Tetracycline
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Clinical Pharmacology
Tetracycline is a broad spectrum bacteriostatic antibiotic from the tetracycline group. Disrupts the formation of a complex between transport RNA and the ribosome, which leads to disruption of protein synthesis. Active against gram-positive (Staphylococcus spp, including penicillinase;. Streptococcus spp (including Streptococcus pneumoniae);. Haemophilus influenzae, Listeria spp, Bacillus anthracis.) And gram-negative bacteria (Neisseria gonorrhoeae, Bordetella pertussis, Escherichia coli, Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp.), And also Ricketsia spp., Chlamydia spp., Mycoplasma spp., Treponema spp. Resistant: Pseudomonas aeruginosa, Proteus spp., Serratia spp., Most strains of Bacteroides spp. and fungi, small viruses, beta-hemolytic streptococci of group A (including 44% of strains of Streptococcus pyogenes and 74% of strains of Streptococcus faecalis).
Indications
Bacterial and chlamydial eye infections:
- Blepharitis
- Blepharoconjunctivitis.
- Keratitis
- Keratoconjunctivitis.
- Meybomite.
- Trachoma.
- Damage to the eyes with pink acne.
Composition
1 g eye ointment contains:
active substances: tetracycline 10 mg;
Excipients: anhydrous lanolin, vaseline
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Dosage and Administration
Placed behind the eyelid every 2-4 hours or more.
The duration of use depends on the form of the disease: with trachoma - 1-2 months or longer (possibly a combination with systemic drugs).
Adverse reactions
The possibility of developing allergic reactions.- Active ingredient: Tetracycline
Studies and clinical trials of Tetracycline (Click to expand)
- Intraoperative topical tetracycline sclerotherapy following mastectomy: A prospective, randomized trial
- A Set of Vectors with a Tetracycline-Regulatable Promoter System for Modulated Gene Expression inSaccharomyces cerevisiae
- Functional analysis of yeast essential genes using a promoter-substitution cassette and the tetracycline-regulatable dual expression system
- Treatment of malignant pleural effusions with a combination of bleomycin and tetracycline: A comparison of bleomycin or tetracycline alone versus a combination of bleomycin and tetracycline
- Rapid analysis of tetracycline antibiotics by combined solid phase microextraction/high performance liquid chromatography/mass spectrometry
- Efficiency of physical (light) or chemical (ABA, tetracycline, CuSO4 or 2-CBSU)-stimulus-dependent gus gene expression in tobacco cell suspensions
- Tetracycline-Regulated overexpression of glycosyltransferases in Chinese hamster ovary cells
- Neurite outgrowth can be modulated in vitro using a tetracycline-repressible gene therapy vector expressing human nerve growth factor
- Conditionally-immortalized astrocytic cell line expresses GAD and secretes GABA under tetracycline regulation
- Tetracycline release from bioerodible hydrogels based on semiinterpenetrating polymer networks composed of poly(ε-caprolactone) and poly(ethylene glycol) macromer in vitro
- Characterization of soluble, salt-loaded, degradable PLGA films and their release of tetracycline
- Transcriptional downregulation of stromelysin by tetracycline
- Homogeneous tetracycline-regulatable gene expression in mammalian fibroblasts
- Separation of tetracycline and its related substances: comparison of liquid chromatography, capillary electrophoresis and capillary electrochromatography
- Determination of tetracycline residues in animal tissues by liquid chromatography
- THE INFLUENCE OF COFFEE WITH MILK AND TEA WITH MILK ON THE BIOAVAILABILITY OF TETRACYCLINE
- Chemiluminometric β-galactosidase detection as a basis for a tetracycline screening test in milk
- The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant
- A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells
- Tetracycline ultraviolet fluorescence in bladder carcinoma
- Ultraviolet fluorescence of bladder tumors following oral administration of tetracycline compounds. A macroscopic, microscopic and fluorescence spectrophotometric study
- Tetracycline and quinacrine in the control of malignant pleural effusions. A randomized trial
- Intrapleural tetracycline in malignant pleural effusions: A randomized study
- Tetracycline pleurodesis for malignant pleural effusions A 10-year retrospective study