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Tolperisone

Obolensky OP
1440 Items
2019-09-19
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$24.31
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Clinical Pharmacology

Tolperisone OBL - muscle relaxant, has a selective inhibitory effect on the caudal part of the reticular formation of the brain, has central holinoblokiruyuschimi properties.

It has no effect on the peripheral parts of the nervous system, has a weak antispasmodic and vasodilating effect.

Indications

  • spinal and cerebral paralyzes (hypertonus, muscle spasm, spinal automatism; limb contracture).
  • diseases with dystonia, rigidity, muscle spasm; arterial disease obliterans: obliterating atherosclerosis of the limb vessels, diabetic angiopathy, thromboangiitis obliterans (Buerger's disease), Raynaud's syndrome.
  • effects of disorders of vascular innervation (acrocyanosis, "intermittent" angioedema).
  • extrapyramidal disorders (post-encephalic and atherosclerotic parkinsonism).
  • postthrombotic disorders of lymph circulation and venous circulation, trophic ulcer of the leg, children spastic paralysis (Little disease), epilepsy, vascular genesis encephalopathy; hypertonus in combination with a violation of muscle tone of another type.

Composition

1 tablet contains: Tolperisone hydrochloride - 50 mg.

Excipients: citric acid, lactose monohydrate (milk sugar), hyprolose (hydroxypropylcellulose), crospovidone, stearic acid.

Shell auxiliaries: Opadry II (Series 85) [polyvinyl alcohol, macrogol (polyethylene glycol), talc, titanium dioxide].

Tolperisone is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Obolensky OP Russia pills
Mydocalm Gedeon Richter Hungary pills

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Tolperisone

Dosage and Administration

Inside

For adults, the initial dose of 50 mg 2-3 times a day, with a gradual increase to 150 mg 2-3 times a day.

The duration of the course of treatment depends on the severity and nature of the course of the disease.

Adverse reactions

  • headache,
  • myasthenia gravis
  • decrease in blood pressure
  • nausea,
  • vomiting
  • gastralgia,
  • allergic reactions (anaphylactic shock, bronchospasm, urticaria, erythematous rash, pruritus).

Contraindications

  • hypersensitivity (including to lidocaine),
  • myasthenia gravis
  • children's age (up to 1 year).

Drug interactions

Drugs for general anesthesia, peripheral muscle relaxants, psychoactive drugs, clonidine enhance the effect.

Pregnancy and Lactation

Contraindicated during pregnancy and lactation.

Special instructions

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Overdosage

Symptoms: respiratory depression and cardiac activity, lowering blood pressure.

Treatment: symptomatic.

  • Brand name: Mydocalm
  • Active ingredient: Tolperisone
  • Dosage form: pills, film coated.
  • Manufacturer: Obolensky OP
  • Country of Origin: Russia

Studies and clinical trials of Tolperisone (Click to expand)
  1. Synthesis of 3H-tolperisone
  2. Tolperisone: Evaluation of the Lidocaine-Like Activity by Molecular Modeling
  3. Gas—liquid chromatographic method for the determination of tolperisone in human plasma: pharmacokinetic and comparative bioavailability studies
  4. NMR analysis, protonation equilibria and decomposition kinetics of tolperisone
  5. Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography
  6. Simultaneous micellar LC determination of lidocaine and tolperisone
  7. High performance thin layer chromatographic determination of tolperisone hydrochloride
  8. Synthesis and resolution of a Tolperisone metabolite
  9. Synthesis, resolution and absolute configuration of a tolperisone metabolite
  10. Synthesis of some tolperisone metabolites in racemic and optically active form
  11. Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force – a double-blind randomized crossover control study
  12. Comprehensive studies of Tolperisone·HCl-cyclodextrin complexes
  13. Optimization of the reversed-phase high-performance liquid chromatographic separation of the enantimers of a cationic chiral drug (tolperisone) on a heptakis(6-azido-6-deoxy) perphenylcarbamated β-cyclodextrin column
  14. HPLC Determination of tolperisone in human plasma
  15. A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke
  16. Tolperisone: A Typical Representative of a Class of Centrally Acting Muscle Relaxants with Less Sedative Side Effects
  17. LC-UV Assay of Tolperisone HCl from Sustained Release Matrix Tablets
  18. A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms
  19. Fatal tolperisone poisoning: Autopsy and toxicology findings in three suicide cases
  20. Efficacy and tolerance of repeated oral doses of tolperisone hydrochloride in the treatment of painful reflex muscle spasm: results of a prospective placebo-controlled double-blind trial
  21. Determination of tolperisone in human plasma by liquid chromatography/tandem mass spectrometry for clinical application
  22. Tolperisone disappoints in phase IIb study in spasticity
  23. PP136—Genetic polymorphism of CYP2D6 significantly affects the pharmacokinetics of tolperisone
  24. PP124—Pharmacokinetics of tolperisone in relation to CYP2C19 genotypes

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