Buy Thermikon cream 1%, 15 g
  • Buy Thermikon cream 1%, 15 g

Terbinafin

Pharmstandard
1871 Items
2019-09-19
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$30.75
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Clinical Pharmacology

Antifungal drug for local use. It has a wide range of antifungal action.

Active against dermatophytes: Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, Trichophyton verrucosum, Trichophyton violaceum, Microsporum canis, Epidermophyton floccosum. In small concentrations, in addition to dermatophytes, terbinafine has a fungicidal effect against mold, yeast (mainly Candida albicans) and certain dimorphic fungi (Pityrospomm orbiculare). Activity against yeast fungi, depending on their species, can be fungicidal or fungistatic.

Terbinafine in a specific way changes the early stage of sterol biosynthesis occurring in fungi. This leads to a deficiency of ergosterol and intracellular accumulation of squalene, which causes the death of the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase located on the cell membrane of the fungus.

Thermikon® has no effect on the isoenzymes of the cytochrome P450 system in humans and, accordingly, on the metabolism of hormones or other drugs.

Indications

- prevention and treatment of fungal infections of the skin, including mycoses of the feet (tinea pedis), inguinal athlete's (tinea cruris), fungal infections of the smooth skin of the body (tinea corporis) caused by dermatophytes;

- yeast infections of the skin (mainly caused by Candida albicans), in particular, diaper rash;

- versicolor versicolor (Pityriasis versicolor), caused by Pityrosporum orbiculare.

Composition

1 g of terbinafine hydrochloride 10 g

Terbinafin is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Thermikon Pharmstandard Russia cream
Exifin Dr. Reddy`s India pills
Exifin Dr. Reddy`s India cream
Terbinafin Vertex Russia pills
Terbinafin Vips Med Firm Russia spray
Terbinafin Vertex Russia cream
Thermikon Pharmstandard Russia spray
Thermikon Pharmstandard Russia pills
Terbinafin Canonpharma Russia pills
Terbinafin Moscow Pharmaceutical Factory Russia ointment
Terbinafin-Teva Teva Israel pills
Exiter Ozon Russia pills
Funterbin Nizhpharm Russia spray
Lamisil uno Novartis Switzerland solution
Atifin Krka dd Novo mesto AO Slovenia cream
Lamisil Novartis Switzerland cream
Binafin Shreya India pills
Binafin Shreya India cream
Terbisil Gedeon Richter Hungary pills
Terbisil Gedeon Richter Hungary cream
Lamisil Dermgel Novartis Switzerland gel
Funterbin Nizhpharm Russia cream
Lamisil Novartis Switzerland pills
Lamisil Novartis Switzerland spray

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Terbinafin

Dosage and Administration

Topically.

Thermicon spray adults can be applied 1 or 2 times a day, depending on the evidence.
Before using the drug, thoroughly clean and dry the affected skin.
In the process of using the balloon (bottle) should be kept vertically.
To ensure uniform spraying of the contents, preliminarily make several short pressings on the spray nozzle.
The drug is applied to the affected skin and the adjacent areas of healthy skin in sufficient quantity to moisturize them.

Duration of treatment and frequency of use of the drug:

  • dermatomycosis of the trunk, legs: 1 week, 1 time per day;
  • ringworm: 1 week, 1 time per day;
  • multi-colored lichen: 1 week, 2 times a day;
  • groin athlete, diaper rash caused by fungi: 1 week, 1 time per day.

Dosing regimen Thermicon spray in the elderly does not differ from the above.

The experience of using Thermicon spray in children under 12 is limited, and therefore the use of the drug in children is not recommended.

Adverse reactions

Local reactions: redness, itching or burning sensation, allergic reactions are possible in places where the cream is applied.

Contraindications

Hypersensitivity to the drug.

WITHcaution: the drug should be used for hepatic and / or renal failure, alcoholism, inhibition of bone marrow hematopoiesis, tumors, metabolic diseases, occlusive vascular diseases of the extremities, in children under 12 years old (lack of sufficient clinical experience).

Pregnancy and Lactation

The Thermicon should be applied according to strict indications and in case the intended benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, the teratogenic properties of terbinafine have not been identified. To date, no developmental defects have been reported with the use of a thermicon.

Terbinafine is excreted in breast milk. However, in the case of the use of Thermicon nursing mother spray a small amount of the active substance is absorbed through the skin, therefore, an adverse effect on the infant is unlikely.

Special instructions

Reducing the severity of clinical manifestations is usually observed in the first days of treatment. In the case of irregular treatment or its premature termination, there is a risk of recurrence of the infection. In the event that after a week of treatment there are no signs of improvement, the diagnosis should be verified.

Care should be taken when applying Termikon® spray on damaged skin, as alcohol can cause irritation.

Thermicon spray is for external use only. Avoid contact with eyes, as it may cause irritation. In case of accidental ingestion of the drug in the eyes, they should be immediately washed with running water, and in case of persistent irritation, consult a doctor.

If the drug was accidentally introduced into the respiratory tract during inhalation, then, in the event of any symptoms, and especially when they persist, you should consult with your doctor.

With the development of allergic reactions it is necessary to cancel the drug.

Overdosage

No cases of drug overdose have been reported. If Thermicon® accidentally taken orally, you can expect the development of the same symptoms as with an overdose of pills: headache, nausea, epigastric pain and dizziness.

Treatment: activated charcoal, if necessary - symptomatic supportive therapy.

  • Brand name: Thermikon
  • Active ingredient: Terbinafin
  • Dosage form: Cream for external use 1% white, uniform, with a slight specific smell.
  • Manufacturer: Pharmstandard
  • Country of Origin: Russia

Studies and clinical trials of Terbinafin (Click to expand)

  1. Inhibitory effect of terbinafine on reactive oxygen species (ROS) generation by Candida albicans : Hemmender Einfluss von Terbinafin auf die Bildung reaktiver Sauerstoffspezies von Candida albicans
  2. Pigmentierung des Gesichtes unter Therapie mit Terbinafin
  3. Terbinafin-Topika
  4. Synergistische Effekte der Antimykotika Terbinafin und Itraconazol
  5. Arzneimittelreaktion auf Terbinafin unter dem Bild einer akuten generalisierten exanthematischen Pustulose (AGEP)
  6. Fixes Arzneimittelexanthem auf Terbinafin mit charakteristischem Verteilungsmuster eines Baboon-Syndroms
  7. Long-term post-treatment follow-up of onychomycosis treated with terbinafine: a multicentre trial : Langzeit-Nachuntersuchungen Terbinafin-behandelter Onychomykosen. Eine multizentrische Studie
  8. A case of tinea barbae successfully treated with terbinafine : Erfolgreich mit Terbinafin behandelte Tinea barbae
  9. Systemische Terbinafin-Therapie von Dermatophytosen im Kindesalter : Oral terbinafine in the treatment of dermatophytoses in children
  10. Subakut-kutaner Lupus erythematodes nach Gabe von Terbinafin: ein Fallbericht und Literaturübersicht
  11. In Vitro Effect of Terbinafine on Human Leukocyte Chemotaxis and Chemiluminescence/In vitro-Effekt von Terbinafin auf die Chemotaxis und Chemilumineszenz von Leukozyten des Menschen
  12. Clinical efficacy and tolerability of terbinafine in patients with pityriasis versicolor : Klinische Wirksamkeit und Verträglichkeit von Terbinafin bei Patienten mit Pityriasis versicolor
  13. Terbinafine induces the PMNL priming effect and enhances in vitro PMNL fungicidal activity against Candida albicans blastospores : Terbinafin-bedingte Induktion eines Primingeffekts und Steigerung der Fungizidie von polymorphkernigen Granulozyten gegenuber Candida albicans-Blastosporen in vitro
  14. Clinical and pharmacokinetic investigations of oral terbinafine in patients with tinea unguium : Klinische und pharmakokinetische Untersuchungen zur oralen Terbinafin-Therapie an Patienten mit Tinea unguium
  15. Short therapy for tinea unguium with terbinafine: four different courses of treatment : Terbinafin-Kurztherapie bei Tinea unguium: Vier unterschiedliche Behandlungsvarianten
  16. Terbinafine in the treatment of non-immunocompromised compassionate cases of bronchopulmonary aspergillosis : Terbinafin-Behandlung von Einzelfallen bronchopulmonaler Aspergillose bei abwehrkompetenten Patienten
  17. Oral terbinafine in tinea capitis in children : Orale Terbinafin-Behandlung der kindlichen Tinea capitis
  18. The effect of terbinafin in some extensive dermatomycoses
  19. Effect of Terbinafin and DMSO on The Gene Expression Level of Squalene Synthase (Sqs) and Amorpha-4,11-Diene Synthase (Ads) in Artemisia Annua L
  20. Granuloma trichophyticum Majocchi - Erfolgreiche Behandlung mit Terbinafin - Eine Falldarstellung -
  21. Terbinafin
  22. Terbinafin
  23. A Randomized Comparative Clinical Trial of Terbinafin 1% Cream and Ketoconazole 2% Cream in the Treatment of Pityriasis Versicolor

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