Buy Kenalog ampoules 40 mg/ml, 1 ml, 5 pcs
  • Buy Kenalog ampoules 40 mg/ml, 1 ml, 5 pcs

Triamcinolone

Krka dd Novo mesto AO
1641 Items
2019-09-19
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$47.85
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Clinical Pharmacology

Kenalog has anti-inflammatory, antiallergic, immunosuppressive, antipruritic action. Induces the formation of lipocortins, inhibits the release of inflammatory mediators by eosinophils, reduces the number of mast cells that produce hyaluronic acid. Kenalog reduces capillary permeability, stabilizes cell permeability, including lysosomal membranes and membranes. Slows down the release of cytokines (interleukin 1, 2, gamma interferon) from lymphocytes and macrophages. Increases gluconeogenesis, reduces tissue utilization of glucose and activates catabolic processes.

Indications

Hay fever, bronchial asthma, chronic spastic bronchitis, pemphigoid, psoriasis, dermatitis (herpetic, atopic, exfoliative, contact non-microbial etiology, eczematous). Intra-articular: chronic inflammatory diseases of the joints, exudative arthritis, gout, false gout, arthrosis, dropsy of the joints, shoulder joint blockade, chronic inflammation of the inner layer of the joint capsule; injections under the affected area: isolated psoriatic plaques, flat nodular lesions, hair loss in the form of a circle, chronic lupus erythematosus, keloids.

Composition

1 ml of suspension for injection contains triamcinolone acetonide 40 mg and benzyl alcohol 9.9 mg in isotonic sodium chloride solution.

Triamcinolone is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Kenalog Krka dd Novo mesto AO Slovenia ampoules
Kenalog pills Krka dd Novo mesto AO Slovenia pills
Triacort Akrikhin Russia ointment
Polcortolon pills Polfa Poland pills
Fluorocort Gedeon Richter Hungary ointment

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Triamcinolone

Dosage and Administration

For oral use. adults - 4-20 mg per day in 2-3 doses. After improving the state, the daily dose is gradually reduced by 1-2 mg every 2-3 days to the minimum maintenance dose of 1 mg and the full abolition of therapy.

Adverse reactions

On the part of the endocrine system: redistribution of adipose tissue, menstrual disorders, increased blood glucose levels, adrenal suppression, "moon face", striae, hirsutism, acne.

Metabolism: edema, electrolyte imbalance, negative nitrogen balance, growth retardation in children.

On the part of the digestive system: steroid gastric ulcer, erosive and ulcerative lesions of the gastrointestinal tract, acute pancreatitis.

On the part of the central nervous system: convulsions, sleep disorders, mental disorders, headaches and dizziness, weakness.

From the musculoskeletal system: myopathy, osteoporosis.

Since the cardiovascular system: arterial hypertension.

On the part of the blood coagulation system: thromboembolism.

On the part of the organ of vision: visual impairment, posterior subcapsular cataract, increased intraocular pressure or exophthalmos, anaphylactic reactions.

Reactions due to immunosuppressive effects: exacerbation of infectious diseases.

When intra-articular injection: possible joint pain, irritation at the injection site, depigmentation, sterile abscess, skin atrophy, when administered in doses of more than 40 mg, resorptive side effects are possible.

Inhalation use: possible headache, sneezing, cough, dryness of the mucous membrane of the mouth or nose, a feeling of irritation in the nose, hoarseness, rarely - fungal infection of the nasopharynx caused by Candida albicans.

When applied topically: itching, skin irritation, late reactions such as eczema, steroid acne, purpura are possible. With prolonged use of the ointment may develop secondary infectious lesions and atrophic changes in the skin.

Contraindications

Hypersensitivity, systemic mycoses, osteoporosis, glaucoma, peptic ulcer and duodenal ulcer, renal dysfunction, acute viral and bacterial infections, pregnancy, breastfeeding, children under six years of age.

Drug interactions

With simultaneous use with anabolic steroids, androgens, the risk of developing peripheral edema and acne increases.

With simultaneous use with antithyroid drugs and thyroid hormones, it is possible to change the function of the thyroid gland.

When used simultaneously with histamine H1 receptor blockers, the effect of triamcinolone is reduced; with hormonal contraceptives - potentiates the action of triamcinolone.

Hypocalcemia associated with the use of triamcinolone, can lead to an increase in the duration of the neuromuscular blockade caused by the action of depolarizing muscle relaxants with their simultaneous use.

With simultaneous use with immunosuppressants increases the risk of bacterial and viral infections.

With simultaneous use with potassium-sparing diuretics, hypokalemia is possible.

With simultaneous use may decrease the effectiveness of indirect anticoagulants, heparin, streptokinase, urokinase, increasing the risk of erosive and ulcerative lesions and bleeding from the gastrointestinal tract.

With simultaneous use with NSAIDs (including acetylsalicylic acid) increases the risk of erosive and ulcerative lesions and bleeding from the gastrointestinal tract.

With simultaneous use reduces the effect of oral hypoglycemic agents, insulin; with laxatives, hypokalemia is possible; with cardiac glycosides - increases the risk of heart rhythm disorders and other toxic effects of glycosides.

With simultaneous use with tricyclic antidepressants may increase mental disorders associated with taking triamcinolone.

At simultaneous use with m-anticholinegic (including with atropine) increase in intraocular pressure is possible.

With simultaneous use with amphotericin B, carbonic anhydrase inhibitors, there is a risk of developing hypokalemia, left ventricular myocardial hypertrophy and circulatory failure.

With simultaneous use with isoniazid, it is possible to decrease the concentration of isoniazid in the blood plasma, mainly in individuals with rapid acetylation.

With simultaneous use, acceleration of biotransformation and a decrease in plasma concentration of meksiletin are possible.

With simultaneous use with paracetamol increases the risk of hypernatremia, peripheral edema, increased calcium excretion, hypocalcemia, osteoporosis, paracetamol hepatotoxicity.

With simultaneous use with rifampicin, phenytoin, carbamazepine, barbiturates, triamcinolone metabolism is accelerated due to the induction of microsomal liver enzymes, its effect decreases.

With simultaneous use with ephedrine, triamcinolone metabolism accelerates.

Pregnancy and Lactation

Not recommended.

Special instructions

Not intended for on / in the introduction.

With caution and under strict medical supervision used for edematous syndrome, obesity, mental illness and diseases of the gastrointestinal tract. During the period of treatment, it is recommended to take vitamin D and eat foods rich in calcium.

After a single intramuscular injection in a dose of 60-100 mg for 24-48 hours, an inhibition of adrenal function can be observed, which usually recovers after 30-40 days.

When applied topically to prevent local infectious complications, it is recommended to be used in combination with antimicrobial agents.

Parenteral administration in children under the age of 6 is not recommended; at the age of 6-12 years - according to strict indications.

Avoid prolonged external use in children, regardless of age.

  • Brand name: Kenalog
  • Active ingredient: Triamcinolone
  • Dosage form: Suspension for injection.
  • Manufacturer: Krka dd Novo mesto AO
  • Country of Origin: Slovenia

Studies and clinical trials of Triamcinolone (Click to expand)

  1. Effect of triamcinolone acetonide on the development of the pulmonary airways in the fetal rat
  2. New News about an Old Drug: Investigations on the Polymorphism of Triamcinolone Acetonide
  3. Synthesis of N-benzyl-O-carboxymethylchitosan and application in the solubilization enhancement of a poorly water-soluble drug (triamcinolone)
  4. Drug-Protein Conjugates: Preparation of Triamcinolone-Acetonide Containing Bovine Serum Albumin/Keyhole Limpet Hemocyanin-Conjugates and Polyclonal Antibodies
  5. Use of triamcinolone hexacetonide for the treatment of osteoarthritis of the hip: Comment on the letter by Margules
  6. Further experiences with Δ1, 9 alpha fluoro, 16 alpha hydroxyhydrocortisone (triamcinolone) in treatment of patients with rheumatoid arthritis
  7. Treatment of rheumatoid joint inflammation with triamcinolone hexacetonide
  8. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage
  9. Intraarticular triamcinolone hexacetonide in the management of chronic arthritis in children
  10. Radiographic followup of joints injected with triamcinolone hexacetonide for the management of childhood arthritis
  11. Immediate “steroid flare” from intraarticular triamcinolone hexacetonide injection: Case report and review of the literature
  12. Relative ineffectiveness of triamcinolone acetonide in the treatment of juvenile idiopathic arthritis
  13. Effect of injection of triamcinolone on type 1 procollagen and fibronectin in scar tissue
  14. Triamcinolone up-regulates GLUT 1 and GLUT 3 expression in cultured human placental endothelial cells
  15. Metastasis and the reticuloendothelial system. II. Effect of triamcinolone acetonide on organ retention of malignant cells in endotoxin-treated mice
  16. Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems
  17. Analysis of dexamethasone, triamcinolone, and their metabolites in human urine by microcolumn liquid and capillary gas chromatography mass spectrometry
  18. Synthesis of triamcinolone acetonide-4-14C
  19. Determination of triamcinolone in human plasma by a sensitive HPLC–ESI-MS/MS method: application for a pharmacokinetic study using nasal spray formulation
  20. Comparison of skin stripping, in vitro release, and skin blanching response methods to measure dose response and similarity of triamcinolone acetonide cream strengths from two manufactured sources
  21. Microdialysis of triamcinolone acetonide in rat muscle
  22. Steroid borates III. Use in preparation of triamcinolone 21-hemisuccinate and other 21-monoesters
  23. Stabilization of tetrazolium blue assay for triamcinolone
  24. Solubility and dissolution of triamcinolone acetonide

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