Tilorone
Pharmstandard
15 Items
2019-09-19
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Clinical Pharmacology
Amixin - antiviral and immunomodulatory drugs. Amixin stimulates the formation in the body of interferon alpha, beta, gamma. The main structures producing interferon in response to the administration of Amixin are intestinal epithelial cells, hepatocytes, T-lymphocytes, neutrophils. After taking the drug inside the maximum production of interferon is determined in the sequence of the intestine-liver-blood after 4-24 hours. Amixin has an immunomodulatory and antiviral effect.
Stimulates bone marrow stem cells, enhances antibody production, depending on the dose, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helper cells. Effective against various viral infections (including those caused by influenza viruses, other causative agents of acute respiratory viral infections, hepatitis viruses, herpes). The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which reproduction of viruses is inhibited.
Indications
In adults:
For the treatment of viral hepatitis A, B and C.
For the treatment of herpes infection.
For the treatment of cytomegalovirus infection.
As part of complex therapy of allergic and viral encephalomyelitis (including multiple sclerosis, leukoencephalitis, uveoencephalitis).
In the complex therapy of urogenital and respiratory chlamydia.
In the complex treatment of pulmonary tuberculosis.
For the prevention and treatment of influenza and SARS.
In children over 7 years old
For the treatment of influenza and SARS.
Composition
1 tablet contains Tilorone 125 mg,
Excipients: magnesium carbonate basic, polyvinylpyrrolidone, calcium stearate, aerosil, vaseline oil, sugar, talc, tropeolin O, titanium dioxide, gelatin, beeswax.
Tilorone is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Amixin | Pharmstandard | Russia | pills |
| Lavamax | Nizhpharm | Russia | pills |
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Dosage and Administration
The drug is taken orally after a meal.
Appointment to children older than 7 years with uncomplicated forms of influenza and other acute respiratory viral infections
For children over 7 years old with uncomplicated forms of influenza or other acute respiratory viral infections, the drug is prescribed in a dose of 60 mg (1 tab.) 1 time / day after meals on the 1st, 2nd and 4th day from the start of treatment. Heading dose - 0.18 g (3 tab.).
The development of complications of influenza and other acute respiratory viral infections.
With the development of complications of influenza and other acute respiratory viral infections, the drug is taken on 60 mg 1 time / day on the 1st, 2nd, 4th, 6th day from the start of treatment. Heading dose - 0.24 g (4 tab.).
Adverse reactions
From the digestive system: Symptoms of dyspepsia are possible.
Other: Possible short-term chills. Allergic reactions.
Contraindications
Pregnancy.
Lactation period (breastfeeding).
Children's age up to 7 years.
Hypersensitivity to the drug.
Drug interactions
Amixin is compatible with antibiotics and traditional treatments for viral and bacterial infections.
Pregnancy and Lactation
Amixin is contraindicated for use during pregnancy and lactation.
Overdosage
To date, cases of overdose Amixin unknown.
- Brand name: Amixin
- Active ingredient: Tilorone
- Dosage form: Coated pills.
- Manufacturer: Pharmstandard
- Country of Origin: Russia
Studies and clinical trials of Tilorone (Click to expand)
- Phase II trials of baker's antifol, bleomycin, CCNU, streptozotocin, tilorone, and 5-fluorodeoxyuridine plus arabinosyl cytosine in metastatic breast cancer
- Binding of ligands to a one-dimensional heterogeneous lattice. III. Kinetic model and relaxation study of the interaction of tilorone with DNA and polynucleotides
- Generation and control of metastasis in experimental tumor systems; inhibition of experimental metastases by a tilorone analogue
- Synthesis of 2, 7-bis [2-(diethylamino) ethoxy] fluoren-9 14C-one. 2HCL; (tilorone-914C hydrochloride
- Effect of the immunomodulator tilorone on antipyrine disposition in the rat
- Modulation of the acquisition and expression of immunity by Tilorone: I. Delayed-type hypersensitivity responses
- Modulation of the acquisition and expression of immunity by tilorone: II. Humoral responsiveness
- Suppression of experimental allergic encephalomyelitis by tilorone: cell transfer and interferon studies
- The interaction of tilorone and RMI 9563DA with the complement system
- Mucopolysaccharidosis and lipidosis in rats treated with tilorone analogues
- Performance of tiloronoxim and tilorone determination in human blood by HPLC–MS/MS: Method validation, uncertainty assessment and its application to a pharmacokinetic study
- Impaired macrophage functions as a possible basis of immunomodification by microbial agents, tilorone and dimethyldioctadecylammonium bromide
- Histochemical evidence for lysosomal storage of acid glycosaminoglycans in splenic cells of rats treated with tilorone
- Distribution of14C-tilorone in mice
- Subcellular distribution of14C-tilorone hydrochloride in tissues of mice and rats
- The protective effect of the interferon inducers tilorone hydrochloride and poly I∶C on experimental tick-borne encephalitis in mice
- Comparison of the activity of small molecular interferon inducers: Tilorone and acridine drugs
- A dual effect of tilorone on multiplication ofMycobacterium lepraein mice
- Dissociation between antiinflammatory action of tilorone and its interferon inducing activity
- Induction of cytokines by tilorone hydrochloride
- Mucopolysaccharidosis-like alterations in cardiac valves of rats treated with tilorone
- Tilorone-induced lysosomal storage mimicking the features of mucopolysaccharidosis and of lipidosis in rat liver
- Antiviral and Anticancer Activity of Cisplatin Derivatives of Tilorone
- Improved synthesis of 2,7-dihydroxyfluorenone in the manufacture of tilorone with application of a rotor—stator system
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