Tobramycin

Brand Alcon

In stock 1311 Items

Available since: 2019-09-19

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Clinical Pharmacology

A broad-spectrum antibiotic from the group of aminoglycosides. It has a bactericidal effect, disrupting protein synthesis and the permeability of the cytoplasmic membrane of the microbial cell.

Pharmacokinetics

When applied topically, systemic absorption is low.

Indications

Infections of the eye and its appendages:

blepharitis;
conjunctivitis;
keratoconjunctivitis;
blepharoconjunctivitis;
keratitis;
iridocyclitis;

Prevention of postoperative infections in ophthalmology.

Composition

1 ml of eye drops contains:
active substances: tobramycin 3 mg;
Excipients: xanthan gum, mannitol, boric acid, trometamol, polysorbate 80, benzododecinium bromide, sulfuric acid and / or sodium hydroxide (to bring the pH), purified water

Tobramycin is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Tobrex 2X	Alcon	USA	eye drops
Tobropt	K.O.Romparm Company S.R.L	Romania	eye drops
Tobrex	Alcon	USA	eye drops

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Dosage and Administration

The drug should be applied topically with 1 drop every 4 hours.

With acute infections instillation can be repeated every 30 minutes or 1 hour.

With mild infectious process 1-2 drops are instilled into the conjunctival sac of the affected eye (or eyes) every 4 hours.

With acute severe infectious process (endophthalmitis) The drug is instilled into the conjunctival sac every 30-60 minutes, as the inflammation decreases, the incidence of instillations decreases.

Adverse reactions

Allergic reactions: in 15% of cases - burning, paresthesia, conjunctival itching; in 1-5% of cases - hyperemia of the mucous membrane of the eye, foreign body sensation in the eye, lacrimation;

Contraindications

children and adolescents up to 18 years;
pregnancy;
lactation period (breastfeeding);
hypersensitivity to the drug.

Drug interactions

With simultaneous use of Tobropta with systemic antibiotics from the group of aminoglycosides, systemic side effects (including nephrotoxic, ototoxic effects, disorders of mineral metabolism and hematopoiesis) may be enhanced.

Pregnancy and Lactation

The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.

Special instructions

Tobropt is intended for local use only.

The bottle must be closed after each use. In order to maintain the sterility of the solution, do not touch the eye with a pipette tip.

Prolonged use of the drug can lead to enhanced growth of resistant microorganisms (including fungi). It is recommended to do seeding after the end of treatment if the clinical result is unsatisfactory.

Patients using hard contact lenses should use eye drops only after removing contact lenses. Lenses can be worn 15 minutes after instillation of the drug. During the period of treatment can not wear soft contact lenses.

With the development of allergic reactions use of the drug should be discontinued.

Shake the bottle before use.

Influence on ability to drive motor transport and control mechanisms

The use of the drug does not cause fatigue and visual impairment and, accordingly, does not affect the ability to drive vehicles and control mechanisms. Patients whose visual clarity is temporarily lost after the application are not recommended to drive a car or work with a complex technique immediately after instillation of the drug.