Buy Roliten pills 2 mg, 30 pcs
  • Buy Roliten pills 2 mg, 30 pcs

Tolterodine

Ranbaxy Laboratories Ltd
745 Items
2019-09-19
Dosage form
Brand & Manufacturer
Package Size
$40.19
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Clinical Pharmacology

Roliten has anticholinergic, antispasmodic effect.

Indications

Hyperreflexia (hyperactivity, instability) of the bladder, manifested by frequent, imperative urination and / or incontinence.

Composition

1 tab. contains tolterodine tartrate 2 mg;
Excipients: MCC; calcium phosphate; sodium carboxymethyl starch (type A); colloidal silicon dioxide; magnesium stearate;
film cover: Opadry white dye (OY-S-58910) (composed of: hypromellose, titanium dioxide, macrogol 400, talc); purified water

Tolterodine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Roliten Ranbaxy Laboratories Ltd India pills
Urotol Zentiva KS Czech pills

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Tolterodine

Dosage and Administration

Roliten is taken orally, 2 mg 2 times a day. With hepatic and / or renal failure, as well as in the case of side effects, the dose is reduced to 1 mg 2 times a day.
After 6 months, the need for further treatment should be assessed.

Adverse reactions

The frequency of side effects was determined as follows: often - more than 10%; not often - 1–10%; rarely less than 1%
Side effects associated with anticholinergic action: often - dry mouth; not often - accommodation disturbances, reduced tearing (xerophthalmia), dry skin; rarely - urinary retention.
From the digestive system: not often - dyspepsia, constipation, abdominal pain, flatulence, vomiting; rarely - gastroesophageal reflux.
CNS and peripheral nervous system: not often - headache, dizziness, drowsiness, nervousness, paresthesias; rarely - impaired consciousness.
Other: not often - weakness, fatigue, weight gain; rarely - chest pain; allergic reactions, flushing to the skin of the face.

Contraindications

hypersensitivity;
urinary retention;
angle-closure glaucoma (non-treatable);
myasthenia gravis;
ulcerative colitis;
megacolon;
pregnancy;
lactation period;
childhood.
Carefully: obstruction of the urinary tract, obstructive lesions of the gastrointestinal tract, neuropathy, irreducible hernia.

  • Brand name: Roliten
  • Active ingredient: Tolperisone
  • Dosage form: pills, film coated.
  • Manufacturer: Obolensky OP
  • Country of Origin: Russia

Studies and clinical trials of Tolterodine (Click to expand)

  1. Serum protein binding of tolterodine and its major metabolites in humans and several animal species
  2. Cost-effectiveness of new treatments for overactive bladder: The example of tolterodine, a new muscarinic agent: A Markov model
  3. Catalytic Asymmetric Total Synthesis of the Muscarinic Receptor Antagonist (R)-Tolterodine
  4. ChemInform Abstract: Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones.
  5. Enantioselective [4 + 2] Cycloadditions of o-Quinone Methides: Total Synthesis of (+)-Mimosifoliol (I) and Formal Synthesis of (+)-Tolterodine (II).
  6. Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Coumarins: Asymmetric Synthesis of (R)-Tolterodine.
  7. Enantioselective Synthesis of (S)- and (R)-Tolterodine (I) by Asymmetric Hydrogenation of a Coumarin Derivative Obtained by a Heck Reaction.
  8. ChemInform Abstract: An Efficient Synthesis of Racemic Tolterodine (VII).
  9. ChemInform Abstract: Co-Catalyzed Mild and Chemoselective Reduction of Phenyl Esters with NaBH4: A Practical Synthesis of (R)-Tolterodine.
  10. ChemInform Abstract: Stepwise Palladium-Catalyzed 1,4-Addition of Arylboronic Acids to Enones and Regioselective Baeyer—Villiger Oxidation for Enantioselective Synthesis of β-Diaryl Esters and (+)-(R)-Tolterodine.
  11. ChemInform Abstract: A Process for the Rapid Removal of Dialkylamino-Substituents from Aromatic Rings. Application to the Expedient Synthesis of (R)-Tolterodine.
  12. ChemInform Abstract: Rearrangement of Ethers: A New Route to Tolterodine.
  13. Effects of ATP-sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction
  14. Clinical efficacy of tolterodine with or without a simplified pelvic floor exercise regimen
  15. Urodynamic and other effects of tolterodine: A novel antimuscarinic drug for the treatment of detrusor overactivity
  16. Randomized comparison of tolterodine with vaginal estrogen cream versus tolterodine alone for the treatment of postmenopausal women with overactive bladder syndrome
  17. Proof of principle: The effect of antimuscarinics on bladder filling sensations in healthy subjects—A placebo controlled double blind investigation using 4 and 8 mg tolterodine extended release
  18. Tolterodine causes measurable restoration of urethral sensation in women with urge urinary incontinence
  19. The efficacy of additive tolterodine extended release for 1-year in older men with storage symptoms and clinical benign proastatic hyperplasia
  20. Investigation of the clinical efficacy and safety of pregabalin alone or combined with tolterodine in female subjects with idiopathic overactive bladder
  21. Transdermal delivery of tolterodine by O-acylmenthol: In vitro/in vivo correlation
  22. Studies on the preparation, characterization and pharmacological evaluation of tolterodine PLGA microspheres
  23. Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine
  24. Tolterodine (TOL) prolonged release (PR) in children aged 11-15 years

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