Triazavirin®
Medical synthesis
35 Items
2019-09-19
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Clinical Pharmacology
Pharmacodynamics:
The active ingredient of the drug Triazavirin® is a synthetic analogue of the bases of purine nucleosides (guanine) with a pronounced antiviral effect. It has a wide spectrum of antiviral activity against RNA-containing viruses.
The main mechanism of action of the drug Triazavirin® is the inhibition of the synthesis of viral RNA and the replication of genomic fragments.
Pharmacokinetics:
After ingestion is rapidly absorbed in the gastrointestinal tract. Maximum concentration (Cthatx) is achieved on average in 1-1.5 hours. Cmaxat) the recommended dosing regimen averages 4.8 mcg / ml. The blood AUC (area under the pharmacokinetic curve "concentration - time") of blood is 12.8 mcg / h * ml. Elimination half-life (ti/2) - 1-1.5 hours
From 15 to 45% of the drug is excreted by the kidneys in unchanged form. The average calculated clearance is 246 ml / min.
Indications
Treatment of influenza in adults. If necessary, combined with the reception of symptomatic agents.
Composition
Active substance:
Methylthionitrooxodihydro-triazolotriazinide sodium dihydrate (triazavirin) - 250 mg.
Excipients:
Calcium stearate - 2 mg;
The mass of the contents of the capsule - 252 mg;
The composition of the shell of capsules:
Capsule (case) No. 1: titanium dioxide (E171), yellow quinoline (E104), yellow “sunset” (E110), medical gelatin.
Capsule (cap) No. 1: titanium dioxide (E171), azorubine (E122), medical gelatin.
The mass of the capsule with the contents - 328 mg
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Dosage and Administration
Triazavirin® is applied inside regardless of the meal.
Therapeutic doses
The drug should be started no later than the 2nd day from the onset of the disease (onset of clinical symptoms) 1 capsule (250 mg) 3 times a day (daily dose 750 mg) for 5 days. If necessary, treatment can be continued up to 7 days.
Adverse reactions
allergic reactions;
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part of the digestive system: dyspeptic disorders (flatulence, diarrhea, nausea, vomiting).
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.
Contraindications
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hypersensitivity to the drug;
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pregnancy;
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breastfeeding period;
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children's age up to 18 years (efficiency and safety are not defined);
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renal / hepatic impairment (efficacy and safety not determined).
Drug interactions
Interaction with analogues of purine and pyrimidine bases during antitumor therapy may lead to increased drug toxicity. With simultaneous use with ribavirin, ribavirin dose reduction is required.
Pregnancy and Lactation
The use of the drug during pregnancy has not been studied.
The use of the drug during lactation has not been studied, therefore, if necessary, use of the drug during lactation should stop breastfeeding.
Overdosage
Symptoms: nausea, vomiting, dyspeptic disorders, stomach pain.
Treatment: symptomatic therapy. When these symptoms appear, you must stop taking the drug.
- Brand name: TRIAZAVIRIN
- Active ingredient: Methylthionitroxodihydro-triazolotriazinide sodium
- Dosage form: Capsules
- Manufacturer: Medical synthesis
- Country of Origin: Russia
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