Trombovasim
1698 Items
2019-09-19
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Clinical Pharmacology
Fibrinolytic agent. It has thrombolytic, anti-inflammatory and cardioprotective effects.
The mechanism of thrombolytic action is associated with the direct destruction of the fibrin filaments that form the main framework of the thrombus. The mechanism of anti-inflammatory action is associated with the effect on the oxidative function of blood neutrophils and tissue macrophages. The mechanism of cardioprotective action is associated with improved blood supply to the myocardium.
Trombovasim® is a low toxic drug.
Trombovasim® does not reduce the level of platelets and does not affect the clotting time and duration of bleeding.
Indications
As an aid in the complex treatment of chronic venous insufficiency.
Composition
1 caps - a complex of proteinases produced by Bacillus subtilis, immobilized by radiation on macrogol 1500 with the addition of dextran (Thrombovazim) 400 units.
Excipients: potato starch - 261 mg, microcrystalline cellulose - 120 mg, sodium chloride - 9 mg.
The composition of the gelatin capsule: dyes - azoruby (E122), patent blue V (E131), titanium dioxide (E171); gelatin.
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Dosage and Administration
It is taken orally 30-40 minutes before meals at a dose of 800-1600 IU per day in 2 divided doses. The maximum daily dose is 2000 units. The course of treatment is 20 days. In the absence of effectiveness during the course of treatment, the patient should consult a doctor. If necessary, it is possible to conduct repeated courses on the recommendation of a doctor.
Adverse reactions
From the digestive system: rarely - dyspeptic symptoms (nausea, vomiting, feeling of heaviness in the stomach).Others: possibly - allergic reactions, a temporary feeling of fullness in the lower extremities.
Drug interactions
Heparin, dipyridamole, acetylsalicylic acid enhances the antithrombotic effect without increasing the risk of bleeding.The use of tetracycline antibiotics (tetracycline, chlortetracycline hydrochloride and oxytetracycline hydrochloride) enhances the effect of fibrinolytics.
If it is necessary to use preparations containing salts of bivalent metals (calcium, magnesium, zinc, iron) due to a possible decrease in enzyme activity, it is advisable to observe the interval between taking Trombovazim® and these preparations for at least 40 minutes.
- Brand name: Trombovasim
- Active ingredient: Trombovasim
- Dosage form: Hard gelatin capsules, No. 0, with a white casing and a lid of dark pink, with a white overprint "Trombovasim, capsule contents - powder from white with a yellowish-brown shade to light brown.
- Manufacturer: G.L.Farma GmbH
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