraindications

WITHcaution: if there is a risk of obstructive uropathy; with liver diseases; when planning surgical treatment of cataracts.

Drug interactions

In in vitro studies of hepatic microsomal fractions (model of drug metabolism by the cytochrome P450 enzyme system), it was determined that tamsulosin does not enter into a pharmacokinetic interaction with finasteride during metabolism in the liver.

Additional tamsulosin interaction with other drugs and other types of interaction

No interaction was detected with the simultaneous use of tamsulosin and atenolol, enalapril, nifedipine or theophylline.

Combined use with cimetidine can cause an increase in plasma tamsulosin concentration, while furosemide causes its decrease. However, changing the dose of the drug is not required, because tamsulosin concentration remains in the normal range.

In vitro, diazepam, propranolol, trichloromethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not change the content of the free fraction of tamsulosin in human plasma.

Also tamsulosin does not change the content of the free fraction of diazepam, propranolol, trichloromethiazide and chlormadinone.

In in vitro studies of hepatic microsomal fractions (model of drug metabolism by cytochrome P450 enzyme system), no interaction with amitriptyline, salbutamol, glibenclamide and finasteride was observed at the level of hepatic metabolism.

However, diclofenac and warfarin may increase the rate of elimination of tamsulosin.

Theoretically, there is a possibility that concomitant use with tamsulosin may enhance the antihypertensive effect of other drugs, such as general anesthesia or other drugs.₁-blockers.

Additional interactions with finasteride with other drugs and other types of interactions

No clinically significant interaction was found with the combined use of finasteride with the following drugs: warfarin, ACE inhibitors, α₁-adrenoblockers, theophylline, acetylsalicylic acid, paracetamol, beta-blockers, diuretics, nitrates, slow calcium channel blockers, anticonvulsants, NSAIDs, benzodiazepines, quinolones, histamine H blockers₂-receptors, 3-hydroxy-3-methyl-glutaryl-coenzyme A-reductase inhibitors (HMG-CoA).