Teveten plus [Eprosartan]

Brand Abbott

In stock 1518 Items

Available since: 2019-09-19

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Clinical Pharmacology

Tevet Plus has a hypotensive, vasodilating, diuretic effect.

Indications

Arterial hypertension.

Composition

1 tab. contains eprosartan mesilate 735.8 mg (corresponds to 600 mg of eprosartan), hydrochlorothiazide 12.5 mg;
Excipients: MCC - 43.3 mg; lactose monohydrate - 43.3 mg; gelatinized corn starch - 43.3 mg; crospovidone - 38.5 mg; magnesium stearate - 7.2 mg; purified water - 50.9 mg;
shell: Opadry (OY3736) - 31 mg (hypromellose, macrogol 400, dyes: titanium dioxide E171, iron oxide black E172, iron oxide yellow E172).

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Dosage and Administration

Tevet Plus take orally, 1 tab. per day, in the morning, regardless of the meal.
The selection of the dose of Teveten Plus in elderly patients, patients with mild and moderate liver dysfunction, as well as patients with impaired renal function (Cl creatinine more than 30 ml / min) is not required.

Adverse reactions

The overall incidence of side effects reported in patients taking eprosartan is comparable to that taken with placebo. These actions, as a rule, were mild and short-lived, so only 4.1% of patients who took eprosartan during placebo-controlled clinical trials took cessation of treatment (6.5% in the placebo group).
From the side of the central nervous system: seldom - headache, dizziness, asthenia.
Since the cardiovascular system: very rarely - decreased blood pressure, incl. postural hypotension.
Skin and subcutaneous adipose tissue: rarely - skin reactions (rash, itching and urticaria); very rarely - swelling of the face, angioedema.
Other: rarely cough.

Contraindications

Hypersensitivity to Tevetin Plus components;
pregnancy;
breastfeeding period;
age up to 18 years (efficacy and safety have not been established).
Carefully:
severe heart failure III – IV FC (by NYHA);
bilateral renal artery stenosis, renal artery stenosis of a single kidney;
decrease in BCC as a result of vomiting, diarrhea, receiving high doses of diuretics.
The company does not have data on Teveten's safety in patients with terminal renal insufficiency (Cl creatinine less than 5 ml / min, uremia II), as well as in patients on hemodialysis.

Drug interactions

The antihypertensive effect may increase with simultaneous use with other antihypertensive agents.

When used in conjunction with oral hypoglycemic agents, it is necessary to adjust their dose, because hydrochlorothiazide may decrease glucose tolerance.

With simultaneous use with lithium preparations, a reversible increase in plasma lithium concentration and an increase in the risk of its toxic effects may occur (careful monitoring of lithium concentration in patients receiving this combination is necessary).

NSAIDs can reduce the diuretic and hypotensive effect of Teveten Plus.

By lowering potassium, hydrochlorothiazide may enhance the action of cardiac glycosides and some antiarrhythmic drugs.

Hydrochlorothiazide increases the risk of hypokalemia when it is prescribed together with drugs that cause the body to lose potassium, for example, diuretics that have a potassium uretic effect, laxatives, GCS and ACTH.

Hydrochlorothiazide may enhance the action of non-depolarizing muscle relaxants (for example, tubocurarine). The absorption of hydrochlorothiazide is reduced when anion exchange resins are taken together (for example, colestiramine or colestipol).

Special instructions

Based on the pharmacodynamic properties, Teveten Plus should not affect the ability to drive and use machines and mechanisms. During the treatment of hypertension, care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and psychomotor speed, due to the fact that dizziness and weakness may occur.

Overdosage

Data on Teveten's overdose plus is currently not available. Among the symptoms, it is possible to suggest the following: an excessive decrease in blood pressure, dehydration and electrolyte imbalance (hypokalemia, hypochloremia, hyponatremia), manifested in the form of nausea and drowsiness.
Treatment depending on the time elapsed after a meal, the measures taken should include the stimulation of vomiting, gastric lavage and / or ingestion of Activated charcoal.
With a sharp decrease in blood pressure it is recommended to lay the patient on his back, lift his legs, if necessary, introduce plasma-substituting fluids. Symptomatic and supportive therapy is recommended for dehydration and impaired water-salt balance. Hemodialysis is not effective.