Trekrezan
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Clinical Pharmacology
Trekrezan - immunomodulatory drug with pronounced adaptogenic properties. The drug stimulates the production of α- and γ-interferons, contributes to the increase and correction of the immune status of the body due to the activation of cellular and humoral immunity, stimulates the phagocytic activity of macrophages.
The drug strengthens the body's immune system, increases endurance during physical and mental stress, reduces the effect of various toxins, increases the body's resistance to hypoxia, low and high temperatures, and other adverse environmental factors.
The drug has a pronounced anti-toxic effect in case of poisoning with ethanol, organic solvents, salts of heavy metals.
Indications
- to improve immunity (prevention and treatment of colds, flu, ARVI and other viral and bacterial diseases);
- to increase physical and mental performance and prevent overwork, increase body resistance to various stress effects (hypoxia, overheating, hypothermia);
- in secondary immunodeficiency states, including against the background of long-term antibiotic therapy;
- as part of complex therapy in case of poisoning with heavy metal salts;
- as part of the treatment of alcohol withdrawal syndrome.
Composition
- Oxyethylammonium methylphenoxyacetate (trekrezan) 200 mg
- Excipients: potato starch, milk sugar (lactose monohydrate), calcium stearic acid (calcium stearate).
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Dosage and Administration
- To improve immunity and prevent colds in adults and children over 12 years old - at 0.2 g / day for 7-14 days.
- During the treatment of a cold, flu, ORVI for adults and children over 12 years old - on the first day 0.6 g / day, then daily at a rate of 0.2 g / day for 7 days.
- To increase the physical and mental performance and enhance the body's resistance to various stressors - 0.6 g / day on the first day, then 0.2 g / day daily for 7 days.
- When poisoning with salts of heavy metals - 0.4-0.6 g / day every day for at least 5 days.
- To reduce the manifestations of alcohol withdrawal syndrome - 0.4-0.6 g / day every day for 5 days.
- If necessary, treatment is repeated at intervals of 1-2 months between courses.
Adverse reactions
In rare cases, allergic reactions.
Contraindications
- hypersensitivity to any of the components of the drug;
- children under 12 years old (due to the lack of data on the efficacy and safety of use);
- hereditary lactose intolerance;
- lactase deficiency or impaired absorption of glucose and galactose.
Drug interactions
Undesirable interactions with other drugs are not observed.
Pregnancy and Lactation
The drug is contraindicated in pregnancy and lactation.
Overdosage
Symptoms of intoxication due to overdose of drugs are not marked.
- Active ingredient: Trekrezan
- Effect of trekrezan on lipid peroxidation in patients with chronic heart failure
- Efficiency of trekrezan in experimental bronchopneumonia in rats
- Metabolic effects of trekrezan during adaptation of rats to intermittent hypoxic hypoxia
- Antisclerotic effect of Trekrezan and its possible mechanisms
- Trekrezan as a Modulator of Hemato- and Immunopoieses
- Effect of Trekrezan on Immunogenesis under Experimental Conditions
- Trekrezan as a stimulator of muscle strength and endurance. Possible molecular mechanisms of action