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Thiamine plays an important role in the life of the body, is part of a number of enzymes and is involved in carbohydrate metabolism, in the decarboxylation of a-keto acid and the synthesis of acetyl CoA. It has an impact on the conduct of nervous excitement in synapses, has ganglioblokiruyuschimi and curare-like properties. Of great importance for the function of the nervous system, digestive apparatus, cardiac activity, as well as the endocrine system.
The source of thiamine for humans is food. In the absence or inadequate intake of food or in various conditions that prevent its absorption and absorption, the person develops the phenomenon of hypo-and avitaminosis B1. The initial stages of vitamin B1 deficiency are characterized by nervous disorders (neurasthenia, headaches, migraine, fatigue, insomnia, pain and sensitivity disorders in the limbs, muscle weakness, calf cramps), cardiovascular disorders (shortness of breath, expansion of the borders of the heart, rhythm disturbance) and digestive organs (anorexia, intestinal atony, constipation). Beriberi B1, called beriberi, occurs either with paralysis and exhaustion, or with heart damage and edema. Thiamine, taken orally, is absorbed in the small intestine, partially undergoing inactivation of the thiaminase.
Hypovitaminosis and avitaminosis B1, incl. in patients on probe nutrition, hemodialysis, with malabsorption syndrome. The complex therapy includes neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakov’s psychosis, chronic liver damage, various intoxications, myocardiodystrophy, impaired coronary blood circulation, gastric ulcer and 12 duodenal ulcer, and atonicone, atopiconectomy, atopic and aortic ulcer, atopic and aortic ulcer, atopic syndrome intestines; thyrotoxicosis, diabetes mellitus, endarteritis; dermatosis (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; pyoderma.
1 ml of the medicinal product contains 0,050 g of thiamine chloride
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Dosage and Administration
Inside before eating. Before use, dilute in a little water.
12-15 drops 3 times a day. The duration of therapy is determined by the attending physician. Shake before use.
- Allergic reactions are possible.
- irritation of the mucous membrane of the gastrointestinal tract,
Carefully: alcoholism; traumatic brain injury; brain diseases; children's age (over 12 years).
The action of thiamine decreases with simultaneous use with sulphite-containing infusion solutions.
Fluorouracil, vinblastine, bleomycin, cisplatin violate the absorption of vitamin B1. Penicillamine, isoniazid reduce the effectiveness of vitamin B1by increasing its excretion.
Pregnancy and Lactation
Due to the lack of sufficient research, the drug is not recommended to be taken during pregnancy and during breastfeeding.
The drug Eskuzan contains 31% ethanol. If the recommended dosage is observed, each time the drug is taken up to the body receives up to 0.128 g of ethanol, and the maximum daily dose of the drug contains up to 0.384 g of ethanol.
During long-term storage of drugs (liquid dosage forms) based on medicinal plant materials, the solution may cloud and precipitate out, which does not affect the quality of the drug.
Influence on ability to steer vehicles and work with mechanisms. During the period of use of the drug, care should be taken when performing potentially hazardous activities that require increased attention and speed of psychomotor reactions (driving and other vehicles, working with moving machinery, the work of the dispatcher and operator).
Symptoms: perhaps a feeling of heaviness in the epigastric region.
Treatment: symptomatic. Drug should be canceled.
- Active ingredient: Thiamine
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