Troxerutin
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Clinical Pharmacology
Troxerutin - venotonic, angioprotective agent, bioflavonoid. Reduces the permeability and fragility of capillaries, strengthens the vascular wall, improves microcirculation, has anti-edema effect. Participates in redox processes, blocks cell hyaluronic acid. Increases the density of the vascular wall, reduces the exudation of the liquid part of the plasma and diapedes blood cells. Reduces inflammation in the vascular wall, limiting adhesion to its surface platelets.
The use of Troxerutin is possible both in the initial and in the late stages of the treatment of chronic venous insufficiency, it can be used as one of the components of the complex treatment.
Indications
Phlebeurysm; chronic venous insufficiency with such manifestations as edema, pain, heaviness in the lower limbs; surface thrombophlebitis, peripheral, phlebothrombosis; postthrombotic syndrome; post-traumatic edema, hematomas; prevention of complications after vein surgery; hemorrhoids.
Composition
100 g of gel contains the active substance: troxerutin - 2.0 g
Troxerutin is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Troxerutin | Sopharma | Bulgaria | gel |
Troxerutin | Biochemist Saransk | Russia | gel |
Troxerutin | Ozon | Russia | gel |
Troxerutin | Ozon | Russia | capsules |
Troxerutin | Zentiva KS | Czech | capsules |
Troxevasin Neo | Balkanpharma | Bulgaria | gel |
Troxevasin | Balkanpharma | Bulgaria | capsules |
Troxerutin | VetProm AD | Bulgaria | gel |
Troxerutin | Sopharma | Bulgaria | capsules |
Troxerutin-MIC | Minskintercaps | Belarus | capsules |
Troxerutin | Vramed | Bulgaria | gel |
Troxevasin | Balkanpharma | Bulgaria | gel |
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Dosage and Administration
Externally: the gel is applied evenly in a thin layer in the morning and evening on the skin over the painful area and lightly massaged until completely absorbed. The dose of the drug depends on the area of the damaged surface, but should not exceed 3-4 cm of gel (1.5-2 g). The gel can be applied under the occlusive dressing.
Adverse reactions
In some cases, possible allergic reactions (skin rash).
With care: a renal failure (long use).
- Brand name: Troxerutin
- Active ingredient: Troxerutin
- Dosage form: Gel for external use
- Manufacturer: Sopharma
Studies and clinical trials of Troxerutin (Click to expand)
- Evaluation of the safety of a coumarin–troxerutin combination
- Spectroscopic studies on the interaction between troxerutin and bovine serum albumin
- Regioselective enzymatic acylation of troxerutin in nonaqueous medium
- The electrochemical oxidation of troxerutin and its sensitive determination in pharmaceutical dosage forms at PVP modified carbon paste electrode
- The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet–visible detection
- Ultrasound-promoted enzymatic synthesis of troxerutin esters in nonaqueous solvents
- Liquid chromatography/tandem mass spectrometry assay for the quantification of troxerutin in human plasma
- Prospektive, doppelblinde Therapiestudie zur Prophylaxe der Radioxerostomie durch Cumarin/Troxerutin bei Patienten mit Kopf-Hals-Karzinomen
- LC–MS–MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study
- Protection of cellular DNA from γ-radiation-induced damages and enhancement in DNA repair by troxerutin
- Treatment of the common cold with troxerutin
- NGF-Dependent Activation of TrkA Pathway: A Mechanism for the Neuroprotective Effect of Troxerutin in D-Galactose-Treated Mice
- One-electron redox reactions of troxerutin in aqueous solutions
- Troxerutin protects the isolated perfused rat liver from a possible lipid peroxidation by coumarin
- Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances
- Chronic administration of troxerutin protects mouse kidney against d-galactose-induced oxidative DNA damage
- Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation
- Chronic administration of troxerutin protects mouse brain against d-galactose-induced impairment of cholinergic system
- Troxerutin-carbazochrome combination versus placebo in the treatment of posthemorrhoidectomy symptoms: a single-center, randomized, double-blind, placebo-controlled study
- Homocysteine content of plasma in ischemic heart disease, the reducing effect of pyridoxine, folate, cobalamin, choline, riboflavin and troxerutin. Correction of a calculation error
- Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats
- Erratum to: Protective Effects of Troxerutin on β-Amyloid (1-42)-Induced Impairments of Spatial Learning and Memory in Rats
- Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin, and troxerutin in atherosclerosis