Tolterodine
Ranbaxy Laboratories Ltd
745 Items
2019-09-19
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Clinical Pharmacology
Roliten has anticholinergic, antispasmodic effect.
Indications
Hyperreflexia (hyperactivity, instability) of the bladder, manifested by frequent, imperative urination and / or incontinence.
Composition
1 tab. contains tolterodine tartrate 2 mg;
Excipients: MCC; calcium phosphate; sodium carboxymethyl starch (type A); colloidal silicon dioxide; magnesium stearate;
film cover: Opadry white dye (OY-S-58910) (composed of: hypromellose, titanium dioxide, macrogol 400, talc); purified water
Tolterodine is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Roliten | Ranbaxy Laboratories Ltd | India | pills |
| Urotol | Zentiva KS | Czech | pills |
No customer reviews for the moment.
Dosage and Administration
Roliten is taken orally, 2 mg 2 times a day. With hepatic and / or renal failure, as well as in the case of side effects, the dose is reduced to 1 mg 2 times a day.
After 6 months, the need for further treatment should be assessed.
Adverse reactions
The frequency of side effects was determined as follows: often - more than 10%; not often - 1–10%; rarely less than 1%
Side effects associated with anticholinergic action: often - dry mouth; not often - accommodation disturbances, reduced tearing (xerophthalmia), dry skin; rarely - urinary retention.
From the digestive system: not often - dyspepsia, constipation, abdominal pain, flatulence, vomiting; rarely - gastroesophageal reflux.
CNS and peripheral nervous system: not often - headache, dizziness, drowsiness, nervousness, paresthesias; rarely - impaired consciousness.
Other: not often - weakness, fatigue, weight gain; rarely - chest pain; allergic reactions, flushing to the skin of the face.
Contraindications
hypersensitivity;
urinary retention;
angle-closure glaucoma (non-treatable);
myasthenia gravis;
ulcerative colitis;
megacolon;
pregnancy;
lactation period;
childhood.
Carefully: obstruction of the urinary tract, obstructive lesions of the gastrointestinal tract, neuropathy, irreducible hernia.
- Brand name: Roliten
- Active ingredient: Tolperisone
- Dosage form: pills, film coated.
- Manufacturer: Obolensky OP
- Country of Origin: Russia
Studies and clinical trials of Tolterodine (Click to expand)
- Serum protein binding of tolterodine and its major metabolites in humans and several animal species
- Cost-effectiveness of new treatments for overactive bladder: The example of tolterodine, a new muscarinic agent: A Markov model
- Catalytic Asymmetric Total Synthesis of the Muscarinic Receptor Antagonist (R)-Tolterodine
- ChemInform Abstract: Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones.
- Enantioselective [4 + 2] Cycloadditions of o-Quinone Methides: Total Synthesis of (+)-Mimosifoliol (I) and Formal Synthesis of (+)-Tolterodine (II).
- Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine.
- Enantioselective Synthesis of (S)- and (R)-Tolterodine (I) by Asymmetric Hydrogenation of a Coumarin Derivative Obtained by a Heck Reaction.
- ChemInform Abstract: An Efficient Synthesis of Racemic Tolterodine (VII).
- ChemInform Abstract: Co-Catalyzed Mild and Chemoselective Reduction of Phenyl Esters with NaBH4: A Practical Synthesis of (R)-Tolterodine.
- ChemInform Abstract: Stepwise Palladium-Catalyzed 1,4-Addition of Arylboronic Acids to Enones and Regioselective Baeyer—Villiger Oxidation for Enantioselective Synthesis of β-Diaryl Esters and (+)-(R)-Tolterodine.
- ChemInform Abstract: A Process for the Rapid Removal of Dialkylamino-Substituents from Aromatic Rings. Application to the Expedient Synthesis of (R)-Tolterodine.
- ChemInform Abstract: Rearrangement of Ethers: A New Route to Tolterodine.
- Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction
- Clinical efficacy of tolterodine with or without a simplified pelvic floor exercise regimen
- Urodynamic and other effects of tolterodine: A novel antimuscarinic drug for the treatment of detrusor overactivity
- Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome
- Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects—A placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release
- Tolterodine causes measurable restoration of urethral sensation in women with urge urinary incontinence
- The efficacy of additive tolterodine extended release for 1-year in older men with storage symptoms and clinical benign proastatic hyperplasia
- Investigation of the clinical efficacy and safety of pregabalin alone or combined with tolterodine in female subjects with idiopathic overactive bladder
- Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation
- Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres
- Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine
- Tolterodine (TOL) prolonged release (PR) in children aged 11-15 years
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