Thiamine
Yerevan HFF
601 Items
2019-09-19
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Clinical Pharmacology
Thiamine plays an important role in the life of the body, is part of a number of enzymes and is involved in carbohydrate metabolism, in the decarboxylation of a-keto acid and the synthesis of acetyl CoA. It has an impact on the conduct of nervous excitement in synapses, has ganglioblokiruyuschimi and curare-like properties. Of great importance for the function of the nervous system, digestive apparatus, cardiac activity, as well as the endocrine system.
The source of thiamine for humans is food. In the absence or inadequate intake of food or in various conditions that prevent its absorption and absorption, the person develops the phenomenon of hypo-and avitaminosis B1. The initial stages of vitamin B1 deficiency are characterized by nervous disorders (neurasthenia, headaches, migraine, fatigue, insomnia, pain and sensitivity disorders in the limbs, muscle weakness, calf cramps), cardiovascular disorders (shortness of breath, expansion of the borders of the heart, rhythm disturbance) and digestive organs (anorexia, intestinal atony, constipation). Beriberi B1, called beriberi, occurs either with paralysis and exhaustion, or with heart damage and edema. Thiamine, taken orally, is absorbed in the small intestine, partially undergoing inactivation of the thiaminase.
Indications
Hypovitaminosis and avitaminosis B1, incl. in patients on probe nutrition, hemodialysis, with malabsorption syndrome. The complex therapy includes neuritis and polyneuritis, radiculitis, neuralgia, peripheral paresis and paralysis, Wernicke's encephalopathy, Korsakov’s psychosis, chronic liver damage, various intoxications, myocardiodystrophy, impaired coronary blood circulation, gastric ulcer and 12 duodenal ulcer, and atonicone, atopiconectomy, atopic and aortic ulcer, atopic and aortic ulcer, atopic syndrome intestines; thyrotoxicosis, diabetes mellitus, endarteritis; dermatosis (eczema, atopic dermatitis, psoriasis, lichen planus) with neurotrophic changes and metabolic disorders; pyoderma.
Composition
1 ml of the medicinal product contains 0,050 g of thiamine chloride
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Dosage and Administration
Inside before eating. Before use, dilute in a little water.
12-15 drops 3 times a day. The duration of therapy is determined by the attending physician. Shake before use.
Adverse reactions
- Allergic reactions are possible.
- irritation of the mucous membrane of the gastrointestinal tract,
- headaches,
- dizziness.
Contraindications
Carefully: alcoholism; traumatic brain injury; brain diseases; children's age (over 12 years).
Drug interactions
The action of thiamine decreases with simultaneous use with sulphite-containing infusion solutions.
Fluorouracil, vinblastine, bleomycin, cisplatin violate the absorption of vitamin B1. Penicillamine, isoniazid reduce the effectiveness of vitamin B1by increasing its excretion.
Pregnancy and Lactation
Due to the lack of sufficient research, the drug is not recommended to be taken during pregnancy and during breastfeeding.
Special instructions
The drug Eskuzan contains 31% ethanol. If the recommended dosage is observed, each time the drug is taken up to the body receives up to 0.128 g of ethanol, and the maximum daily dose of the drug contains up to 0.384 g of ethanol.
During long-term storage of drugs (liquid dosage forms) based on medicinal plant materials, the solution may cloud and precipitate out, which does not affect the quality of the drug.
Influence on ability to steer vehicles and work with mechanisms. During the period of use of the drug, care should be taken when performing potentially hazardous activities that require increased attention and speed of psychomotor reactions (driving and other vehicles, working with moving machinery, the work of the dispatcher and operator).
Overdosage
Symptoms: perhaps a feeling of heaviness in the epigastric region.
Treatment: symptomatic. Drug should be canceled.
- Active ingredient: Thiamine
Studies and clinical trials of Thiamine (Click to expand)
- OTC Product: Theraflu Thin Strips
- Effect of thermal processing on available lysine, thiamine and riboflavin content in soymilk
- Mapping of gene controlling thiamine transport inSaccharomyces cerevisiae
- Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency
- Regional activation of L-type voltage-sensitive calcium channels in experimental thiamine deficiency
- Early microglial response in experimental thiamine deficiency: An immunohistochemical analysis
- Flow-injection spectrophotometric determination of vitamin B1 (thiamine) in multivitamin preparations
- Ultrastructural Changes in the Intestinal Absorptive Cells of the Mouse Induced by Capsaicin in Relation to Thiamine Absorption
- A family of multifunctional thiamine-repressible expression vectors for fission yeast
- Isolation and characterization of Saccharomyces cerevisiae mutants with derepressed thiamine gene expression
- Comparative thiamine saturations in women with uterine cancer and in normal women
- Thiamine deficiency in hematologic malignant tumors
- Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: An in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy
- Mitochondrial myopathy and familial thiamine deficiency
- The spectrum of mutations, including four novel ones, in the thiamine-responsive megaloblastic anemia gene SLC19A2 of eight families
- Synthesis of Stable Analogues of Thiamine Di- and Triphosphate as Tools for Probing a New Phosphorylation Pathway
- Effect of thiamine hydrochloride, pyridoxine hydrochloride and calcium-d-pantothenate on the patulin content of apple juice concentrate
- In vivo and in vitro proton NMR spectroscopic studies of thiamine-deficient rat brains
- [Advances in Enzymology - and Related Areas of Molecular Biology] Advances in Enzymology and Related Areas of Molecular Biology (Meister/Advances) || Biosynthesis of Riboflavin, Folic Acid, Thiamine, and Pantothenic Acid
- Branched-Chain Keto Acid Decarboxylase from Lactococcus lactis (KdcA), a Valuable Thiamine Diphosphate-Dependent Enzyme for Asymmetric CC Bond Formation
- Localization of thiamine pyrophosphatase in synaptic vesicles
- Histochemical studies on the distribution of thiamine pyrophosphatase and enzymes related to carbohydrate metabolism in the intercalated neurons of the rat supraoptic nucleus
- Novel mutation in the SLC19A2 gene in an African-American female with thiamine-responsive megaloblastic anemia syndrome
- Direct genomic PCR sequencing of the high affinity thiamine transporter (SLC19A2) gene identifies three genetic variants in Wernicke Korsakoff syndrome (WKS)
- Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy
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