Tantum® [Benzydamine]

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Available since: 2019-09-19

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Clinical Pharmacology

Local anesthetic, anti-inflammatory local.

Indications

Symptomatic therapy of pain syndrome of inflammatory diseases of the oral cavity and ENT organs (of various etiologies):

gingivitis, glossitis, stomatitis (including after radiation and chemotherapy);
pharyngitis, laryngitis, tonsillitis;
candidiasis of the oral mucosa (in combination therapy);
calculous inflammation of the salivary glands;
condition after surgery and injuries (tonsillectomy, jaw fractures);
condition after treatment and removal of teeth;
periodontal disease.

In infectious and inflammatory diseases that require systemic treatment, Tantum® Verde should be used as part of a combination therapy.

Composition

Active ingredient: benzydamine hydrochloride 3 mg.
Excipients: isomaltose - 3183 mg; levomenthol - 4 mg; aspartame, 3.5 mg; citric acid monohydrate - 2 mg; Mint flavor - 5 mg; lemon flavor - 1.5 mg; quinoline yellow dye (E104) - 0.035 mg; indigo carmine dye (Е132) - 0,015 mg.

Benzydamine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Tantum			lozenges
Tantum	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	lozenges
Tantum Rosa	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	powder
Tantum Rosa	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	solution
Tantum	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	solution
Tantum Verde	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	spray
Anhidak			spray
Tantum	Aziende Kimike Riunite Angelini Francesco A.K.R.A	Italy	spray

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Dosage and Administration

Locally, after meals. To hold pills in a mouth before full dissolution, not to swallow, not to chew.
The duration of treatment should not exceed 7 days. If after treatment within 7 days of improvement does not occur or new symptoms appear, you should consult with your doctor.
Use the drug should only according to the method of application and in those doses that are listed in the description. If necessary, you should consult with your doctor before using the drug.
Adults (including elderly patients) and children over 6 years old: 1 tabl. for sucking 3 times a day. Do not exceed the recommended dose. In children from 6 to 12 years old, the use of the drug is made under the supervision of an adult.

Adverse reactions

Classification of the incidence of side effects WHO: very often - ≥1 / 10; often from ≥1 / 100 to <1/10; infrequently - from ≥1 / 1000 to <1/100; rarely from ≥1 / 10000 to <1/1000; very rarely - <1/10000; frequency unknown - cannot be estimated based on available data.
In each group, unwanted effects are presented in order of decreasing severity.
Local reactions: rarely - dry mouth, burning in the mouth; frequency unknown - feeling numb in the mouth.
Allergic reactions: infrequently - photosensitivity; rarely, hypersensitivity reactions, skin rash, pruritus; very rarely - angioedema, laryngospasm; frequency unknown - anaphylactic reaction.
If any of the side effects indicated in the description are aggravated or any other side effects that are not mentioned in the description are noted, you should immediately inform your doctor.

Contraindications

Hypersensitivity to benzydamine or other components of the drug;
fructose intolerance;
children's age up to 6 years.

With care: hypersensitivity to acetylsalicylic acid or other NSAIDs; bronchial asthma (including in history).

Special instructions

At use of the drug Tantum® Verde development of reactions of hypersensitivity is possible. In this case, it is recommended to discontinue treatment and consult a doctor for the appointment of appropriate therapy. In a limited number of patients, the presence of ulcers in the throat and oral cavity may indicate the presence of a more serious pathology. If the symptoms persist for more than 3 days, you should consult with your doctor.
The use of the drug Tantum® Verde is not recommended in patients with hypersensitivity to acetylsalicylic acid or other NSAIDs.
Tantum® Verde should be used with caution in patients with a history of bronchial asthma because they may develop bronchospasm while taking the drug.
The drug contains isomaltose, and therefore is not recommended for patients with hereditary fructose intolerance.
Use of the drug in children is possible only under the supervision of adults in order to avoid swallowing the pill.
Influence on ability to steer vehicles, mechanisms.
Does not affect.

Overdosage

Currently, cases of overdose of Tantum® Verde have not been reported.
Symptoms: when using the drug in accordance with the description of overdose is unlikely. If the drug is swallowed accidentally, vomiting, abdominal cramps, anxiety, fear, hallucinations, convulsions, ataxia, fever, tachycardia, respiratory depression are possible.
Treatment: symptomatic; induction of vomiting or gastric lavage using a gastric tube (under medical supervision); provide medical observation, maintenance therapy and necessary hydration. The antidote is unknown.