Triderm®

Ointment Triderm should be applied with a thin layer to the entire affected skin surface and surrounding tissue twice a day - in the morning and at night. To ensure the effectiveness of treatment Triderm ointment must be applied regularly. The duration of therapy depends on the size and location of the lesion, as well as the response of the patient. If clinical improvement does not occur after 3-4 weeks of baking, this may be a reason to clarify the diagnosis.

The use of Triderm during pregnancy is possible only in the case when the intended benefits to the mother outweigh the potential risk to the fetus. It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing a Triderm during lactation, it is necessary to decide on the termination of breastfeeding.

Do not use in ophthalmic practice. Prolonged local use of antibiotics can sometimes lead to the growth of resistant microflora. In this case, as well as with the development of irritation, sensitization or superinfection during the background of the use of Triderm, treatment should be interrupted and appropriate therapy should be prescribed. Allergic cross-reactions with aminoglycoside antibiotics have been observed. Any side effects that occur with the use of systemic glucocorticosteroids, including inhibition of the function of the adrenal cortex, can also be observed with topical administration of glucocorticosteroids, especially in children. Systemic absorption of glucocorticosteroids or gentamicin when applied topically will be higher if treatment is carried out on large surfaces of the body or when using occlusive dressings. Gentamicin should not be applied to open wounds or damage to the skin. Appropriate precautions should be taken in such cases, especially when treating children. The abolition of the drug after prolonged use is recommended to be carried out gradually.
Use in pediatrics: children are prescribed from the age of 2 only according to strict indications and under medical supervision, since possible development of systemic side effects associated with betamethasone. When using Triderm, as well as many other topical glucocorticosteroids on large surfaces and / or with an occlusive bandage, the function of the hypothalamic-pituitary-adrenal system may be suppressed, a decrease in growth hormone excretion and an increase in intracranial pressure may be observed.

Symptoms: With prolonged use of local corticosteroids in high doses, it is possible to suppress adrenal function with the development of secondary adrenal insufficiency and symptoms of hypercorticism, including Cushing syndrome. An overdose of clotrimazole with its local application does not lead to the appearance of any symptoms. With a single overdose of gentamicin, no symptoms are expected either. Long-term treatment with gentamicin in high doses can lead to an increase in insensitive flora.
Treatment: symptomatic. The acute symptoms of hypercortisolism are usually reversible. If necessary, carry out the correction of electrolyte imbalance.In the case of chronic GCS toxicity, the gradual abolition of GCS is recommended.