Buy Thiotriazoline pills 100 mg, 50 pcs
  • Buy Thiotriazoline pills 100 mg, 50 pcs

Thiotriazoline

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Clinical Pharmacology

The pharmacological effect is due to anti-ischemic, antioxidant, membrane stabilizing and immunomodulating properties. It prevents the death of hepatocytes, reduces the degree of their fatty infiltration and the spread of centrolobular necrosis of the liver, promotes the process of regeneration of hepatocytes, normalizes protein, carbohydrate, lipid and pigment exchanges. Increases the amount of synthesis and secretion of bile, normalizes its chemical composition.

Thiotriazolin® enhances the compensatory activation of anaerobic glycolysis, reduces the inhibition of oxidation processes in the Krebs cycle while maintaining the intracellular ATP pool. The drug activates the antioxidant system and inhibits the oxidation of lipids in ischemic sites. Improves the rheological properties of blood (activates the fibrinolytic system). Antioxidant properties are manifested due to the presence of a sulfur ion in the Thiotriazoline® molecule structure, which is characterized by redox features, and tertiary nitrogen, which binds an excess of hydrogen ions. Thiotriazolin® reacts with reactive oxygen species and lipid radicals due to the pronounced reducing properties of the thiol group and prevents the occurrence of reactive oxygen species by reactivating antiradical enzymes such as superoxide dismutase, catalase and glutathione peroxidase.

Indications

  • Toxic liver damage, incl. alcohol, viral and medicinal origin (antibiotics, anticancer, anti-tuberculosis, antiviral drugs, tricyclic antidepressants, oral contraceptives, etc.).
  • Chronic alcoholic hepatitis of minimal and moderate activity.
  • Chronic viral hepatitis.
  • Fatty degeneration of the liver.
  • Cirrhosis of the liver.

Composition

Active substance: morpholinium-methyl-triazolyl-thioacetate (thiotriazolin®) 100 mg (based on 100% of the substance).

Excipients: potato starch, low molecular weight povidone, sucrose, microcrystalline cellulose, calcium stearate.

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Thiotriazoline

Dosage and Administration

Inside Thiotriazolin® is prescribed 1 to 2 pills 3-4 times a day for 20 to 30 days. The duration of the course of treatment is determined by the doctor individually, depending on the severity and characteristics of the course of the disease.

Adverse reactions

Thiotriazolin® is generally well tolerated. In the clinical application of Thiotriazolin®, isolated cases of adverse reactions were observed:

From the gastrointestinal tract: nausea, dry mouth, bloating.

From the central and peripheral nervous system: general weakness, dizziness, tinnitus.

Since the cardiovascular system: tachycardia, increased blood pressure, pain in the heart, arrhythmias.

On the part of the respiratory system: very rarely - shortness of breath, asthma.

Allergic reactions: hypersensitivity reactions, fever, very rarely - angioedema.

On the part of the skin: itching, skin flushing, urticaria.

Contraindications

  • Hypersensitivity to the drug.
  • Renal failure.
  • Childhood.
  • The period of pregnancy and lactation.

Pregnancy and Lactation

Contraindicated in pregnancy and lactation.

Special instructions

The pills contain sucrose - 2.8 mg per tablet, i.e. The maximum daily dose (8 pills) contains 22.4 mg of sucrose, which patients with diabetes need to take into account.

Overdosage

Cases of overdose are unknown. When ingesting a large amount of the drug - it is necessary to make a gastric lavage. Symptomatic treatment.

  • Active ingredient: Thiotriazoline

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