Travocort®

Brand Bayer Pharma AG

In stock 1627 Items

Available since: 2019-09-19

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Clinical Pharmacology

Travocort® - antifungal, antibacterial, anti-inflammatory.

Pharmacodynamics

Isoconazole is a synthetic imidazole derivative. It has a broad antifungal and antibacterial spectrum of action. Fungicidal and bactericidal. Suppresses the synthesis of ergosterol cell membranes of the fungus, causing his death, blocks the synthesis of bacterial proteins. Active against dermatophytes (Trichophyton spp., Microsporum spp., Epidermophyton spp. and others), mold, yeast and yeast-like fungi (Candida spp., Pityrosporum orbiculare / ovale (Malassezia furfur), Corynebacterium minutissimum - causative agent of erythrasma and gram-positive bacteriaStaphylococcus spp., Streptococcus spp.

Diflukortolona valerat - GKS for local use. It has anti-inflammatory, antiexudative, antiallergic and antipruritic action.

Pharmacokinetics

Pharmacokinetics studies have not been conducted.

Indications

Dermatoses of combined etiology sensitive to the treatment of corticosteroids infected with fungal / bacterial flora.

Fungal lesions of the skin, incl. secondarily infected, accompanied by severe inflammatory or eczema-like symptoms:

mycoses of the feet and smooth skin, incl. with localization in the folds, interdigital spaces, the area of the external genital organs (including balanoposthitis): microsporia, trichophytosis, ruburitis, athlete's epidermis;
candidiasis;
erythrasma

Composition

100 g of cream contain:

Active substances: isoconazole nitrate 1 g, diflucortolone valerate 100 mg;

Excipients: polysorbate 60; sorbitan stearate; cetostearyl alcohol; liquid paraffin; white petrolatum; disodium edetate; purified water.

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Dosage and Administration

Topically. Travocort is applied in a thin layer on the affected skin and lightly rubbed 2 times a day (morning and night).

The maximum duration of treatment is 2 weeks.

Adverse reactions

Travocort is usually well tolerated, even when applied to sensitive skin. In rare cases, skin irritation and allergic reactions may develop. Considering that Diflucortolone is part of the Travocort preparation, when applying the cream on large surfaces (more than 10% of the skin surface) for a long time (more than 4 weeks) and / or when using an occlusive dressing, the appearance of side effects characteristic of GCS can occur: , telangiectasia, striae, acne-like dermatitis, perioral dermatitis, hypertrichosis, as well as systemic side effects (suppression of the function of the hypothalamic-pituitary-adrenal system).
It is impossible to completely exclude the development of side effects (for example, a decrease in the function of the adrenal cortex) in newborns whose mothers received long-term treatment during pregnancy or lactation or applied the drug to large body surfaces.

Carefully: II and III trimesters of pregnancy.

Pregnancy and Lactation

Like all topical preparations containing GCS, Travocort is not recommended for use during the first trimester of pregnancy.

The use of the drug in the II and III trimester of pregnancy is possible in cases where the potential benefit to the mother outweighs the possible risk to the fetus.

If necessary, the use of the drug during lactation should resolve the issue with the doctor about stopping breastfeeding.

Special instructions

Use for external use only.

Avoid contact with eyes and open wounds. In case of accidental contact with eyes, rinse thoroughly with warm water.

In patients with rosacea or perioral dermatitis, do not apply the drug to the skin of the face.

Overdosage

Phenomena of acute overdose are not described, however, with excessive or prolonged use of the drug may be a chronic overdose, accompanied by the symptoms described in the section "Side effects"

Treatment: symptomatic.