Tenoxikam
E.I.P.I.Ko EG
1984 Items
2019-09-19
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Clinical Pharmacology
Tenoxicam, which is a thienothiazine derivative of oxicam, is an NSAID. In addition to anti-inflammatory, analgesic and antipyretic effects, the drug also prevents platelet aggregation. Tenoxicam exerts its anti-inflammatory effect by suppressing the activity of COX isoenzymes involved in the metabolism of arachidonic acid, and thus inhibits the synthesis of PG. Tenoxicam does not affect the activity of lipoxygenases. In addition, tenoxicam suppresses several leukocyte functions, including phagocytosis, histamine release and reduces the content of active radicals in the inflammatory focus.
Indications
- rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, articular syndrome with exacerbation of gout, bursitis, tendovaginitis;
- pain syndrome (weak and moderate intensity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algomenorrhea;
- pain with injuries, burns;
- inflammatory and degenerative diseases of the musculoskeletal system, accompanied by pain, such as sciatica, lumbago, epicondylitis.
- It is intended for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.
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Dosage and Administration
Inside, after meals (preferably at the same time), 20 mg (1 tab.) 1 time per day, with prolonged use - 10 mg per day.
In acute attacks of gout, 40 mg / day for the first 2 days, then 20 mg / day for 5 days.
Elderly patients are prescribed at a dose of 20 mg / day.
In acute attacks of gout, 40 mg / day for the first 2 days, then 20 mg / day for 5 days.
Elderly patients are prescribed at a dose of 20 mg / day.
Adverse reactions
The following adverse events were observed during treatment with Texared with the following frequency: very often (≥1 / 10); often (≥1 / 100 - <1/10); infrequently (≥1 / 1000 - <1/100); rarely (≥1 / 10000 - <1/1000); very rare (<1/10000), frequency unknown (frequency cannot be determined from available data).The undesirable phenomena that can be observed against the background of the use of the drug Texared in coated tablets include the following.
From the digestive system: infrequently - burning sensation in the stomach, stomach pain, vomiting, nausea, diarrhea, constipation, flatulence and gastropathy, abdominal pain, stomatitis, anorexia, liver dysfunction. With prolonged use in high doses - ulceration of the gastrointestinal tract mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), perforation of the intestinal walls.
From the CVS: infrequently - heart failure, tachycardia, increased blood pressure.
Allergic reactions: rarely - rash, itching, erythema and urticaria, photodermatitis.
From the nervous system: rarely - headache, dizziness, drowsiness, depression, agitation, hearing loss, tinnitus, eye irritation, visual impairment.
From the genitourinary system: rarely - an increase in the content of urea nitrogen and creatinine in the blood.
From the side of hematopoiesis: rarely - agranulocytosis, leukopenia, anemia, thrombocytopenia.
From the hepatobiliary system: rarely - an increase in the activity of ALT, AST and GGT and the level of bilirubin in serum.
Laboratory indicators: rarely - hypercreatininemia, hyperbilirubinemia, increased urea nitrogen concentration and hepatic transaminase activity, prolonged bleeding time.
During treatment, mental and metabolic disorders may occur.
Very rarely - Stevens-Johnson syndrome, Lyell's syndrome.
The undesirable phenomena observed on the part of the hematopoietic system include a decrease in the level of Hb and granulocytopenia.
Drug interactions
Reduces the effectiveness of uricosuric drugs, antihypertensive drugs and diuretics; enhances the effect of anticoagulants, antiplatelet agents, fibrinolytics, side effects of the adrenal cortex hormone, corticosteroids and estrogens; reduces the effectiveness; enhances the hypoglycemic effect of sulfonylurea derivatives. Increases blood concentration of lithium preparations, methotrexate. Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites. Antacids and cholestyramine reduce absorption. Other NSAIDs - the risk of side effects, especially from the gastrointestinal tract. Myelotoxic drugs increase the manifestations of the drug's hematotoxicity.Special instructions
During treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys, the prothrombin index (against the background of indirect anticoagulants), the concentration of glucose in the blood (against the background of oral hypoglycemic drugs). If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. A few days before surgery, the drug is canceled. It is necessary to take into account the possibility of sodium and water retention in the body when administered with diuretics to patients with arterial hypertension and CHF. To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used in the smallest possible short course. Influence on the ability to drive vehicles and control mechanisms. One of the undesirable effects of the drug is dizziness, this should be taken into account in situations that require the patient's close attention, for example, when driving a vehicle or complex technical devices. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
- Brand name: Artoxan
- Active ingredient: Tenoxikam
- Manufacturer: E.I.P.I.Ko EG
- Country of Origin: Egypt
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