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Tempalgin - analgesic antipyretic combined composition.
It has analgesic, antipyretic, mild anti-inflammatory and sedative effect.
The preparation includes non-opioid analgesic metamizole sodium and anxiolytic (tranquilizer) tempidone.
- moderately or mild pain syndrome (including headache, migraine, toothache, neuralgia, radicular syndrome, myalgia, arthralgia, algomenorrhea), especially in patients with increased nervous excitability;
- mild pain of visceral origin (including renal, hepatic, intestinal colic) in combination with antispasmodic therapy;
- pain syndrome after surgical and diagnostic interventions (as an aid);
- increase in body temperature in colds and other infectious and inflammatory diseases.
1 coated tablet contains:
Active substances: metamizole sodium 500 mg; Triacetonamine 4-toluenesulfonate (tempidone) 20 mg.
Excipients: wheat starch, microcrystalline cellulose, talc, magnesium stearate, crospovidone (collidon K25), titanium dioxide, polyethylene glycol 400, castor oil, glycerol, dibutyl phthalate, eudragit L acetone 12.5, green dye.
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Dosage and Administration
Orally, after eating, drinking water.
The dose depends on the severity of pain and individual sensitivity to the drug.
Adults: the usual dose - 1 tab. 1-3 times a day. The maximum single dose should not exceed 1 table. The maximum daily dose of 4 pills.
During dental procedures: 1 tab. 30 minutes before the intervention.
Children over 15 years: 1 tab. in a day. The maximum daily dose - 2 pills.
Special patient groups
Patients over 65 years old. Usually, no dose reduction is required. In patients with age-related disorders of the kidneys and liver, Tempalgin treatment should be short-lived. The maximum daily dose - 2 pills.
Liver dysfunction. In patients with impaired liver function may increase1/2 Metamizole sodium metabolites. In patients with moderate or severe liver damage, treatment is recommended 1/2 of the recommended dose for adults (maximum daily dose - 2 tab.).
Impaired renal function. Metamizole sodium and its metabolites are excreted by the kidneys. In patients with impaired renal function, treatment with Tempalgin® should be carried out using 1/2 of the recommended dose for adults (maximum daily dose - 2 tab.).
Duration of treatment
Tempalgin drug treatment® should not last more than 3-5 days. Its use over a longer period of time or at higher doses is possible only after consulting a doctor.
- epigastric burning sensation,
- dry mouth
- t rise
Carefullyprescribed for diseases of the kidneys (pyelonephritis, glomerulonephritis, including a history), hepatic / renal failure of moderate severity, with bronchial asthma, susceptibility to the development of arterial hypotension, with prolonged alcohol abuse.
Tempalgin enhances the effects of ethanol.
The simultaneous use of Tempalgin with chlorpromazine or other phenothiazine derivatives may lead to the development of severe hyperthermia.
Sedatives and tranquilizers enhance the analgesic effect of the drug.
With the simultaneous use of tiamazol and cytostatics increase the risk of leukopenia.
With simultaneous use of metamizole sodium with cyclosporine, the concentration of the latter in plasma decreases.
Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin from the connection with protein, increases their effect.
With the simultaneous use of barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the action of metamizole sodium.
The simultaneous use of metamizole sodium with other non-opioid analgesics, tricyclic antidepressants, oral contraceptives, allopurinol can lead to mutual enhancement of toxic effects.
Codeine, histamine H blockers2 -receptors and propranolol slow down the elimination of metamizole sodium and increase its effect.
Pregnancy and Lactation
The drug is contraindicated for use in pregnancy.
Do not use the drug during lactation, because both components are excreted in breast milk.
Radiocontrast drugs, colloid blood substitutes and penicillin should not be prescribed with Metamizole sodium.
Alcohol should not be taken while taking the drug.
The use of the drug in patients receiving cytostatics should be carried out only under the supervision of a physician.
Against the background of the use of metamizole sodium, agranulocytosis may develop, therefore, when detecting an unclear genesis of fever, chills, sore throat, difficulty swallowing, stomatitis, as well as the development of symptoms of vaginitis or proctitis, the drug should be canceled.
With prolonged (more than 7 days) taking the drug, it is necessary to control the blood picture and the functional state of the liver.
Tempalgin should not be used to relieve acute abdominal pain (until the cause is clarified).
Application for violations of the liver
Contraindicated in marked disorders of the liver.
Application for violations of renal function
Contraindicated in severe renal impairment.
Impact on the ability to drive vehicles and other mechanisms that require high concentration of attention
In connection with the anxiolytic effect of the drug during the period of taking Tempalgin, one should refrain from practicing potentially hazardous activities requiring increased attention and quickness of psychomotor reactions.
Symptoms: nausea, vomiting, epigastric pain, oliguria, tachycardia, decreased blood pressure, shortness of breath, tinnitus, drowsiness, impaired consciousness, convulsions.
Treatment: gastric lavage, the appointment of saline laxatives and Activated charcoal; in severe cases - hemodialysis, forced diuresis, symptomatic therapy, with the development of convulsive syndrome - IV the introduction of diazepam and high-speed barbiturates.
- Brand name: Tempalgin
- Active ingredient: Metamizole Sodium, Triacetonamine-4-toluenesulfonate
- Dosage form: pills, coated.
- Manufacturer: Sopharma
- Country of Origin: Bulgaria